公开(公告)号：KR100501829B1

公开(公告)日：2005-07-20

申请号：KR1020010045954

申请日：2001-07-30

Applicant: 한국화학연구원

Inventor： 김은경 ,  이효원

IPC: C07D409/14

CPC classification number: C07D333/54 ,  C07D333/12 ,  C07D333/16 ,  C07D333/22 ,  C07D333/56 ,  C07D333/60 ,  C07D409/14 ,  G11B7/244 ,  G11B7/2531 ,  G11B7/2532

Abstract: 본 발명은 디아릴에텐 유도체와 이를 이용한 광변색 박막에 관한 것으로서, 더욱 상세하게는 결정이나 응집이 잘 일어나지 않는 디아릴에텐 유도체를 기판 위에 증착시켜 박막을 제조함으로써, 종래 광변색 화합물 외에 수지 등이 혼합된 박막과 달리 고농도의 광변색 화합물로 구성될 수 있어 나노미터 수준까지 광변색 효과를 유도할 수 있을 뿐 아니라 균일한 감도를 나타내며, 기존의 증착 방법에 비해 작업성이 향상될 뿐 아니라 투광성이 우수하고 가역적으로 광신호를 제어할 수 있어 광에 의한 색변화, 정보의 기록 및 광신호의 전달 매체로 널리 활용될 수 있는 디아릴에텐 유도체와 이를 이용한 광변색 박막에 관한 것이다.

公开(公告)号：KR1020040089887A

公开(公告)日：2004-10-22

申请号：KR1020030023721

申请日：2003-04-15

Applicant: 이효원 ,  한국화학연구원

Inventor： 이효원 ,  최일영 ,  홍용덕

IPC: C07D493/04

CPC classification number: Y02P20/55

Abstract: PURPOSE: A process for preparing epothilone derivatives is provided, thereby preparing epothilone derivatives having improved anticancer activity in higher purity and yield, so that the process can be useful for development of anticancer drugs having improved activity. CONSTITUTION: The process for preparing epothilone derivatives of formula (1b) comprises the steps of: (i) aldol condensation reacting ketonic acid derivative of formula (2) with phenylsulfone substituted aldehyde derivative of formula (3) to prepare phenylsulfone substituted hydroxy ketonic acid derivative of formula (4); (ii) removing phenylsulfone(-SO2Ph) from the compound of formula (4) to prepare hydroxy ketonic acid derivative of formula (5) with stereo selectivity; (iii) reacting the compound of formula (5) with thiazole alcohol derivative of formula (6) to prepare ester derivative of formula (7); (iv) double bond binding reaction of the compound of formula (7) using Grubbs catalyst to remove a protecting group(TBS), thereby preparing deoxyepothilone compound of formula (1a); and (v) epoxidation of the deoxyepothilone compound of formula (1a).

Abstract translation: 目的：提供制备埃坡霉素衍生物的方法，从而制备具有更高纯度和产率的改善的抗癌活性的埃坡霉素衍生物，因此该方法可用于开发具有改善活性的抗癌药物。 构成：制备式（1b）的埃坡霉素衍生物的方法包括以下步骤：（i）将式（2）的酮酸衍生物与式（3）的苯基砜取代的醛衍生物进行醛醇缩合反应以制备苯基砜取代的羟基酮酸衍生物 的式（4）; （ii）从式（4）化合物中除去苯基砜（-SO 2 Ph），以立体选择性制备式（5）的羟基酮酸衍生物; （iii）使式（5）的化合物与式（6）的噻唑醇衍生物反应制备式（7）的酯衍生物; （ⅳ）使用Grubbs催化剂除去保护基团（TBS）的式（7）化合物的双键结合反应，由此制备式（1a）的脱氧异硫酚化合物; 和（v）式（1a）的脱氧抗坏血酸酮化合物的环氧化。

