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1.发明授权
公开(公告)号：KR101099786B1
公开(公告)日：2011-12-28
申请号：KR1020090058304
申请日：2009-06-29
Applicant: 한국인스팜(주)
Abstract: 본 발명은 뇌세포 보호 활성을 갖는 조성물에 관한 것으로, 상세하게는 원지 조 추출물의 산가수분해성 분획물을 유효성분으로 함유하는 본 발명의 조성물은 뇌세포에 대한 뛰어난 보호 및 항산화 효과를 나타내므로, 퇴행성 뇌질환의 예방 및 치료를 위한 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
원지, 뇌 세포 보호, 산가수분해물, 항산화효과-
公开(公告)号：KR1020110000951A
公开(公告)日：2011-01-06
申请号：KR1020090058304
申请日：2009-06-29
Applicant: 한국인스팜(주)
CPC classification number: A61K36/69 , A23V2200/322 , A61K2236/331 , A61K2236/333
Abstract: PURPOSE: A composition with an activity of protecting brain cells is provided to ensure antioxidative activity and to prevent and treat neurodegenerative brain cells. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative brain diseases contains acid hydrolytic fraction of Polygalae Radix crude extract as an active ingredient. The crude extract is isolated using water, methanol, ethanol, butanol or mixture solvent thereof. A method for preparing the acid hydrolytic fraction comprises: a step of extracting dried Polygalae Radix with polar solvent by heating, ultrasonic extraction, reflux extraction to obtain Polygalae Radix crude extract; a step of adding hydrochloric acid, nitric acid, diluted sulfuric acid or acetic acid; a step of heating at 50-100°C for 12-48 hours; a step of adding sodium hydroxide, potassium hydroxide, potassium carbonate and sodium hydrogen carbonate; and a step of fractioning the acid hydrolysate solution with ether, chloroform, ethyl acetate and acetone by solvent-solvent distribution.
Abstract translation: 目的：提供具有保护脑细胞活性的组合物，以确保抗氧化活性，并预防和治疗神经退行性脑细胞。 构成：用于预防和治疗神经退行性脑疾病的药物组合物含有Polygalae Radix粗提物的酸水解部分作为活性成分。 粗提物用水，甲醇，乙醇，丁醇或其混合溶剂分离。 一种制备酸性水解馏分的方法，包括：通过加热，超声提取，回流提取，用极性溶剂萃取干燥的Polygalae Radix获得Polygalae Radix粗提物的步骤; 加入盐酸，硝酸，稀硫酸或乙酸的步骤; 在50-100℃下加热12-48小时的步骤; 加入氢氧化钠，氢氧化钾，碳酸钾和碳酸氢钠的步骤; 并通过溶剂 - 溶剂分配用乙醚，氯仿，乙酸乙酯和丙酮分级酸水解产物溶液的步骤。
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