公开(公告)号：KR101217710B1

公开(公告)日：2013-01-02

申请号：KR1020100040323

申请日：2010-04-29

Applicant: 한림대학교 산학협력단

Inventor： 원무호 ,  황인구 ,  유대영 ,  유기연 ,  최정훈 ,  이충현 ,  이현주 ,  박옥규 ,  박준하

IPC: A61K36/752 ,  A61P25/00

Abstract: 본발명은레몬밤추출물을유효성분으로포함하는신경모세포분화촉진용약학조성물및 기능성식품에관한것이다. 본발명의레몬밤추출물은노화시에나타나는신경모세포의분화및 증식의감소를현저하게개선함으로써, 노화에의한신경세포분화및 증식을촉진시키기위한약학적조성물및 기능성식품으로유용하게이용될수 있다.

公开(公告)号：KR1020140030934A

公开(公告)日：2014-03-12

申请号：KR1020120097718

申请日：2012-09-04

Applicant: 한림대학교 산학협력단 ,  주식회사 바이오셀트란

Inventor： 최수영 ,  박진서 ,  음원식 ,  김대원 ,  장상호 ,  김형춘 ,  황인구 ,  신은주 ,  유대영

IPC: A61K38/10 ,  A61K38/08 ,  A61P9/10 ,  A61K38/16

CPC classification number: A61K38/10 ,  A61K38/08 ,  A61K38/16 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00

Abstract: The present invention relates to a pharmaceutical composition comprising peroxiredoxin 2 fusion protein in which a protein transport domain is covalently bonded to at least one among a N-terminal and a C-terminal of peroxiredoxin 2 protein for preventing and treating ischemic damages. The protein transport domain is either HIV-Tat peptide or PEP-1 peptide.

Abstract translation: 本发明涉及包含过氧化还原酶2融合蛋白的药物组合物，其中蛋白质转运结构域共价键合到过氧化还原酶2蛋白的N末端和C末端中的至少一个，用于预防和治疗缺血性损伤。 蛋白质转运结构域是HIV-Tat肽或PEP-1肽。

公开(公告)号：KR1020110120760A

公开(公告)日：2011-11-04

申请号：KR1020100040323

申请日：2010-04-29

Applicant: 한림대학교 산학협력단

Inventor： 원무호 ,  황인구 ,  유대영 ,  유기연 ,  최정훈 ,  이충현 ,  이현주 ,  박옥규 ,  박준하

IPC: A61K36/752 ,  A61P25/00

CPC classification number: A61K36/752 ,  A23V2200/322 ,  A61K2236/331 ,  A61K2236/333

Abstract: PURPOSE: A pharmaceutical composition containing Melissa officinalis extract for promoting neuroblast differentiation due to aging is provided. CONSTITUTION: A pharmaceutical composition for promoting differentiation and proliferation of neuroblast contains 0.01-50 wt% Melissa officinalis extract as an active ingredient, isolated from Melissa officinalis using water, low alcohol of C-C4, or mixture solvent thereof. The neurobalst is hippocampus, dentate gyrus, and subgranular zone-derived nerve stem cells. A functional food for promoting differentiation and proliferation of neurobalst contains the Melissa officinalis extract as an active ingredient.

Abstract translation: 目的：提供含有Melissa officinalis提取物的药物组合物，用于促进老化造成神经母细胞分化。 构成：用于促进成神经细胞分化和增殖的药物组合物含有0.01-50重量％的Melissa officinalis提取物作为活性成分，使用水，C-C4的低醇或其混合溶剂从Melissa officinalis中分离。 神经损伤是海马，齿状回和子颗粒区衍生的神经干细胞。 用于促进神经母细胞分化和增殖的功能性食物含有Melissa officinalis提取物作为活性成分。