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公开(公告)号：WO2008127271A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/019660
申请日：2007-09-07
Applicant: ABBOTT LABORATORIES , WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
Inventor： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
IPC: C07K14/00 , C07K16/00 , C07H21/00 , C12N1/00 , C12N1/21 , C12N5/00 , C12N5/04 , C12N1/15 , C12N5/06 , C12N1/16 , C12P21/00
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.
Abstract translation: 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hTL-13活性有害的病症的人类受试者中。
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Patent Agency Ranking
公开(公告)号：EP1027362A1
公开(公告)日：2000-08-16
申请号：EP98956338.2
申请日：1998-10-29
Applicant: Abbott Laboratories
Inventor： PHAN, LY, Tam , OR, Yat, Sun , CHU, Daniel, T. , PLATTNER, Jacob, J. , CHEN, Yan , CLARK, Richard, F.
Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.
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公开(公告)号：EP1181300A1
公开(公告)日：2002-02-27
申请号：EP00936424.1
申请日：2000-05-31
Applicant: ABBOTT LABORATORIES
Inventor： PHAN, Ly T. , OR, Yat Sun , MA, Zhenkun , CHEN, Yan
IPC: C07H17/08 , A61K31/7048 , A61P31/04
CPC classification number: C07H17/08
Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infections in a mammal.
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公开(公告)号：EP2064336A2
公开(公告)日：2009-06-03
申请号：EP07873427.4
申请日：2007-09-07
Applicant: ABBOTT LABORATORIES
Inventor： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
Abstract translation: 本发明包括IL-13结合蛋白。 具体地，本发明涉及嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。
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公开(公告)号：EP1027362B1
公开(公告)日：2005-06-29
申请号：EP98956338.2
申请日：1998-10-29
Applicant: Abbott Laboratories
Inventor： PHAN, LY, Tam , OR, Yat, Sun , CHU, Daniel, T. , PLATTNER, Jacob, J. , CHEN, Yan , CLARK, Richard, F.
Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.
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公开(公告)号：EP1181300B1
公开(公告)日：2003-09-17
申请号：EP00936424.1
申请日：2000-05-31
Applicant: ABBOTT LABORATORIES
Inventor： PHAN, Ly T. , OR, Yat Sun , MA, Zhenkun , CHEN, Yan
IPC: C07H17/08 , A61K31/7048 , A61P31/04
CPC classification number: C07H17/08
Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infections in a mammal.
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