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公开(公告)号：US10695289B2
公开(公告)日：2020-06-30
申请号：US15766469
申请日：2016-10-07
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kenneth E. Brown , Daniel M. Dohmeier , Joan T. Moseman , Ying Zhang , Alan Harris , Gary Hattersley , Lisa A. Dick
Abstract: A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.
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公开(公告)号：US20220334108A1
公开(公告)日：2022-10-20
申请号：US17762945
申请日：2020-09-24
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Frederica Sgolastra , Stephen B. Roscoe , Daniel M. Dohmeier , Masayuki Nakamura , Catherine A. Bothof , Deniz Yuksel Yurt , David D. Johnson , Kyle A. Kalstabakken , Minghua Dai , Myungchan Kang , Neil Percy , Leslie M. Horton , Stephen M. Kennedy
IPC: G01N33/53 , G01N33/543 , G01N33/552 , G01N33/74 , C03C11/00 , C03C17/30
Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.
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