公开(公告)号：KR1020040050998A

公开(公告)日：2004-06-18

申请号：KR1020020078815

申请日：2002-12-11

Applicant: 한국화학연구원

Inventor： 박대철 ,  백진욱 ,  박양진 ,  박주은

IPC: C07C67/38

CPC classification number: Y02P20/544

Abstract: PURPOSE: A method for preparing an ester derivative by using supercritical carbon dioxide as a reaction solvent is provided, to prevent the problems such as toxicity, corrosion and flammability due to the use of an organic solvent. CONSTITUTION: The method comprises the step of preparing an ester derivative from an olefin by using a palladium compound as a catalyst, a phosphine ligand material as an electron donor, an acid material as a reaction accelerator and supercritical fluid as a reaction solvent (See the reaction scheme II), wherein R is an alkyl or aryl group substituted with a functional group. Preferably the supercritical fluid is carbon dioxide. Preferably the acid material is p-toluenesulfonic acid; the palladium compound is selected from the group consisting of palladium acetate (Pd(OAc)2), palladium trifluoroacetate (Pd(tfOAc)2) and tetrakis(triphenylphosphine) palladium (Pd(PPh3)4); and the phosphine ligand material is selected from the group consisting of PPh3, P(p-toly)3, P(p-ClC6H4)3, P(p-FC6H4)3 and P(p-CF3(C6H4))3.

Abstract translation: 目的：提供通过使用超临界二氧化碳作为反应溶剂制备酯衍生物的方法，以防止由于使用有机溶剂而引起的毒性，腐蚀和可燃性等问题。 方案：该方法包括通过使用钯化合物作为催化剂，作为电子给体的膦配体材料，作为反应促进剂的酸性材料和作为反应溶剂的超临界流体，从烯烃制备酯衍生物的步骤（参见 反应方案II），其中R是被官能团取代的烷基或芳基。 优选地，超临界流体是二氧化碳。 优选酸性物质是对甲苯磺酸; 钯化合物选自乙酸钯（Pd（OAc）2），三氟乙酸钯（Pd（tfOAc）2）和四（三苯基膦）钯（Pd（PPh 3）4））。 膦配体材料选自PPh 3，P（p-toly）3，P（p-ClC 6 H 4）3，P（p-FC 6 H 4）3和P（p-CF 3（C 6 H 4））3。