公开(公告)号：KR1020040010865A

公开(公告)日：2004-02-05

申请号：KR1020020043890

申请日：2002-07-25

Applicant: 한국화학연구원

Inventor： 김은경 ,  이효원 ,  김동철 ,  김동호

IPC: C07C327/22

Abstract: PURPOSE: Provided are sulfur-containing acrylic or methacrylic compounds of general formula 1 and a preparation method thereof, which can give plastic materials improved in transparency, heat resistance, hardness, as well as refractive index and abbe value, thus they are suitable to use in highly integrated optical parts. CONSTITUTION: The sulfur-containing acrylic or methacrylic compounds are represented by general formula 1, wherein each R1 and R6 is independently H or -CH3; X1 is -O-, -S-, -SO2-, -C(=O)-, and formula 1-1; each a and b is an integer ranging from 0 to 2, provided that they satisfies a+b=2; each R2 and R5 is independently (CH2)n1-O, (CH2CH2O)n2 or -(CH-CH2-O)n3-, wherein the oxygen atom is connected to the C=O side; each R3, R4 and R12 is independently, -C6H4-, -(CH2)n4-, -(CH2)n6-(SCH2CH2)n5-, -C6H4-CH2- or -CH2S-C6H4-CH2, or when X1 is -P=SR7-, R3 and R4 are -CH2CH2O-, -(CH2)n9-(CH2CH2S)n10- or -C6H4S, wherein the benzene ring is connected to -SCO- side; R7 is (C1-C20)alkylthio ether, -O-C6H4-S0CH3, -O-C6H4-OCH3 or -C6H4-C6H5; each R8 and R9 is independently linear (C1-C20)alkyl or (C3-C10)cyclic alkyl, phenyl, -CH2-C6H5 or CF3; each R10 and R11 is H, (C1-C20)alkyl, (C3-C10)cyclic alkyl, phenyl or benzyl, or linked together with N to form (C3-C10)cyclic amine; each X2 and X3 is a bond, or S or O; each of n1 to n4, and n6 is an integer ranging from 0 to 20; each n5, n7, and n9 is an integer of 0 to 10; and each n8 and n10 is an integer of 1 to 10.

Abstract translation: 目的：提供通式1的含硫丙烯酸或甲基丙烯酸类化合物及其制备方法，其可使塑料材料的透明度，耐热性，硬度以及折射率和阿贝值提高，因此它们适用于 在高度集成的光学部件。 构成：含硫丙烯酸或甲基丙烯酸化合物由通式1表示，其中每个R 1和R 6独立地为H或-CH 3; X 1是-O - ， - S - ， - SO 2 - ， - C（= O） - 和式1-1; 每个a和b是0至2的整数，条件是它们满足+ b = 2; 每个R2和R5独立地为（CH2）n1-O，（CH2CH2O）n2或 - （CH-CH2-O）n3-，其中氧原子连接到C = O侧; 每个R 3，R 4和R 12独立地为-C 6 H 4 - ， - （CH 2）n 4-， - （CH 2）n 6 - （SCH 2 CH 2）n 5 - ， - C 6 H 4 -CH 2 - 或-CH 2 S-C 6 H 4 -CH 2， P = SR7-，R3和R4是-CH2CH2O-， - （CH2）n9-（CH2CH2S）n10-或-C6H4S，其中苯环连接到-SCO-侧; R7是（C1-C20）烷硫醚，-O-C6H4-SOCH3，-O-C6H4-OCH3或-C6H4-C6H5; 每个R 8和R 9独立地为直链（C 1 -C 20）烷基或（C 3 -C 10）环烷基，苯基，-CH 2 -C 6 H 5或CF 3; 每个R 10和R 11是H，（C 1 -C 20）烷基，（C 3 -C 10）环烷基，苯基或苄基，或与N一起连接形成（C 3 -C 10）环胺; 每个X2和X3是键或S或O; n1〜n4各自为n6，为0〜20的整数。 每个n5，n7和n9是0至10的整数; n8和n10为1〜10的整数。

公开(公告)号：KR100491337B1

公开(公告)日：2005-05-24

申请号：KR1020030023721

申请日：2003-04-15

Applicant: 이효원 ,  한국화학연구원

Inventor： 이효원 ,  최일영 ,  홍용덕

IPC: C07D493/04

CPC classification number: Y02P20/55

Abstract: 본 발명은 에포싸일론 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는 알돌축합 반응에 사용되어지는 알데하이드 화합물과 케톤 화합물의 구조를 특이성 있게 고안하여 반응에 사용함으로써 부분이성질체 중 원하는 이성질체의 비율이 절대적으로 우위에 있도록 합성하여 용이하게 이성질체를 분리할 수 있도록 하는 등의 일련의 제조방법의 특징으로 인하여 차세대 항암제로 유력한 에포싸일론(Epothilone) 유도체를 고 순도 및 고 수율로 전합성하는 제조방법에 관한 것이다.

