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公开(公告)号：WO2013176454A1
公开(公告)日：2013-11-28
申请号：PCT/KR2013/004429
申请日：2013-05-21
Applicant: 한국콜마주식회사
CPC classification number: B01D15/325 , G01N30/34 , G01N33/82
Abstract: 본 발명은 액체 크로마토그래피를 이용한 2종 이상의 비타민을 동시에 분석하는 방법으로서, (A) 2종 이상의 비타민을 포함하는 시료 용액을 준비하는 단계; (B) 고정상으로서 비극성 컬럼을 갖는 액체 크로마토그래피의 컬럼에 상기 시료 용액을 주입하는 단계; 및 (C) 이동상으로서 유기용액 및 수용액을 흘려주는 단계를 거쳐 다양한 종류의 비타민 성분들을 신속하게 분리할 수 있으며, 분리도가 높아 다수의 비타민 성분을 포함하는 시료 분석에 유용하다.
Abstract translation: 本发明涉及使用液相色谱法同时分析两种或更多种类型的维生素的方法。 该方法包括：（A）制备含有两种或更多种类型的维生素的样品溶液的步骤; （B）将样品溶液注入具有固定相非极性柱的液相色谱柱的步骤; 和（C）应用流动相有机溶液和水溶液的步骤。 因此，本发明的方法可以快速分离各种维生素成分，并且可以表现出优异的分离性能，因此可以有价值地用于分析含有多种维生素成分的样品。
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公开(公告)号：WO2014038895A1
公开(公告)日：2014-03-13
申请号：PCT/KR2013/008090
申请日：2013-09-06
Applicant: 한국콜마주식회사
CPC classification number: A61K31/41 , A61K9/2027 , A61K9/2866
Abstract: 본 발명은 발사르탄을 함유하는 고형 경구제형의 제조방법 및 고형 경구제형에 관한 것으로, 보다 상세하게는 습식 과립법에 의해 제조되는 발사르탄 또는 그 염을 포함하는 고형 경구제형의 제조방법 및 그에 의해 제조되는 고형 경구제형에 관한 것이다. 본 발명의 발사르탄 함유 고형 경구제형의 제조방법은 발사르탄을 함유하는 고형 경구제형을 습식과립법으로 제조하는 것을 가능하게 한다. 상기 제조방법으로 제조된 발사르탄 함유 고형 경구제형은 뛰어난 발사르탄의 분산성, 생체 이용률 및 용출률을 제공한다.
Abstract translation: 本发明涉及一种制备含缬沙坦和固体口服剂型的固体口服剂型的方法，更具体地涉及制备含有通过湿法制粒制备的缬沙坦或其盐的固体口服剂型的方法，以及 由此制备固体口服剂型。 含有本发明缬沙坦的固体口服剂型的制备方法能够通过湿法制粒制备含有缬沙坦的固体口服剂型。 通过制备方法制备的含缬沙坦的固体口服剂型提供了显着的缬沙坦分散，生物利用度和溶解速率。
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公开(公告)号：WO2014208901A1
公开(公告)日：2014-12-31
申请号：PCT/KR2014/004895
申请日：2014-06-02
CPC classification number: A61K9/107 , A61K9/0048 , A61K9/0051
Abstract: 본 발명은 물에 대하여 난용성인 의약품에 대한 수중유적형 에멀젼 조성물 및 이의 제조방법에 관한 것이다. 구체적으로, 난용성 의약품의 가용성을 향상시키기 위하여, 소수성 부분이 두 개 이상의 사슬구조를 가진 계면활성제를 (A) 난용성 의약품에 대비하여 (B) 계면활성제의 중량비가 1: 0.5~100이 되도록 포함하는 국소투여용 또는 주사용 수중유적형 에멀젼 조성물 및 이의 제조방법에 관한 것이다.
