公开(公告)号：KR1020040051282A

公开(公告)日：2004-06-18

申请号：KR1020020079182

申请日：2002-12-12

Applicant: 한국전자통신연구원

Inventor： 정명애 ,  전길자 ,  이윤실

IPC: B82B3/00 ,  B82Y5/00 ,  B82Y40/00 ,  A61K9/51

CPC classification number: A61K9/51 ,  A61K31/047 ,  A61K31/16 ,  B82Y5/00 ,  B82Y40/00

Abstract: PURPOSE: Smart nanoparticles containing oleamide or monoacetyl diglyceride(MADG), medicinal components, in the core of the micelle composed of poly(N-vinyl caprolactam) are provided to show good selectivity for diseased organs, and decrease ill effects on the normal cells and the dosage needed. CONSTITUTION: The smart nanoparticles(50), being 50-300nm in size, are prepared by the following steps of: (i) mixing medicinal materials, N-vinyl caprolactam monomer and surfactant for emulsifying, wherein the medical materials are oleamide extracted from ganoderma lucidum karst and monoacetyl diglyceride extracted from deer antlers, and the surfactant is an anion surfactant such as sodium dodecyl sulfate(SDS) or cationic surfactant such as cetyltrimethyl ammonium bromide(CTAB) and the amount of surfactant is between the first critical micelle concentration(CMC) and the second critical micelle concentration; (ii) polymerizing the emulsified caprolactam monomer at 40-90deg.C with stirring in a rate of 500-2000rpm to control the size of nanoparticles, wherein 0.1-1wt.% of polymerizing initiator(based on the total amount of N-vinyl caprolactam monomer) such as potassium persulfate or ammonium persulfate is used. The medicinal material such as MADG or oleamide is encapsulated in a core(52) of nanoparticles and the core is encapsulated in a micelle(54) comprising N-vinyl caprolactam monomer.

Abstract translation: 目的：提供含有油酰胺或单乙酰己二酸甘油酯（MADG）的智能纳米颗粒，其是由聚（N-乙烯基己内酰胺）构成的胶束芯中的药物组分，以显示对患病器官的良好选择性，并减少对正常细胞的不良影响， 所需剂量。 构成：尺寸为50-300nm的智能纳米颗粒（50）通过以下步骤制备：（i）将医药材料，N-乙烯基己内酰胺单体和用于乳化的表面活性剂混合，其中医用材料是从灵芝中提取的油酰胺 灵芝岩溶和从鹿角鹿提取的单乙酰甘油二酯，表面活性剂是十二烷基硫酸钠（SDS）或阳离子表面活性剂如十六烷基三甲基溴化铵（CTAB）等阴离子表面活性剂，表面活性剂的量介于第一临界胶束浓度 ）和第二临界胶束浓度; （ii）在搅拌下以500-2000rpm的速度在40-90℃下聚合乳化的己内酰胺单体以控制纳米颗粒的尺寸，其中0.1-1重量％的聚合引发剂（基于N-乙烯基己内酰胺的总量 单体）如过硫酸钾或过硫酸铵。 将药物材料如MADG或油酰胺包封在纳米颗粒的核心（52）中，并将核心包封在包含N-乙烯基己内酰胺单体的胶束（54）中。

公开(公告)号：KR100554162B1

公开(公告)日：2006-02-22

申请号：KR1020020079182

申请日：2002-12-12

Applicant: 한국전자통신연구원

Inventor： 정명애 ,  전길자 ,  이윤실

IPC: B82B3/00 ,  B82Y5/00 ,  B82Y40/00 ,  A61K9/51

Abstract: 유화 중합에 의해 얻어진 폴리(N-비닐 카프로락탐)으로 이루어지는 미셀의 코어에 올레아미드(oleamide) 또는 모노아세틸디글리세라이드(MADG)와 같은 치료 약물이 포획된 스마트 나노 입자 및 그 제조 방법에 관하여 개시한다. 본 발명에 따른 스마트 나노 입자를 제조하기 위하여, 치료 약물과 N-비닐 카프로락탐 단량체를 계면활성제와 함께 교반하여 유화시킨다. 상기 유화된 N-비닐 카프로락탐 단량체를 중합시켜, 상기 치료 약물이 균일하게 함유된 코아를 가지는 미셀로 이루어지는 나노 입자를 형성한다.
비닐 카프로락탐, 올레아미드, MADG, 스마트 나노 입자