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公开(公告)号：KR101336143B1
公开(公告)日：2013-12-05
申请号：KR1020110097206
申请日：2011-09-26
Applicant: 한밭대학교 산학협력단
IPC: C07D495/04 , C07C309/08 , A61K31/4365 , A61P9/00
Abstract: 본 발명은 클로피도그렐 황산수소염(Clopidogrel bisulfate)과 니코틴아마이드 또는 이소니코틴아마이드로 이루어진 클로피도그렐의 공결정, 상기한 클로피도그렐의 공결정을 활성성분으로 포함하는 약제조성물, 그리고 상기한 클로피도그렐의 공결정의 제조방법에 관한 것이다.
본 발명의 클로피도그렐의 공결정은 기존의 클로피도그렐 황산수소염과 비교하여 물리화학적으로 전혀 다른 양상을 나타낸다. 특히 본 발명의 클로피도그렐의 공결정은 열과 빛 또는 수분에 대한 안정성이 우수하고, 물에 대한 용해도가 우수하므로 약제조성물의 활성성분으로 유용하다.-
公开(公告)号：KR1020130033243A
公开(公告)日：2013-04-03
申请号：KR1020110097207
申请日：2011-09-26
Applicant: 한밭대학교 산학협력단
IPC: C07D473/34 , A61K31/52 , A61K31/675 , A61P31/12
Abstract: PURPOSE: An adefovir dipivoxil co-crystal is provided to ensure stability to heat, light, or moisture and solubility in water and to be used as an active ingredient of a pharmaceutical composition. CONSTITUTION: An adefovir dipivoxil co-crystal contains adefovir dipivoxil and a co-former selected from oxalic acid, furmaric acid, carbamazepine, L-gluamine, and L-tryptopane. A method for preparing the adefovir dipivoxil co-crystal comprises: a step of dissolving adefovir dipivoxil and a co-former selected from oxalic acid, furmaric acid, carbamazepine, L-gluamine, and L-tryptopane and forming a mixture solution; a step of generating adefovir dipivoxil co-crystal; and a step of collecting the adefovir dipivoxil co-crystal.
Abstract translation: 目的：提供阿德福韦酯共晶，以确保热，光或水分的稳定性和在水中的溶解性，并用作药物组合物的活性成分。 构成：阿德福韦酯共晶体含有阿德福韦酯和选自草酸，呋喃马来酸，卡马西平，L-葡萄糖胺酸和L-色氨酸的共同成员。 制备阿德福韦酯共晶体的方法包括：将阿德福韦酯和选自草酸，呋喃甲酸，卡马西平，L-葡萄糖胺酸和L-三苯乙胺的共成形物溶解并形成混合溶液的步骤; 产生阿德福韦酯共晶的一个步骤; 以及收集阿德福韦酯共晶体的步骤。
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公开(公告)号：KR1020130033242A
公开(公告)日：2013-04-03
申请号：KR1020110097206
申请日：2011-09-26
Applicant: 한밭대학교 산학협력단
IPC: C07D495/04 , C07C309/08 , A61K31/4365 , A61P9/00
Abstract: PURPOSE: A clopidogrel co-crystal containing clopidogrel bisulfate and nicotinamide is provided to enhance stability to heat, light, or moisture, and to ensure solubility in water. CONSTITUTION: A clopidogrel co-crystal contains clopidogrel bisulfate, and nicotinamide or isonicotinamide. A method for preparing the clopidogrel co-crystal comprises: a step of dissolving clopidogrel bisulfate, and nicotinamide or isonicotinamide in an organic solvent for preparing a mixture solution; a step of generating the clopidogrel co-crystal; and a step of collecting the clopidogrel co-crystal.
Abstract translation: 目的：提供含有氯吡格雷硫酸氢盐和烟酰胺的氯吡格雷共晶，以提高对热，光或水分的稳定性，并确保在水中的溶解度。 构成：氯吡格雷共晶体含有硫酸氢氯吡格雷，烟酰胺或异烟酰胺。 制备氯吡格雷共晶体的方法包括：将氯吡格雷硫酸氢盐和烟酰胺或异烟酰胺溶解在有机溶剂中以制备混合溶液的步骤; 产生氯吡格雷共晶的步骤; 以及收集氯吡格雷共晶体的步骤。
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公开(公告)号：KR101414183B1
公开(公告)日：2014-07-02
申请号：KR1020130009048
申请日：2013-01-28
Applicant: 한밭대학교 산학협력단
Abstract: The present invention relates to a bottle for unrefined rice wine having a gas discharging unit, which is sealed to package fermented wine such as unrefined rice wine, and primarily discharges only gas when a liquid is externally discharged due to a pressure rise caused by the generation of gas arising from fermentation or shaking when the bottle is opened, to prevent the liquid from overflowing. The bottle for unrefined rice wine having a gas discharging unit according to the present invention packages the fermented wine and installs a rotary bottle cap at an injection hole portion, wherein the gas discharging unit is formed at the injection hole of the bottle for unrefined rice wine to be separated from the injection hole of the bottle for unrefined rice wine after the gas is discharged and a liquid blocking mesh for passing only the gas is installed in the gas discharging unit.
Abstract translation: 本发明涉及一种具有气体放出单元的未精制米酒瓶，其被密封以包装诸如未精制米酒的发酵酒，并且当液体由于产生的压力升高而在外部排放时，仅主要排出气体 当瓶子打开时由发酵或摇晃产生的气体，以防止液体溢出。 根据本发明的具有排气单元的未精制米酒的瓶包装发酵酒，并在喷射孔部分安装旋转瓶盖，其中气体排出单元形成在用于未精制米酒的瓶的注入孔中 在气体排出之后与用于未精制米酒的瓶子的注入孔分离，并且仅在气体放出单元中安装用于通过气体的液体阻塞网。
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