Abstract translation: 本发明涉及难溶于水的药物的水包油型乳剂组合物及其制备方法。 特别地，本发明涉及一种用于局部给药或注射的水包油型乳剂组合物，其包含为了提高难溶性药物的溶解性，其中疏水部分具有两个或更多个的表面活性剂 链状结构，即（A）水难溶性药物，（B）表面活性剂的重量比为1:0.5〜100，以及其制备方法。
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公开(公告)号：KR1020140043577A
公开(公告)日：2014-04-10
申请号：KR1020120106091
申请日：2012-09-24
Applicant: 한국콜마주식회사
IPC: A61K9/08 , A61K9/107 , C07D311/36 , A61K31/352
CPC classification number: A61K47/50 , A61K9/0095 , A61K31/352 , A61K47/12 , A61K2121/00
Abstract: The present invention relates to a water-insoluble isoflavone covered with amorphous surfactant and a method for preparing the same. The water-insoluble isoflavone covered with amorphous surfactant according to an embodiment of the present invention comprises 100 parts by weight of isoflavone and 10-200 parts by weight of surfactants having two or more alkyl chains bonded to hydrophilic parts based on the isoflavone. The surfactant is bonded as amorphously surrounding the outside of the isoflavone and is dissolved in water in an emulsion type. The isoflavone to which the surfactant is bonded has 0.5 to 30 micrometers of average diameter, and ±200% average range of size based on the diameter. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble material; (CC) Surfactant; (DD) Alkyl chain part of the surfactant
Abstract translation: 本发明涉及覆盖有无定形表面活性剂的水不溶性异黄酮及其制备方法。 根据本发明实施方案的用无定形表面活性剂覆盖的水不溶性异黄酮包含100重量份的异黄酮和10-200重量份的具有两个或多个基于异黄酮的亲水部分键合的烷基链的表面活性剂。 表面活性剂非晶态地结合在异黄酮的外部，并溶解在乳液型的水中。 表面活性剂结合的异黄酮的平均直径为0.5〜30微米，基于直径的平均尺寸范围为±200％。 （AA）表面活性剂的亲水部分（AA） （BB）微溶材料; （CC）表面活性剂; （DD）表面活性剂的烷基链部分
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公开(公告)号：KR1020140043575A
公开(公告)日：2014-04-10
申请号：KR1020120106089
申请日：2012-09-24
Applicant: 한국콜마주식회사
IPC: A61K9/08 , A61K9/107 , C07D405/04 , A61K31/506
CPC classification number: A61K47/50 , A61K9/0095 , A61K31/7068 , A61K47/12 , A61K2121/00
Abstract: The present invention relates to a water-insoluble capecitabine covered with amorphous surfactant and a method for preparing the same. The water-insoluble capecitabine covered with amorphous surfactant according to an embodiment of the present invention comprises 100 parts by weight of capecitabine and 10-200 parts by weight of surfactants having two or more alkyl chains bonded to hydrophilic parts based on the capecitabine. The surfactant is bonded as amorphously surrounding the outside of the capecitabine and is dissolved in water in an emulsion type. The capecitabine to which the surfactant is bonded has 0.5 to 30 μm of average diameter, and ±200% average range of size. [Reference numerals] (AA) Unit blade forming a mixed blade structure body; (BB) Each blade of the unit blades forming the mixed blade structure body
Abstract translation: 本发明涉及覆盖有无定形表面活性剂的水不溶性卡培他滨及其制备方法。 根据本发明实施方案的用无定形表面活性剂覆盖的水不溶性卡培他滨包含100重量份的卡培他滨和10-200重量份的基于卡培他滨与亲水部分键合的两个或多个烷基链的表面活性剂。 表面活性剂以无定形的方式结合在卡培他滨的外部，并以乳液型溶解在水中。 结合表面活性剂的卡培他滨的平均直径为0.5〜30μm，平均尺寸范围为±200％。 （附图标记）（AA）形成混合叶片结构体的单位叶片; （BB）单元叶片的每个叶片形成混合叶片结构体
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Patent Agency Ranking
公开(公告)号：KR1020140043572A
公开(公告)日：2014-04-10
申请号：KR1020120106086
申请日：2012-09-24
Applicant: 한국콜마주식회사
IPC: A61K9/08 , A61K9/107 , C07D403/14 , A61K31/496
CPC classification number: A61K47/50 , A61K9/0095 , A61K31/496 , A61K47/12 , A61K2121/00
