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    변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법
    6.
    发明公开
    변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법 有权
    改良人肿瘤坏死因子受体-1多肽或片段及其制备方法

    公开(公告)号：KR1020110043485A

    公开(公告)日：2011-04-27

    申请号：KR1020100102075

    申请日：2010-10-19

    Applicant: 한올바이오파마주식회사

    Inventor： 김성욱 ,  전성수 ,  박승국 ,  김송영 ,  김은선 ,  정재갑 ,  김하나 ,  송연정

    IPC: C07K14/705 ,  C12N15/28 ,  C12N15/63 ,  A61P35/00

    CPC classification number: C07K14/70578

    Abstract: PURPOSE: A method for preparing modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof is provide enhance protease resistance and viability. CONSTITUTION: A modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof contains amino acid sequences which is modified at one or more sites selected from the group consisting of 61th, 68th, 78th, 85th, 106th, 107th, 109th, 121th, 128th, 133th, 135th, 136th, 138th, 141th, 150th, 156th, 161th, 200th, 203th, 206th and 207th amino acid sequence of natural type human tumor necrosis factor receptor 1.

    Abstract translation: 目的：制备修饰的人肿瘤坏死因子受体-1多肽或其片段的方法提供增强的蛋白酶抗性和活力。 构成：修饰的人肿瘤坏死因子受体-1多肽或其片段含有在选自第61,68,78,85,106,107,109,121,128的一个或多个位点修饰的氨基酸序列 天然型人肿瘤坏死因子受体1,133,133,133,131,141,151,156,161,202,203,206和207个氨基酸序列。

    변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법
    8.
    发明公开
    변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법 有权
    修饰的人肿瘤坏死因子受体-1聚合物或其片段及其制备方法

    公开(公告)号：KR1020120072323A

    公开(公告)日：2012-07-03

    申请号：KR1020110138751

    申请日：2011-12-21

    Applicant: 한올바이오파마주식회사

    Inventor： 김성욱 ,  전성수 ,  박승국 ,  김송영 ,  김은선 ,  정재갑 ,  김하나 ,  송연정

    IPC: C07K14/715 ,  C12N15/12 ,  A61K38/17 ,  A61P35/00

    CPC classification number: C07K14/7151 ,  A61K38/00 ,  C07K14/70575

    Abstract: PURPOSE: A modified human tumor necrosis factorreceptor-1(TNFR-1) polypeptide which binds to TNF in vivo or in vitro or a fragment thereof is provided to improve the binding force to TNF and protease resistance. CONSTITUTION: A modified human TNF-1 polypeptide or a fragment thereof contains: amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th, 161th, 200th, and 207th in wild type human TNFR-1 polypeptides of sequence number 1; amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th, 161th, 200th and 207th in wild type TNFRI171; amino acids having 5 modified amino acids including 92th, 95th, 97th, 98th amino acid residue and one amino acid residue selected from 68th and 161th, in wild type TNFRI126; or amino acids having 5 modified amino acids including 68th, 92th, 95th, 97th, and 98th amino acid residues in wild type TNFRI105.

    Abstract translation: 目的：提供在体内或体外与TNF结合的修饰的人肿瘤坏死因子受体-1（TNFR-1）多肽或其片段，以改善与TNF和蛋白酶抗性的结合力。 构成：修饰的人TNF-1多肽或其片段含有：具有5个经修饰的氨基酸的氨基酸，其包含第92,99,99个氨基酸残基和1个氨基酸残基，其选自第68，第161，第200和第207，在野生型 编号序列号1的人TNFR-1多肽; 在野生型TNFRI171中具有5个经修饰的氨基酸的氨基酸，包括第92,99,99个氨基酸残基和1个氨基酸残基，其选自第68,161,2200和207。 在野生型TNFRI126中具有5个经修饰的氨基酸的氨基酸，包括第92个，第95个，第97个，第98个氨基酸残基和一个选自第68和161个氨基酸残基; 或具有5个修饰氨基酸的氨基酸，包括野生型TNFRI105中的第68,92,95,97和98个氨基酸残基。

    변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
    10.
    发明公开
    변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 失效
    改性人类血小板聚糖片段及其制备方法

    公开(公告)号：KR1020100085879A

    公开(公告)日：2010-07-29

    申请号：KR1020100005348

    申请日：2010-01-20

    Applicant: 한올바이오파마주식회사

    Inventor： 김성욱 ,  전성수 ,  박승국 ,  정재갑 ,  이성률 ,  송연정 ,  심원조

    IPC: C07K14/505 ,  C12N15/12 ,  C12N15/63 ,  A61K38/17

    CPC classification number: C07K14/515 ,  A61K38/196 ,  Y02A50/473

    Abstract: PURPOSE: A mutated human thrombopoietin polypeptide fragment is provided to ensure platelet proliferation ability in vivo and in vitro and improved resistance to protease in vivo. CONSTITUTION: A human thrombopoietin polypeptide fragment contains mutated or substituted amino acid at 3rd, 6th, 8-12th, 14-18th, 20-23th, 25th, 26th, 31-34th, 39-41th, 43-46th, 48-52th, 55-57th, 56th, 60th, 62th, 64-67th, 69-79th, 81th, 86th, 89-91th, 93th, 95th, 97-104th, 107-109th, 112th, 116th, 117th, 120-123th, 126th, 128th, 129th, 131th, 133-147th, 150th, or 152th amino acid. A pharmaceutical formulation contains mutated TPO fragment having the mutated amino acid. A pharmaceutical composition for preventing or treating thrombocytopenia or diseases caused by thrombocytopenia contains the mutated TPO fragment.

    Abstract translation: 目的：提供突变的人血小板生成素多肽片段，以确保体内和体外的血小板增殖能力，并提高体内对蛋白酶的抗性。 构成：人血小板生成素多肽片段在第3,6,6,8,12,14,18,20-23,25,26,31-34,49-41,43-46,48-52，含有突变或取代的氨基酸， 第55-57号，第56号，第六十六次，第六十六次，第六十六次，第六十六次，第六次，第六次，第六次，第六次，第六十六次，第六十七次，第六十六次， 第128位，第129位，第131位，第133-147位，第150位或第152位氨基酸。 药物制剂含有具有突变的氨基酸的突变的TPO片段。 用于预防或治疗由血小板减少症引起的血小板减少症或疾病的药物组合物含有突变的TPO片段。

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