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1.发明公开
公开(公告)号：KR1020110048337A
公开(公告)日：2011-05-11
申请号：KR1020090105097
申请日：2009-11-02
Applicant: 한국화학연구원
IPC: C07C239/14 , C07C231/14 , A61K31/165 , A61P35/00
Abstract: PURPOSE: A 6-amino-N-hydroxyhexanamide compound is provided to ensure strong cell proliferation inhibitory power by inhibiting enzyme activity of histone deacetylase, thereby enabling use as anti-cancer drug or enzyme activity inhibitory agent of histone deacetylase. CONSTITUTION: A compound is selected from a 6-amido-N-hydroxyhexanamide compound represented by chemical formula 1 and pharmaceutically acceptable salts thereof. In chemical formula 1, X is a single bond or selected from the group of C1-6 alkylenyl; and R is hydroxy, C3-8 cycloalkyl, C3-8 cycloalkenyl, C1-6 alkoxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, 5-7-membered aryl, 5-7-membered heteroaryl including 1-3 hetero atoms selected from N and O, and 5-7-membered heterocycloalkyl including 1-3 hetero atoms selected from N and O.
Abstract translation: 目的：提供6-氨基-N-羟基己酰胺化合物，以通过抑制组蛋白脱乙酰酶的酶活性来确保强的细胞增殖抑制能力，从而可用作组蛋白脱乙酰酶的抗癌药物或酶活性抑制剂。 构成：化合物选自由化学式1表示的6-氨基-N-羟基己酰胺化合物及其药学上可接受的盐。 在化学式1中，X是单键或选自C 1-6亚烷基; 和R为羟基，C 3-8环烷基，C 3-8环烯基，C 1-6烷氧基，氨基，C 1-6烷基氨基，二（C 1-6烷基）氨基，5-7元芳基，5-7元杂芳基，包括 1-3个选自N和O的杂原子和包含1-3个选自N和O的杂原子的5-7元杂环烷基。
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2.发明授权
公开(公告)号：KR101109122B1
公开(公告)日：2012-06-12
申请号：KR1020090105096
申请日：2009-11-02
Applicant: 한국화학연구원
IPC: C07C239/14 , C07C231/14 , A61K31/165 , A61P35/00
Abstract: PURPOSE: A 6-amido-n-hydroxyhexanamide compound is provided to selectively induce the terminal differentiation of tumor cell by effectively inhibiting enzyme activity of histone deacetylase, and to inhibit the proliferation of tumor cell. CONSTITUTION: A compound is selected from a 6-amido-n-hydroxyhexanamide compound represented by chemical formula 1 and pharmaceutically acceptable salts thereof. In chemical formula 1, X is selected from a single bond or the group of C1-6 alkylenyl; R is amino, C1-6 alkylamino, di(C1-6 alkyl)amino, 5-9-membered aryl, 5-9-membered aryl C1-6 alkyl, 5-9-membered aryl C1-6 alkyloxy, 5-9-membered heteroaryl including 1-3 hetero atoms selected from N and O, and 5-7-membered heterocycloalkyl including 1-3 hetero atoms selected from N and O.
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3.发明授权
公开(公告)号：KR101116754B1
公开(公告)日：2012-03-13
申请号：KR1020090105097
申请日：2009-11-02
Applicant: 한국화학연구원
IPC: C07C239/14 , C07C231/14 , A61K31/165 , A61P35/00
Abstract: 본 발명은 신규한 6-아미노-
N -하이드록시헥산아마이드 화합물 및 약학적으로 허용 가능한 이의 염, 이 화합물의 제조방법, 그리고 이 화합물을 유효성분으로 하는 약학조성물에 관한 것이다.
본 발명의 6-아미노-
N -하이드록시헥산아마이드 화합물 및 약학적으로 허용 가능한 이의 염은 히스톤 디아세틸라제의 효소활성을 저해하므로 종양세포의 증식 억제하는 약물로 유용하게 사용될 수 있다.
히스톤 디아세틸라제, 항암, 6-아미노-N-하이드록시헥산아마이드-
4.发明公开
公开(公告)号：KR1020110048336A
公开(公告)日：2011-05-11
申请号：KR1020090105096
申请日：2009-11-02
Applicant: 한국화학연구원
IPC: C07C239/14 , C07C231/14 , A61K31/165 , A61P35/00
Abstract: PURPOSE: A 6-amido-n-hydroxyhexanamide compound is provided to selectively induce the terminal differentiation of tumor cell by effectively inhibiting enzyme activity of histone deacetylase, and to inhibit the proliferation of tumor cell. CONSTITUTION: A compound is selected from a 6-amido-n-hydroxyhexanamide compound represented by chemical formula 1 and pharmaceutically acceptable salts thereof. In chemical formula 1, X is selected from a single bond or the group of C1-6 alkylenyl; R is amino, C1-6 alkylamino, di(C1-6 alkyl)amino, 5-9-membered aryl, 5-9-membered aryl C1-6 alkyl, 5-9-membered aryl C1-6 alkyloxy, 5-9-membered heteroaryl including 1-3 hetero atoms selected from N and O, and 5-7-membered heterocycloalkyl including 1-3 hetero atoms selected from N and O.
Abstract translation: 目的：提供6-氨基 - 正 - 羟基己酰胺化合物，通过有效抑制组蛋白脱乙酰酶的酶活性，抑制肿瘤细胞的增殖，选择性诱导肿瘤细胞的末端分化。 构成：化合物选自由化学式1表示的6-氨基 - 正 - 羟基己酰胺化合物及其药学上可接受的盐。 在化学式1中，X选自单键或C1-6亚烷基; R为氨基，C 1-6烷基氨基，二（C 1-6烷基）氨基，5-9元芳基，5-9元芳基C 1-6烷基，5-9元芳基C 1-6烷氧基，5-9 包括1-3个选自N和O的杂原子的杂芳基和包含1-3个选自N和O的杂原子的5-7元杂环烷基。
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