Abstract: The present invention relates to an amorphous itraconazole covered with a surfactant and a preparation method thereof. The amorphous itraconazole covered with a surfactant according to an embodiment in the present invention comprises: 100 parts by weight of itraconazole; and 10-200 parts by weight of a surfactant with respect to the weight of the itraconazole, wherein the surfactant has two or more alkyl chains adhering to a hydrophilic part thereof. The surfactant adheres to the itraconazole while surrounding the outside of the itraconazole in an amorphous form, so that the itraconazole is dissolved in an emulsion type in water. The itraconazole to which the surfactant adheres has an average diameter of 0.5-30 micrometers, and the average size range of the itraconazole is within ±200% with respect to the diameter of the itraconazole. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble substance; (CC) Surfactant; (DD) Alkyl chain part of the surfactant
Abstract translation: 本发明涉及用表面活性剂覆盖的非晶伊曲康唑及其制备方法。 根据本发明实施方案的用表面活性剂覆盖的无定形伊曲康唑包含：100重量份伊曲康唑; 相对于伊曲康唑的重量为10〜200重量份的表面活性剂，其中表面活性剂具有两个或更多个附着于其亲水部分的烷基链。 表面活性剂粘附在伊曲康唑上，同时围绕伊曲康唑外部呈无定形状态，使得伊曲康唑以乳液型溶于水中。 表面活性剂粘附的伊曲康唑的平均直径为0.5-30微米，伊曲康唑的平均尺寸范围相对于伊曲康唑的直径在±200％以内。 （AA）表面活性剂的亲水部分（AA） （BB）微溶性物质; （CC）表面活性剂; （DD）表面活性剂的烷基链部分
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公开(公告)号：KR1020140043562A
公开(公告)日：2014-04-10
申请号：KR1020120105992
申请日：2012-09-24
Applicant: 한국콜마주식회사
IPC: A61K9/08 , A61K9/107 , A61K31/5575 , A61P27/06
CPC classification number: A61K47/50 , A61K9/0095 , A61K31/5575 , A61K47/12 , A61K2121/00
Abstract: The present invention relates to an amorphous latanoprost covered with a surfactant and a preparation method thereof. The amorphous latanoprost covered with a surfactant according to an embodiment in the present invention comprises: 100 parts by weight of latanoprost; and 10-200 parts by weight of a surfactant with respect to the weight of the latanoprost, wherein the surfactant has two or more alkyl chains adhering to a hydrophilic part thereof. The surfactant adheres to the latanoprost while surrounding the outside of the latanoprost in an amorphous form, so that the latanoprost is dissolved in an emulsion type in water. The latanoprost to which the surfactant adheres has an average diameter of 0.5-30 micrometers, and the average range size of the latanoprost is ±200% with respect to the diameter of the latanoprost. [Reference numerals] (AA) Units blades constituting a mixed blade structure; (BB) Each blade of the units blades constituting a mixed blade structure
Abstract translation: 本发明涉及用表面活性剂覆盖的无定形拉坦前列素及其制备方法。 根据本发明实施方案的用表面活性剂覆盖的无定形拉坦前列素包括：100重量份的拉坦前列素; 相对于拉坦前列素的重量为10〜200重量份的表面活性剂，其中表面活性剂具有两个或更多个附着于其亲水部分的烷基链。 表面活性剂粘附到拉坦前列素，同时以非晶形式围绕拉坦前列素的外部，使得拉坦前列素溶解在水中的乳液型中。 表面活性剂粘附的拉坦前列素平均直径为0.5-30微米，拉坦前列素的平均范围大小相对于拉坦前列素的直径为±200％。 （附图标记）（AA）构成混合叶片结构的叶片单位; （BB）构成混合叶片结构的单元叶片的每个叶片
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公开(公告)号：KR1020150030971A
公开(公告)日：2015-03-23
申请号：KR1020130110362
申请日：2013-09-13
CPC classification number: A61K47/24 , A61K9/107 , A61K31/37 , A61K31/5575 , A61K31/573 , A61K38/08 , A61K47/10 , A61K47/12 , A61K47/34 , A61K2121/00
Abstract: 본 발명은 난용성 의약품의 수용액상 에멀젼 조성물 및 이의 제조방법에 관한 것이다. 본 발명의 난용성 의약품의 수용액상 에멀젼 조성물은 종래의 리포좀 형태 또는 유화형태로 난용성 의약품을 가용화한 방법에 비하여 독성을 띄거나 부작용이 있는 가용화제 등을 사용할 필요 없이 안정하게 난용성 의약품을 분산시킬 수 있고, 현저하게 많은 양의 난용성 의약품을 분산 시킬 수 있는 장점이 있다.
