公开(公告)号：WO1998022488A1

公开(公告)日：1998-05-28

申请号：PCT/US1997020836

申请日：1997-11-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PREMCHANDRAN, Ramiya, H. ,  THOMAS, Albert, V. ,  BUSSE, Juliette, K. ,  DETE, John, E.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: A process for the preparation of N-demethyl-4"-deoxy-erythromycins A and B, having formula (I), wherein R is H or OH, by stepwise addition of iodine and base to the N-dimethyl-4"-deoxy-erythromycin, preferably, accompanied by sparging with an inert gas.

Abstract translation: 制备具有式（I）的N-脱甲基-4“ - 脱氧 - 红霉素A和B的方法，其中R a是H或OH，通过逐步加入碘和碱向N-二甲基-4 “脱氧红霉素，优选伴随着用惰性气体喷雾。