公开(公告)号：KR100376285B1

公开(公告)日：2003-03-17

申请号：KR1020020068045

申请日：2002-11-05

Applicant: 한국화학연구원

Inventor： 김은경 ,  이효원

IPC: C08F263/08

Abstract: PURPOSE: A method for preparing a photochromic plastic lens is provided, to obtain a photochromic plastic lens which has good refractive index, surface hardness and photochromism lifetime and whose refractive index can be controlled widely by the change of the composition, by varying the curing temperature and time. CONSTITUTION: The method comprises leaving a photochromic resin composition at a temperature of a room temperature to 70 deg.C for 30-360 min to initiate the degradation reaction of an initiator; maintaining the temperature at 70-80 deg.C for 110-180 in; maintaining the temperature at 85-95 deg.C for 110-130 min; maintaining the temperature at 110-130 deg.C for 30-240 min; and cooling the thermally cured one naturally. The photochromic resin composition comprises 100 parts by weight of at least one monomer selected from the aromatic radical polymerizable monomers represented by the formula 1; 0.001-90 parts by weight of at least one photochromic compound selected from the group consisting of diarylethene-based one, Spirobenzopyran-based one and diazo-based one absorbing the light with the wavelength of 250 nm or more; and 0.1-10 parts by weight of a photoinitiator.

Abstract translation: 目的：提供一种制备光致变色塑料透镜的方法，以获得具有良好折射率，表面硬度和光致变色寿命并且可通过改变组成而改变其折射率的光致变色塑料透镜，其通过改变固化温度 和时间。 组成：该方法包括将光致变色树脂组合物在室温至70℃的温度下放置30-360分钟以引发引发剂的降解反应; 保持温度在70-80℃，110-180英寸; 保持温度在85-95℃110-130分钟; 保持温度在110-130℃30-240分钟; 并自然冷却热固化的。 该光致变色树脂组合物包含100重量份的至少一种选自式1表示的可芳族自由基聚合单体的单体; 0.001-90重量份的至少一种选自二芳基乙烯基，基于螺二苯并吡喃的和基于重氮的吸收波长为250nm或更大的光的光致变色化合物; 和0.1-10重量份的光引发剂。

公开(公告)号：KR1020030012090A

公开(公告)日：2003-02-12

申请号：KR1020010045954

申请日：2001-07-30

Applicant: 한국화학연구원

Inventor： 김은경 ,  이효원

IPC: C07D409/14

CPC classification number: C07D333/54 ,  C07D333/12 ,  C07D333/16 ,  C07D333/22 ,  C07D333/56 ,  C07D333/60 ,  C07D409/14 ,  G11B7/244 ,  G11B7/2531 ,  G11B7/2532

Abstract: PURPOSE: Provided are diarylethene derivatives to which crystallization or condensation hardly happens and a photochromic thin film using the same by depositing the diarylethene derivatives on a base plate. Therefore the thin film induces photochromic effect on nanometers level, has regular sensitivity and excellent light transmission, and controls photosignals. CONSTITUTION: The photochromic diarylethene derivative is represented by the formula(1), wherein R1 is a binding line, a C1-C3 alkylene group or a fluorine substituted C1-C3 alkylene group, Ar¬1 and Ar¬2 are individually represented by the formula(2) or (3), and Z is a fluorine substituted or unsubstituted methylene group or carbonyl group. The photochromic thin film is manufactured by depositing the compound of the formula(1) on a base plate.

Abstract translation: 目的：提供几乎不发生结晶或凝结的二芳基乙烯衍生物和使用其的光致变色薄膜，将二芳基乙烯衍生物沉积在基板上。 因此，薄膜在纳米级上引起光致变色效应，具有常规的灵敏度和优异的光透射率，并控制光信号。 构成：光致变色二烯丙烯衍生物由式（1）表示，其中R1是结合线，C1-C3亚烷基或氟取代的C1-C3亚烷基，Ar1和Ar2分别由 式（2）或（3），Z为氟取代或未取代的亚甲基或羰基。 通过将式（1）的化合物沉积在基板上来制造光致变色薄膜。

