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公开(公告)号：KR1020110092179A
公开(公告)日：2011-08-17
申请号：KR1020100011694
申请日：2010-02-08
Applicant: 한림대학교 산학협력단
IPC: A61K36/899 , A61P3/10 , A61P3/00
Abstract: PURPOSE: A composition containing purple corn extract for suppressing diabetic renal fibrosis is provided to reduce type IV collagen generation and to relieve renal fibrosis. CONSTITUTION: A composition for suppressing diabetic renal fibrosis contains purple corn extract. The purple corn extract is prepared by mixing 100% of purple corn powder with ethanol in a weight ratio of 1:7-10, performing sonication for 20-40 minutes, centrifuging at 2500-3000rpm for 10-20 minutes, collecting supernatant, and concentrating. The composition is manufactured in the form of beverage, powder, concentrate, capsule, and medicine.
Abstract translation: 目的：提供含有用于抑制糖尿病肾纤维化的紫玉米提取物的组合物，以减少IV型胶原蛋白的产生并减轻肾纤维化。 构成：用于抑制糖尿病肾纤维化的组合物含有紫玉米提取物。 紫玉米提取物通过将100％的紫玉米粉与乙醇以1:7-10的重量比混合，超声处理20-40分钟，以2500-3000rpm离心10-20分钟，收集上清液和 集中。 该组合物以饮料，粉末，浓缩物，胶囊和药物的形式制造。
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公开(公告)号：KR1020110060993A
公开(公告)日：2011-06-09
申请号：KR1020090117494
申请日：2009-12-01
Applicant: 한림대학교 산학협력단
IPC: A61K31/37 , A61P13/12 , A61K36/484
Abstract: PURPOSE: A composition containing isoangustone A is provided to reduce collagen generation and to reduce tissue inhibitor of metalloproteinase type 2(TIMP-2) activity. CONSTITUTION: A composition for suppressing renalfibrosis or glomerulsclerosis contains isoangustone A which is an ingredient of Glycyrrhiza uralensis extract. Isoangustone A has a structure of chemical formula I. A method for isolating isoangustone A comprises: a step of extracting Glycyrrhiza uralensis roots using a solvent of hexane and ethanol by sonication for one hour; a step of decompression-concentrating the extract to prepare crude extract; and a step of performing HSCCC(High-speed countercurrent chromatography).
Abstract translation: 目的：提供含有异黄酮酮A的组合物以减少胶原蛋白的产生并减少2型金属蛋白酶（TIMP-2）活性的组织抑制剂。 构成：用于抑制肾结石病或肾小球硬化的组合物含有作为甘草提取物成分的异黄酮A。 异黄酮A具有化学式I的结构。异洋ust酮A的分离方法包括：使用己烷和乙醇的溶剂通过超声处理提取甘草根1小时的步骤; 减压浓缩提取物制备粗提物的步骤; 和进行HSCCC（高速逆流色谱法）的工序。
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公开(公告)号：KR101063524B1
公开(公告)日：2011-09-07
申请号：KR1020100011694
申请日：2010-02-08
Applicant: 한림대학교 산학협력단
IPC: A61K36/899 , A61P3/10 , A61P3/00
Abstract: 본 발명은 당뇨합병증으로 인해 초래되는 신장섬유증에 직접적으로 관련된 인간 신장 혈관간세포(Human Renal Mesangial Cell, HRMC)를 고혈당에 노출시키고 여기에 검정옥수수 추출물과 3일간 배양함으로써, 결합조직 성장인자(Connetive Tissue Growth Factor, CTGF)의 활성을 억제하고, 제 4(Ⅳ)형 콜라겐(Collagen) 생성을 감소시키며, 막형 기질단백질 분해효소(Membrane Type-1 Matrix Metalloproteinase, MT-1 MMP)의 발현을 증가시켜 만성 고혈당으로 인한 신장 섬유증을 개선시키는 검정옥수수 추출물을 함유하는 당뇨병성 신장섬유증 억제용 조성물 대한 것이다.
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