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1.发明申请HOMOGENEOUS MIXTURES OF LOW TEMPERATURE-MELTING DRUGS AND ADDITIVES FOR CONTROLLED RELEASE 审中-公开用于控制释放的低温熔融药物和添加剂的均质混合物
公开(公告)号：WO1996031197A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004513
申请日：1996-04-02
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , CHESKIN, Howard , HALE, Thomas, J. , VAN SCOIK, Kurt, G. , ZHOU, Ji
IPC: A61K09/48
CPC classification number: A61K9/4858 , A61K9/4866 , A61K31/19
Abstract: A controlled-release formulation comprising, in combination a therapeutically-effective dosage of drug which melts at low temperature and an additive selected from the group consisting of ethyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylamide, ethylene vinyl acetate copolymer, polymethylmethacrylate, polyhydroxyethyl methacrylate and waxes, and the like, such that the additive and the drug form a homogeneous drug-additive composite with a 92-to-97 % weight/weight of said drug, wherein said drug is selected from the group consisting of: sodium hydrogen divalproex, ibuprofen, ramipril, dibenzyline, erythrityl tetranitrate, isosorbide dinitrate, methosuximide, ketoprofen, gemfibrozil, paroxetine hydrochloride, and trimipramine maleate.
Abstract translation: 一种控释制剂，其组合包含治疗有效剂量的在低温下熔化的药物和选自乙基纤维素，甲基纤维素，羟丙基纤维素，聚丙烯酰胺，乙烯乙酸乙烯酯共聚物，聚甲基丙烯酸甲酯，甲基丙烯酸聚羟乙酯和 蜡等，使得添加剂和药物形成具有92-97％重量/重量的所述药物的均匀药物 - 添加剂复合物，其中所述药物选自：氢二氢硬脂酸钠， 布洛芬，雷米普利，二苯地平，四硝酸赤藓酸酯，硝酸异山梨酯，甲氧嘧啶，酮洛芬，吉非贝齐，盐酸帕罗西汀和马来酸丙咪嗪。
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2.发明公开HOMOGENEOUS MIXTURES OF LOW TEMPERATURE-MELTING DRUGS AND ADDITIVES FOR CONTROLLED RELEASE 失效延迟FOR主动输入低熔点药物和添加剂的均质混合气
公开(公告)号：EP0818990A1
公开(公告)日：1998-01-21
申请号：EP96910705.0
申请日：1996-04-02
Applicant: Abbott Laboratories
Inventor： CHESKIN, Howard , HALE, Thomas, J. , VAN SCOIK, Kurt, G. , ZHOU, Ji
CPC classification number: A61K9/4858 , A61K9/4866 , A61K31/19
Abstract: A controlled-release formulation comprising, in combination a therapeutically-effective dosage of drug which melts at low temperature and an additive selected from the group consisting of ethyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylamide, ethylene vinyl acetate copolymer, polymethylmethacrylate, polyhydroxyethyl methacrylate and waxes, and the like, such that the additive and the drug form a homogeneous drug-additive composite with a 92-to-97 % weight/weight of said drug, wherein said drug is selected from the group consisting of: sodium hydrogen divalproex, ibuprofen, ramipril, dibenzyline, erythrityl tetranitrate, isosorbide dinitrate, methosuximide, ketoprofen, gemfibrozil, paroxetine hydrochloride, and trimipramine maleate.
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