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公开(公告)号：WO2008014222A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/074159
申请日：2007-07-24
Applicant: ABBOTT LABORATORIES , VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
Inventor： VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
IPC: C07D498/18 , A61K31/395 , A61P37/06 , A61K31/4353
CPC classification number: C07D498/18
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
Abstract translation: 雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。 该晶体可以是水合物，脱水剂，溶剂化物或去溶剂化物。 雷帕霉素类似物可以具有式（I）的结构，其可任选地是前药，盐，衍生物或其组合：式（I）
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公开(公告)号：WO2010127190A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/033072
申请日：2010-04-30
Applicant: ABBOTT LABORATORIES , BORCHARDT, Thomas , BRACKEMYER, Paul , CATRON, Nathaniel , HENRY, Rodger , LOU, Xiaochun , RAVN, Matthew , ZHANG, Geoff , ZHOU, Deliang
Inventor： BORCHARDT, Thomas , BRACKEMYER, Paul , CATRON, Nathaniel , HENRY, Rodger , LOU, Xiaochun , RAVN, Matthew , ZHANG, Geoff , ZHOU, Deliang
IPC: C07D295/155 , A61K31/496 , A61P35/00
CPC classification number: C07D295/155
Abstract: ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
Abstract translation: ABT-263 bis-HCl及其结晶多晶型物是用于治疗特征在于过表达一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）的疾病的药物组合物的合适的活性药物成分。
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公开(公告)号：EP2051984A1
公开(公告)日：2009-04-29
申请号：EP07799771.6
申请日：2007-07-24
Applicant: ABBOTT LABORATORIES
Inventor： VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
IPC: C07D498/18 , A61K31/395 , A61P37/06 , A61K31/4353
CPC classification number: C07D498/18
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
Abstract translation: 雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。 晶体可以是水合物，脱水物，溶剂化物或去溶剂化物。 雷帕霉素类似物可具有式（I）的结构，其任选为前药，盐，衍生物或其组合：式（I）
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公开(公告)号：EP2424849A1
公开(公告)日：2012-03-07
申请号：EP10717392.4
申请日：2010-04-30
Applicant: Abbott Laboratories
Inventor： BORCHARDT, Thomas , BRACKEMYER, Paul , CATRON, Nathaniel , HENRY, Rodger , LOU, Xiaochun , RAVN, Matthew , ZHANG, Geoff , ZHOU, Deliang
IPC: C07D295/155 , A61K31/496 , A61P35/00
CPC classification number: C07D295/155
Abstract: ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
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