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公开(公告)号：KR101069590B1
公开(公告)日：2011-10-05
申请号：KR1020110057658
申请日：2011-06-14
Applicant: 한국화학연구원 , 광운대학교 산학협력단
IPC: C12N15/115 , C12Q1/68 , C07H21/04
Abstract: 본발명은 CEA에특이적으로결합하는단일가닥 DNA를포함하는압타머에관한것이다. 본발명에서 CEA에특이적으로결합하는단일가닥 DNA는서열번호 1 내지서열번호 3의단일가닥 DNA 가이루는 3차원구조가 CEA와의특이적인결합을달성하게하는것으로생각된다. 본발명의 DNA 압타머를이용하는바이오센서는 DNA 서열로이루어져단백질서열로이루어진종래의진단시약에비해활성을장기간유지할수 있고, 열등의환경조건에도변하지않아안정적으로장기간보관할수 있다.
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Patent Agency Ranking
公开(公告)号：KR101069591B1
公开(公告)日：2011-10-05
申请号：KR1020110057659
申请日：2011-06-14
Applicant: 한국화학연구원 , 광운대학교 산학협력단
IPC: C12N15/115 , C12Q1/68
Abstract: 본발명은 CEA에특이적으로결합하는단일가닥 DNA를포함하는압타머에관한것이다. 본발명에서 CEA에특이적으로결합하는단일가닥 DNA는서열번호 1 내지서열번호 3의단일가닥 DNA 가이루는 3차원구조가 CEA와의특이적인결합을달성하게하는것으로생각된다. 본발명의 DNA 압타머를이용하는바이오센서는 DNA 서열로이루어져단백질서열로이루어진종래의진단시약에비해활성을장기간유지할수 있고, 열등의환경조건에도변하지않아안정적으로장기간보관할수 있다.
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公开(公告)号：KR1020100122223A
公开(公告)日：2010-11-22
申请号：KR1020090041157
申请日：2009-05-12
Applicant: 한국화학연구원 , 광운대학교 산학협력단
CPC classification number: C12N15/11 , C12N15/115 , C12N2310/16 , C12Q1/6816 , C12Q2525/205
Abstract: PURPOSE: An aptamer containing a single strand DNA which specficially binds to CEA is provided to maintaining long-term activation. CONSTITUTION: An aptamer for CEA(carcinoembryonic antigen) contains a polynucleotide having DNA sequence of sequence number 1. The aptamer for CEA contains a polynucleotide having DNA sequence of sequence number 2. The aptamer for CEA contains a polynucleotide having DNA sequence of sequence number 3. The CEA is a tumor marker.
Abstract translation: 目的：提供含有特异性结合CEA的单链DNA的适体，以保持长期活化。 构成：用于CEA（癌胚抗原）的适配体含有具有序列号1的DNA序列的多核苷酸.CEA适配体含有具有序列号2的DNA序列的多核苷酸.CEA适配体含有具有序列号3的DNA序列的多核苷酸 CEA是肿瘤标志物。
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公开(公告)号：KR1020110074504A
公开(公告)日：2011-06-30
申请号：KR1020110057659
申请日：2011-06-14
Applicant: 한국화학연구원 , 광운대학교 산학협력단
IPC: C12N15/115 , C12Q1/68
CPC classification number: C12N15/115 , C12N2310/16 , C12Q1/6886 , C12Q2525/205 , G01N33/57473
Abstract: PURPOSE: An aptamer containing a single strand DNA which specifically binds to CEA is provided to ensure stable long-term storage regardless of environmental condition such as heat. CONSTITUTION: An aptamer which specifically binds to CEA(carcinoembryonic antigen) comprises a polynucleotide having a DNA sequence of sequence number 3. The CEA is a well-known tumor marker. The polynucleotide of DNA sequence is selected by SELEX method. A biosensor for diagnosing cancer has the aptamer.
Abstract translation: 目的：提供含有特异性结合CEA的单链DNA的适体，以确保稳定的长期储存，而不管环境条件如热。 构成：特异性结合CEA（癌胚抗原）的适体包含具有序列号3的DNA序列的多核苷酸.CEA是众所周知的肿瘤标记物。 通过SELEX方法选择DNA序列的多核苷酸。 用于诊断癌症的生物传感器具有适配体。
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公开(公告)号：KR1020110070845A
公开(公告)日：2011-06-24
申请号：KR1020110057658
申请日：2011-06-14
Applicant: 한국화학연구원 , 광운대학교 산학협력단
IPC: C12N15/115 , C12Q1/68 , C07H21/04
CPC classification number: C12N15/115 , C12N2310/16 , C12Q1/6886 , C12Q2525/205 , G01N33/57473
Abstract: PURPOSE: A biosensor using an aptamer containing a single strand DNA which specifically binds to CEA is provided to ensure long-term maintenance of activity and long-term storage. CONSTITUTION: An aptamer containing a single strand DNA which binds to CEA(carcinoembryonic antigen) comprises a polynucleotide of sequence number 2. A polynucleotide which has high affinity with CEA and is used as aptamer contains DNA sequence of sequence number 2. A method for selecting the polynucleotide of DNA sequence is performed by SELEX method.
Abstract translation: 目的：提供使用含有特异性结合CEA的单链DNA的适体的生物传感器，以确保长期维持活性和长期储存。 构成：含有与CEA（癌胚抗原）结合的单链DNA的适体包含序列号2的多核苷酸。与CEA具有高亲和性并用作适体的多核苷酸含有序列号2的DNA序列。 DNA序列的多核苷酸通过SELEX方法进行。
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