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    HEATING ELEMENT FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE
    1.
    发明申请
    HEATING ELEMENT FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE 审中-公开
    旋转多重荧光检测装置的加热元件

    公开(公告)号：WO2007005077A1

    公开(公告)日：2007-01-11

    申请号：PCT/US2006/010819

    申请日：2006-03-24

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： BEDINGHAM, William D., ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

    IPC: B01L7/00

    CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

    SYSTEMS AND METHODS FOR VALVING ON A SAMPLE PROCESSING DEVICE
    3.
    发明申请
    SYSTEMS AND METHODS FOR VALVING ON A SAMPLE PROCESSING DEVICE 审中-公开
    用于在样品处理装置上进行阀控的系统和方法

    公开(公告)号：WO2012158988A1

    公开(公告)日：2012-11-22

    申请号：PCT/US2012/038470

    申请日：2012-05-18

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： LUDOWISE, Peter D., ,  SMITH, Jeffrey D.,

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0688

    Abstract: A system and method for valving on a sample processing device. The system can include a valve chamber (134,234), a process chamber (150,250), and a valve septum (132,232) located between the valve chamber and the process chamber. The system can further include a fluid pathway (128,228) in fluid communication with an inlet of the valve chamber, wherein the fluid pathway is configured to inhibit a liquid from entering the valve chamber and collecting adjacent the valve septum when the valve septum is in a closed configuration. The method can include rotating the sample processing device to exert a first force on the liquid that is insufficient to move the liquid into the valve chamber; forming an opening in the valve septum; and rotating the sample processing device to exert a second force on the liquid to move the liquid into the valve chamber.

    Abstract translation: 一种用于在样品处理装置上进行阀门的系统和方法。 该系统可以包括位于阀室和处理室之间的阀室（134,234），处理室（150,250）和阀隔（132,232）。 该系统还可以包括与阀室的入口流体连通的流体通道（128,228），其中流体通道被配置为当阀隔膜处于阀室时阻止液体进入阀室并邻近阀隔膜收集 关闭配置。 该方法可以包括旋转样品处理装置以对液体施加不足以将液体移动到阀室中的第一力; 在隔膜中形成开口; 并且使样品处理装置旋转以对液体施加第二力以将液体移动到阀室中。

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