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公开(公告)号:KR1019920005647B1
公开(公告)日:1992-07-11
申请号:KR1019900009745
申请日:1990-06-29
Applicant: 한국화학연구원
IPC: A61K9/52
Abstract: The method for producing a controlled release-type microcapsule is characterized by (a) adding an aqueous soln. of water- soluble drug and diethylene triamine (or tetraethylene pentamine) to an organic soln. of polyvinyl pyrrolidone surfactant and cebacoyl (or terephthaloyl adipoyl, isophthaloyl) chloride, (b) agitating the mixed soln. to obtain a polyamide microcapsule by the interfacial polymerization, (c) coating the capsule with a chloroform soln. contg. C12-18 fatty acid as an organic conating agent, and (d) drying the coated capsule.
Abstract translation: 控制释放型微胶囊的制造方法的特征在于:(a)添加水性溶胶。 的水溶性药物和二亚乙基三胺(或四亚乙基五胺)与有机溶胶接触。 的聚乙烯吡咯烷酮表面活性剂和癸二酰基(或对苯二甲酰己二酰基,间苯二酰基)氯化物,(b)搅拌混合溶胶。 通过界面聚合获得聚酰胺微胶囊,(c)用氯仿溶胶包被胶囊。 contg。 C12-18脂肪酸作为有机锥剂,和(d)干燥涂覆的胶囊。
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