公开(公告)号：WO2022270994A1

公开(公告)日：2022-12-29

申请号：PCT/KR2022/009087

申请日：2022-06-24

Applicant: 한국화학연구원 ,  주식회사 유빅스테라퓨틱스

Inventor： 김필호 ,  조성윤 ,  하재두 ,  박지훈 ,  황종연 ,  김현진 ,  이송희 ,  임예슬 ,  김한울 ,  유선미 ,  서범선 ,  박지윤 ,  류제호 ,  안정민 ,  문희정 ,  이호현

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P25/16

Abstract: 본 발명은 신규한 헤테로사이클릭 화합물 및 이를 포함하는 암, 자가면역질환 및 염증성 질환 예방 또는 치료용 조성물에 관한 것으로, 본 발명의 신규한 헤테로사이클릭 화합물은 유비퀴틴 프로테오좀 경로를 통해 브루톤 티로신 키나제 (Bruton's tyrosine kinase; BTK) 분해작용 효과를 가지고 있는 이작용성 화합물로서 암, 자가면역질환 및 파킨슨 병 예방 또는 치료용 조성물로 유용하게 사용가능하다.

公开(公告)号：KR100424392B1

公开(公告)日：2004-03-24

申请号：KR1020010041239

申请日：2001-07-10

Applicant: 한국화학연구원

Inventor： 안종웅 ,  이호현 ,  노재성 ,  이계형 ,  이정옥 ,  최상운 ,  권중호

IPC: A61K31/165

Abstract: PURPOSE: A pharmaceutical composition containing myxochelin-A which exhibits excellent anticancer activity against human cancer cells, together with excellent antioxidant activity as a main component is provided which can be effectively used as an effective antioxidant and anticancer agent. CONSTITUTION: The pharmaceutical composition contains myxochelin-A of formula 1 obtained by being separated from myxobacteria or being chemically synthesized or semisynthesized. The myxochelin-A is purely separated by the steps of: separating a biomass and absorption resin by culturing Angiococcus disciformis strains as myxobacteria in the presence of absorption resin and centrifuging a culture solution; adding an organic solvent, preferably a mixed solvent of acetone and methanol; extracting and filtering to remove the biomass and absorption resin; preparing an active fraction by concentrating the filtrate under reduced pressure and extracting a crude extract in an organic solvent; and successively performing silica gel liquid chromatography and recycling preparative HPLC.

Abstract translation: 目的：提供一种药物组合物，其含有对人癌细胞具有优异的抗癌活性以及优异的抗氧化活性作为主要组分的粘液溶血素A，其可以有效地用作有效的抗氧化剂和抗癌剂。 组成：药物组合物含有通过从粘细菌分离或化学合成或半合成获得的式1的粘多糖蛋白-A。 通过在吸附树脂存在下离心培养溶液培养作为粘细菌的粘细菌属细菌菌株来分离生物质和吸附树脂，纯粹分离粘液粘连素-A; 加入有机溶剂，优选丙酮和甲醇的混合溶剂; 提取并过滤去除生物质和吸收树脂; 通过在减压下浓缩滤液并在有机溶剂中萃取粗提取物来制备活性部分; 并连续进行硅胶液相色谱和再循环制备型HPLC。

公开(公告)号：KR1020030005787A

公开(公告)日：2003-01-23

申请号：KR1020010041239

申请日：2001-07-10

Applicant: 한국화학연구원

Inventor： 안종웅 ,  이호현 ,  노재성 ,  이계형 ,  이정옥 ,  최상운 ,  권중호

IPC: A61K31/165

Abstract: PURPOSE: A pharmaceutical composition containing myxochelin-A which exhibits excellent anticancer activity against human cancer cells, together with excellent antioxidant activity as a main component is provided which can be effectively used as an effective antioxidant and anticancer agent. CONSTITUTION: The pharmaceutical composition contains myxochelin-A of formula 1 obtained by being separated from myxobacteria or being chemically synthesized or semisynthesized. The myxochelin-A is purely separated by the steps of: separating a biomass and absorption resin by culturing Angiococcus disciformis strains as myxobacteria in the presence of absorption resin and centrifuging a culture solution; adding an organic solvent, preferably a mixed solvent of acetone and methanol; extracting and filtering to remove the biomass and absorption resin; preparing an active fraction by concentrating the filtrate under reduced pressure and extracting a crude extract in an organic solvent; and successively performing silica gel liquid chromatography and recycling preparative HPLC.

Abstract translation: 目的：提供能够有效地用作有效的抗氧化剂和抗癌剂的含有对人类癌细胞具有优异抗癌活性的粘液素-A的药物组合物，以及优异的抗氧化活性为主要成分。 构成：药物组合物含有通过与粘液细菌分离或化学合成或半合成获得的式1的粘液素-A。 通过以下步骤纯化粘液素-A：通过在吸收树脂存在下培养球状球形细菌菌株作为粘液细菌分离生物质和吸收树脂并离心培养液; 加入有机溶剂，优选丙酮和甲醇的混合溶剂; 提取和过滤除去生物质和吸收树脂; 通过减压浓缩滤液并在有机溶剂中萃取粗提取物制备活性级分; 并依次进行硅胶液相色谱和再循环制备型HPLC。