公开(公告)号：KR1020140081687A

公开(公告)日：2014-07-01

申请号：KR1020130156409

申请日：2013-12-16

Applicant: 한국화학연구원 ,  카톨리에케 유니버시테이트 루벤

Inventor： 정영식 ,  한수봉 ,  이종교 ,  김해수 ,  신진수 ,  네이츠요한 ,  티보핸드릭얀 ,  말파니야쉬바단라다모한

IPC: C07D405/12 ,  C07D307/79 ,  A61K31/404 ,  A61P31/12

CPC classification number: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/404 ,  C07D307/79

Abstract: The present invention relates to a novel compound, a pharmaceutically acceptable salt or an optical isomer thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating viral diseases containing the same as an active ingredient. According to the present invention, the novel compound not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, thereby being effectively used as a pharmaceutical composition for preventing or treating viral diseases, such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth diseas, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

Abstract translation: 本发明涉及一种新型化合物，其药学上可接受的盐或其旋光异构体，其制备方法和用于预防或治疗含有该活性成分的病毒性疾病的药物组合物。 根据本发明，新化合物不仅具有低细胞毒性，而且对柯萨奇病毒，肠道病毒，回波病毒，脊髓灰质炎病毒和鼻病毒等小RNA病毒具有优异的抗病毒活性，有效地用作预防或治疗病毒性疾病的药物组合物 婴儿瘫痪，急性出血性结膜炎，病毒性脑膜炎，手足口病，囊泡病，甲型肝炎，肌炎，心肌炎，胰腺炎，糖尿病，流行性肌痛，脑炎，感冒，呼吸管麻痹，口蹄疫， 哮喘，慢性阻塞性肺病，肺炎，鼻窦感染或中耳炎。

公开(公告)号：KR101630243B1

公开(公告)日：2016-06-15

申请号：KR1020130156409

申请日：2013-12-16

Applicant: 한국화학연구원 ,  카톨리에케 유니버시테이트 루벤

Inventor： 정영식 ,  한수봉 ,  이종교 ,  김해수 ,  신진수 ,  네이츠요한 ,  티보핸드릭얀 ,  말파니야쉬바단라다모한

IPC: C07D405/12 ,  C07D307/79 ,  A61K31/404 ,  A61P31/12

CPC classification number: C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

Abstract: 본발명은신규한화합물, 이의약학적으로허용되는염 또는이의광학이성질체, 이의제조방법및 이를유효성분으로함유하는바이러스성질환의예방또는치료용약학적조성물에관한것으로, 본발명에따른신규한화합물은세포독성이낮을뿐만아니라, 콕싸키바이러스, 엔테로바이러스, 에코바이러스, 폴리오바이러스, 라이노바이러스등과같은피코르나바이러스에대해매우우수한항바이러스활성을가지므로, 소아마비, 급성출혈성결막염, 바이러스성수막염, 수족구병, 수포병, A형간염, 근육염, 심근염, 췌장염, 당뇨, 유행성근육통, 뇌염, 감기, 포진성구협염, 구제역, 천식, 만성폐쇄성폐질환, 폐렴, 축농증또는중이염등의바이러스성질환의예방또는치료용약학적조성물로유용하게사용될수 있다.