公开(公告)号：WO1995004540A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008577

申请日：1994-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HAVIV, Fortuna ,  FITZPATRICK, Timothy, D. ,  SWENSON, Rolf, E. ,  NICHOLS, Charles, J. ,  MORT, Nicholas, A.

IPC: A61K37/00

CPC classification number: C07K7/23 ,  A61K38/00

Abstract: Decapeptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

Abstract translation: 在N-末端氮原子上被酰基取代的十肽是LHRH的有效拮抗剂，可用于抑制哺乳动物中的性激素水平。

公开(公告)号：WO1995004541A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008678

申请日：1994-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HAVIV, Fortuna ,  FITZPATRICK, Timothy, D. ,  SWENSON, Rolf, E. ,  NICHOLS, Charles, J. ,  MORT, Nicholas, A.

IPC: A61K37/00

CPC classification number: C07K7/23 ,  A61K38/00

Abstract: Decapeptide and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for hormones the levels of sex hormones in mammals.

Abstract translation: 通过包括呋喃-2-基，异烟酰基，烟酰基，2-，3-和4-喹啉羰基，莽草酰基，二氢嘧啶基和四氢呋喃-2-基的酰基在N-末端氮原子上取代的十肽和十一肽是有效的拮抗剂 的LHRH，可用于激素，哺乳动物性激素水平。