Abstract translation: 本发明涉及水溶液中的水不溶性药物产品的乳液组合物，与现有的方法相比，可以以稳定的方式显着分散大量的水溶性药物，而不使用增溶剂 将不溶于水的药物产品溶解在脂质体或乳液形式中，其中现有方法中的增溶剂具有毒性或副作用，及其制造方法。
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公开(公告)号：KR1020140043256A
公开(公告)日：2014-04-09
申请号：KR1020120105996
申请日：2012-09-24
Applicant: 한국콜마주식회사
CPC classification number: A61K31/202 , A61K9/127 , A61K47/24
Abstract: The present invention relates to a water-insoluble omega-3 and a method for manufacturing the same. The water-insoluble omega-3 according to an embodiment of the present invention includes 100 parts by weight of an omega-3 and 10 to 200 parts by weight of a surfactant having two or more alkyl chains attached to a hydrophilic portion of the omega-3. The surfactant is bonded by amorphously surrounding an outer side of the omega-3 and is dissolved in water in an emulsion type, wherein an average diameter of the omega-3 to which the surfactant is attached is 0.5-30 micrometers and an average size range is within ±200% of a standard diameter. [Reference numerals] (AA) Unit blade forming a mixed blade structure; (BB) Each blade of the unit blades forming the mixed blade structure
Abstract translation: 本发明涉及一种水不溶性ω-3及其制造方法。 根据本发明实施方案的水不溶性ω-3包括100重量份的ω-3和10至200重量份的表面活性剂，其具有两个或多个连接到ω- 3。 表面活性剂通过无定形地围绕ω-3的外侧而结合，并且以乳液型溶解在水中，其中附着有表面活性剂的ω-3的平均直径为0.5-30微米，平均尺寸范围 在标准直径的±200％以内。 （附图标记）（AA）形成混合叶片结构的单元叶片; （BB）单元叶片的每个叶片形成混合的叶片结构
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公开(公告)号：KR1020130105538A
公开(公告)日：2013-09-25
申请号：KR1020130028081
申请日：2013-03-15
Abstract: PURPOSE: A solid matter for water-insoluble material covered amorphous surfactant is provided to dissolve insoluble material and to have extremely high size homogeneity of insoluble materials with surfactant attached. CONSTITUTION: A solid matter for water-insoluble material covered amorphous surfactant includes an insoluble material (100) insoluble to water; and a surfactant (200) which has two or more alkyl chains (202) attached to a hydrophilic part (201). The amount of the surfactant is 10-200 wt% of the insoluble material. The surfactant surrounds the outer part of the insoluble material in an amorphous shape, is attached to the same, and is dissolved in water in an emulsion type. The average particle diameter of the insoluble material with the surfactant attached is 0.5-30 um, and the average range thereof is ±200% based on the diameter.
Abstract translation: 目的：提供用于溶解不溶性材料的水不溶性材料的固体物质，并使表面活性剂附着的不溶物质具有非常高的尺寸均匀性。 构成：用于水不溶性材料的无定形表面活性剂的固体物质包括不溶于水的不溶物质（100）; 和具有两个或多个连接到亲水部分（201）上的烷基链（202）的表面活性剂（200）。 表面活性剂的量为不溶物质的10〜200重量％。 表面活性剂以不定形形式包围不溶物质的外部部分，与其相连，并以乳液型溶于水中。 表面活性剂附着的不溶物的平均粒径为0.5-30μm，平均粒径为直径±200％。
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