公开(公告)号：WO2008011499A1

公开(公告)日：2008-01-24

申请号：PCT/US2007/073850

申请日：2007-07-19

Applicant: ABBOTT LABORATORIES ,  MCDERMOTT, Todd, S. ,  WAGAW, Seble, H. ,  ENGSTROM, Kenneth, M. ,  GANDARILLA, Jorge ,  KRUGER, Albert ,  ROZEMA, Michael, J. ,  FICKES, Michael, G. ,  WITTENBERGER, Steven, J. ,  BHAGAVATULA, Lakshmi ,  BORCHARDT, Thomas, B.

Inventor： MCDERMOTT, Todd, S. ,  WAGAW, Seble, H. ,  ENGSTROM, Kenneth, M. ,  GANDARILLA, Jorge ,  KRUGER, Albert ,  ROZEMA, Michael, J. ,  FICKES, Michael, G. ,  WITTENBERGER, Steven, J. ,  BHAGAVATULA, Lakshmi ,  BORCHARDT, Thomas, B.

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D401/14 ,  C07D207/16 ,  C07D213/803 ,  C07D401/04 ,  C07F7/0803

Abstract: A process for making (2 S ,5 R )-5-ethynyl-1-{ N -(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.

Abstract translation: 制备（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈 及其盐，以及该方法中使用的中间体。

公开(公告)号：WO2003076431A1

公开(公告)日：2003-09-18

申请号：PCT/US2003/006406

申请日：2003-03-04

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  PATEL, Meena, V. ,  KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  ROHDE, Jeffrey ,  ENGSTROM, Kenneth, M.

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D403/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Abstract translation: 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。

公开(公告)号：EP2057145B1

公开(公告)日：2012-08-22

申请号：EP07799704.7

申请日：2007-07-19

Applicant: ABBOTT LABORATORIES

Inventor： MCDERMOTT, Todd, S. ,  WAGAW, Seble, H. ,  ENGSTROM, Kenneth, M. ,  GANDARILLA, Jorge ,  KRUGER, Albert ,  ROZEMA, Michael, J. ,  FICKES, Michael, G. ,  WITTENBERGER, Steven, J. ,  BHAGAVATULA, Lakshmi ,  BORCHARDT, Thomas, B.

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D401/14 ,  C07D207/16 ,  C07D213/803 ,  C07D401/04 ,  C07F7/0803

Abstract: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.

公开(公告)号：EP2057145A1

公开(公告)日：2009-05-13

申请号：EP07799704.7

申请日：2007-07-19

Applicant: ABBOTT LABORATORIES

Inventor： MCDERMOTT, Todd, S. ,  WAGAW, Seble, H. ,  ENGSTROM, Kenneth, M. ,  GANDARILLA, Jorge ,  KRUGER, Albert ,  ROZEMA, Michael, J. ,  FICKES, Michael, G. ,  WITTENBERGER, Steven, J. ,  BHAGAVATULA, Lakshmi ,  BORCHARDT, Thomas, B.

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D401/14 ,  C07D207/16 ,  C07D213/803 ,  C07D401/04 ,  C07F7/0803

Abstract: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.

公开(公告)号：EP1483258A1

公开(公告)日：2004-12-08

申请号：EP03716268.2

申请日：2003-03-04

Applicant: Abbott Laboratories

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  PATEL, Meena, V. ,  KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  ROHDE, Jeffrey ,  ENGSTROM, Kenneth, M.

IPC: C07D401/12 ,  C07D417/12 ,  C07D235/14 ,  C07D401/14 ,  C07D403/12 ,  A61K31/505

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D403/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.