公开(公告)号：KR100047293B1

公开(公告)日：1991-12-27

申请号：KR1019870011356

申请日：1987-10-13

Applicant: 한국화학연구원 ,  씨제이 주식회사

Inventor： 이효원 ,  김성기

IPC: C07D317/12

公开(公告)号：KR1019890006611A

公开(公告)日：1989-06-14

申请号：KR1019870011356

申请日：1987-10-13

Applicant: 한국화학연구원 ,  씨제이 주식회사

Inventor： 이효원 ,  김성기

IPC: C07D317/12

Abstract: 내용 없음

公开(公告)号：KR100390777B1

公开(公告)日：2003-07-10

申请号：KR1020000078674

申请日：2000-12-19

Applicant: 한국화학연구원

Inventor： 최일영 ,  정명희 ,  양준연 ,  이효원

IPC: C07D215/22

Abstract: PURPOSE: Provided is a process for preparing pyridone derivative represented by the formula(1) and useful as a therapeutics of Alzheimer's disease(AD). CONSTITUTION: The process for preparing pyridione derivative of the formula(1) comprises the steps of; reacting 1,4-cyclohexanedione monoketal of the formula(2) with secondary amine under acid catalyst; then treating the resultant with propiolamide of the formula(3) to obtain the compound of the formula(1). In the formulae, R1 and R2 represent individually C1-C6 alkyl group or R1 and R2 bind together to form 5-8 membered hetero ring.

Abstract translation: 目的：提供一种制备式（1）代表的吡啶酮衍生物并用作阿尔茨海默病（AD）治疗剂的方法。 构成：制备式（1）的吡啶酮衍生物的方法包括以下步骤： 在酸催化剂下使式（2）的1,4-环己烷二酮单缩酮与仲胺反应; 然后用式（3）丙酰胺处理得到式（1）化合物。 在式中，R 1和R 2分别代表C 1 -C 6烷基或R 1和R 2结合在一起形成5-8元杂环。

公开(公告)号：KR100390772B1

公开(公告)日：2003-07-10

申请号：KR1020000050148

申请日：2000-08-28

Applicant: 한국화학연구원

Inventor： 김은경 ,  이효원

IPC: C08F263/08

Abstract: PURPOSE: Provided is a photochromic resin composition excellent in refraction rate, surface hardness, and repeatability of photo-discoloration, which can be used for functional optical lenses, filters, imaging, display elements or photonic integrated elements, photo discs, or optically recording media. CONSTITUTION: The photochromic resin composition contains: 100pts.wt. of at least one kind of monomer selected from aromatic radical polymerizable monomers represented by the formula 1; 0.001-90pts.wt. of at least one photochromic compound selected from the group consisting of a diarylethene, a spirobenzopyran, and a diazo, which has an absorption-wavelength of 250nm or more; 0.1-10pts.wt. of a photo-initiator such as 2,2'-azobis isobutyro nitrile(AIBN) and benzoyl peroxide(BPO). In the formula, R1 and R2 are identically or differently H or C1-C4 alkyl, R3 and R4 are the same as the R1 and R2 or C1-C4 haloalkyl, R5 is H, C1-C4 alkyl, and etc., Z is a direct bond, -S-, or -O-, Y is a direct bond, -S-, -SO2-, -O-C(=O)-, and etc., X is H, -O-, -S-, -SO2-, and etc., k is 0 or 1, l is 1 or 2, m is 0, 1, or 2, and n is 0 or an integer of 1-20.

Abstract translation: 目的：提供可用于功能性光学透镜，滤光片，成像，显示元件或光子集成元件，光盘或光学记录介质的折光率，表面硬度和光致变色可重复性优异的光致变色树脂组合物 。 构成：光致变色树脂组合物含有：100pts.wt。 的至少一种选自由式1表示的可芳族自由基聚合单体的单体; 0.001-90pts.wt。 的至少一种选自二芳基乙烯，螺二苯并吡喃和重氮基的光致变色化合物，其具有250nm或更大的吸收波长; 0.1-10pts.wt。 的光引发剂如2,2'-偶氮二异丁腈（AIBN）和过氧化苯甲酰（BPO）。 在该式中，R1和R2相同或不同地为H或C1-C4烷基，R3和R4与R1和R2或C1-C4卤代烷基相同，R5为H，C1-C4烷基等，Z为 直接键，-S-或-O-，Y为直接键，-S - ， - SO2-，-OC（= O） - 等，X为H，-O - ， - S- -SO 2 - 等，k为0或1，l为1或2，m为0,1或2，并且n为0或1至20的整数。