코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
    3.
    发明公开
    코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법 有权
    纳米内核核壳纳米颗粒及其制备方法

    公开(公告)号:KR1020120056024A

    公开(公告)日:2012-06-01

    申请号:KR1020100117527

    申请日:2010-11-24

    CPC classification number: G01N21/658 A61K49/0002 G01N33/54346 G01N2021/653

    Abstract: PURPOSE: A method for preparing nanoparticles having a nanogap between a core and a shell is provided to amplify signals and to ensure high reproducibility. CONSTITUTION: A nanoparticle contains a core and a shell surrounding the core and has a nanogap between the core and shell. The core and shell are connected by a nano bridge. The diameter of the core is 1nm-900nm. The thickness of the shell is 1nm-900nm. The core and shell are formed of metal with a surface plasmon resonance. An oligonucleotide is adhered on the surface of the core by electrostatic attraction. A method for preparing the nanoparticles comprises: a step of modifying the oligonucleotide on the core; and a step of forming the shell on the core.

    Abstract translation: 目的:提供一种在核心和壳体之间具有纳米隙的纳米颗粒的制备方法,以扩增信号并确保高的再现性。 构成:纳米颗粒包含核心和围绕核心的壳体,并且在核心和壳体之间具有纳米隙。 核心和壳体通过纳米桥连接。 芯的直径为1nm〜900nm。 壳的厚度为1nm-900nm。 核和壳由具有表面等离子体共振的金属形成。 通过静电吸引将寡核苷酸附着在芯的表面上。 制备纳米颗粒的方法包括:修饰核心上的寡核苷酸的步骤; 以及在芯上形成壳的步骤。

    나노 입자-핵산 복합체 및 이를 이용한 표적 핵산의 선형화 방법
    7.
    发明公开
    나노 입자-핵산 복합체 및 이를 이용한 표적 핵산의 선형화 방법 无效
    纳米核酸复合物及其使用目标核酸的线性化方法

    公开(公告)号:KR1020120100629A

    公开(公告)日:2012-09-12

    申请号:KR1020110019648

    申请日:2011-03-04

    Abstract: PURPOSE: A nanoparticle-nucleic acid complex and a method for linearizing target nucleic acids using the same are provided to enable effectively sequencing and mapping of the target nucleic acids. CONSTITUTION: A nanoparticle-nucleic acid complex contains nanoparticles(100) in which two or more protection sequence parts(110) and a probe sequence part(120) are fixed. The protection sequence parts are fixed at the nanoparticfles at one end and have a single strand nucleic acid containing a random base sequence. The probe sequence part is fixed at the nanoparticles at one end and has a single strand nucleic acid containing a base sequenc ewhic complementarily binds to a first region(131) of connection sequence part(130). The protection sequence part further contains a spacer. The spacer binds on the surface of the nanoparticles at one end and binds the single stand nucleic acid of the production sequene at the other end.

    Abstract translation: 目的:提供纳米颗粒 - 核酸复合物和使用其的靶核酸线性化的方法,以有效地测序和测定靶核酸。 构成:纳米颗粒 - 核酸复合物含有其中固定有两个或多个保护序列部分(110)和探针序列部分(120)的纳米颗粒(100)。 保护序列部分在一端固定在纳米颗粒上,并具有含有随机碱基序列的单链核酸。 探针序列部分在一端固定在纳米颗粒上,并且具有单链核酸,其含有与连接序列部分(130)的第一区域(131)互补结合的碱基序列。 保护序列部分还包含间隔物。 间隔物在一端在纳米颗粒的表面上结合,并且在另一端结合生产顺序的单一核酸。

Patent Agency Ranking