公开(公告)号：WO1997027274A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001441

申请日：1997-01-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, Bruce ,  MILLER, Robert, A. ,  BARNICKI, Scott, D. ,  SUMNER, Charles, Edwan, Jr.

IPC: C11C01/02

CPC classification number: C11C3/02 ,  C11C1/025 ,  C11C1/10 ,  C11C3/003

Abstract: This invention relates to a process for the isolation of fatty acids and fatty acid esters from complex naturally occurring mixtures which contain sterols, triglycerides and phospholipids. A preferred embodiment of the invention comprises (a) extracting lipids from egg yolk solids with methanol; (b) separating lipids including sterols from insoluble egg yolk components; (c) submitting the methanolic solution of lipids to alkaline hydrolysis and subsequent neutralization to convert lipids to free fatty acids together with sterols; (d) separating the said sterols and acids from an aqueous phase formed in the hydrolysis reaction; (e) heating said free fatty acids and sterols to convert the sterols to fatty acid sterol esters; (f) subjecting the mixture to distillation to separate the sterol esters from the free fatty acids; and (g) subjecting the said acids to esterification in the presence of glycerol to produce triglycerides of said fatty acids wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus. An enteral nutritional formula containing the triglycerides produced in the above process is also disclosed.

Abstract translation: 本发明涉及从含有甾醇，甘油三酯和磷脂的复杂天然存在的混合物中分离脂肪酸和脂肪酸酯的方法。 本发明的优选实施方案包括（a）用甲醇从蛋黄固体中提取脂质; （b）分离包括固醇的脂质不溶于蛋黄成分; （c）将脂质的甲醇溶液提取到碱性水解并随后中和，将脂质与甾醇一起转化为游离脂肪酸; （d）从所述水解反应中形成的水​​相中分离所述甾醇和酸; （e）加热所述游离脂肪酸和甾醇以将甾醇转化为脂肪酸甾醇酯; （f）使混合物进行蒸馏以将固醇酯与游离脂肪酸分离; 和（g）在甘油存在下使所述酸进行酯化以产生所述脂肪酸的甘油三酸酯，其中所得甘油三酸酯含有降低量的甾醇和磷。 还公开了含有在上述方法中生产的甘油三酯的肠内营养配方。

公开(公告)号：WO1997026804A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001138

申请日：1997-01-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, Bruce ,  MILLER, Robert, A. ,  BARNICKI, Scott, D. ,  SUMNER, Charles, Edwan, Jr. ,  PHILLIPS, James, C. ,  McCOMBS, Charles, A.

IPC: A23L01/30

CPC classification number: A23L33/17 ,  A23L33/12 ,  A23L33/40 ,  Y10S426/80 ,  Y10S426/801

Abstract: This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived form egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.

Abstract translation: 本发明涉及含有花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酸酯部分的甘油三酯在肠内营养或营养补充剂中的用途。 这些甘油三酯衍生自具有高水平的甾醇和磷的脂质混合物。 本发明的优选实施方案包括婴儿或肠内营养或营养补充剂，其包含衍生自卵黄的脂质源。 来自蛋黄的脂质源通过酯交换或水解制备，使混合物蒸馏，并用甘油进行酯化，得到含有所需的AA和DHA脂肪酸的甘油三酯，很少或没有固醇和磷。

公开(公告)号：EP0876110A1

公开(公告)日：1998-11-11

申请号：EP97903953.0

申请日：1997-01-24

Applicant: Abbott Laboratories

Inventor： MAZER, Terrence, Bruce ,  MILLER, Robert, A. ,  BARNICKI, Scott, D. ,  SUMNER, Charles, Edwan, Jr. ,  PHILLIPS, James, C. ,  McCOMBS, Charles, A.

IPC: A23L1 ,  A61K31 ,  A61P3 ,  C11C1 ,  C11C3

CPC classification number: A23L33/17 ,  A23L33/12 ,  A23L33/40 ,  Y10S426/80 ,  Y10S426/801

Abstract: This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived form egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.

Abstract translation: 本发明涉及包含花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酯部分的甘油三酯在肠内营养或营养补充剂中的用途。 这些甘油三酯衍生自具有高水平甾醇和磷的脂质混合物。 本发明的优选实施方案包括婴儿或肠营养或营养补充剂，其包含源自蛋黄的脂质源。 源自蛋黄的脂质源通过酯交换或水解制备，将混合物蒸馏并与甘油酯化以产生含有AA和DHA的所需脂肪酸以及少量或不含甾醇和磷的甘油三酯。