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1.发明申请
公开(公告)号：WO2005113536A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/014866
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES , ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D401/00
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）化合物其中R 1或R 2是三环或双环，其各自含有至少两个杂原子，R 1，R 2，R 3，R 3a，R 3b，R 4，R 5，L，X，X'，Y， Y'，Z和Z'如本文所定义，可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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2.发明申请
公开(公告)号：WO2009086163A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/087774
申请日：2008-12-19
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory, A. , MORTELL, Kathleen, H. , GOPALAKRISHNAN, Murali
Inventor： FAGHIH, Ramin , GFESSER, Gregory, A. , MORTELL, Kathleen, H. , GOPALAKRISHNAN, Murali
IPC: C07D277/02
CPC classification number: C07D277/18 , C07D401/02 , C07D417/02 , C07D417/14
Abstract: The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
Abstract translation: 本发明涉及作为神经元烟碱性受体的PAM的新型噻唑烷脲和酰胺衍生物，包含其的组合物，制备这些化合物的方法，以及使用这些化合物和组合物的方法。
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3.发明申请BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS 审中-公开具有循环取代的单环取代基的双环取代的氨基
公开(公告)号：WO2005113551A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/014863
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES , ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D417/14
CPC classification number: C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of formula (I) wherein R 1 or R 2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L 2 and L 3 , to a heteroaromatic core, and X, X', Y, Y', Z, Z', R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, L 2 , and L 3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）的化合物，其中R 1或R 2是通过由L 2和L 3表示的连接基直接连接或连接到杂芳族核心上的芳族或非芳族环，X，X'，Y，Y'，Z ，Z'，R1，R2，R3，R3a，R3b，R4，R5，L，L2和L3如本文所定义，可用于治疗组胺3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：WO2004043458A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035365
申请日：2003-11-05
Applicant: ABBOTT LABORATORIES
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-Jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-Yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , SHARMA, Padam, N. , BENNANI, Youssef, L. , CURTIS, Michael, P.
IPC: A61K31/40
CPC classification number: C07C255/58 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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5.发明申请NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS 审中-公开作为组胺-3受体配体的新型氨基酸及其治疗应用
公开(公告)号：WO2002074758A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/007107
申请日：2002-03-11
Applicant: ABBOTT LABORATORIES
Inventor： COWART, Marlon, D. , BENNANI, Youssef, L. , FAGHIH, Ramin , GFESSER, Gregory, A. , BLACK, Lawrence, A.
IPC: C07D307/79
CPC classification number: C07D307/79 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/81 , C07D333/54 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/04 , C07D491/08 , C07D491/10
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
Abstract translation: 式（I）化合物或其药学上可接受的盐，酯，酰胺或前药，其可用于调节哺乳动物中组胺3受体，并且其可用于治疗组胺3受体改善的疾病 配体。
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Patent Agency Ranking
公开(公告)号：EP1751130A2
公开(公告)日：2007-02-14
申请号：EP05763655.7
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D401/00
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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7.发明公开BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS 有权WITH环状取代的单环替代物双环的取代的胺
公开(公告)号：EP1751149A1
公开(公告)日：2007-02-14
申请号：EP05743943.2
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D417/14 , C07D401/04 , C07D417/04 , C07D413/04 , C07D409/14 , C07D413/14 , C07D215/12 , C07D401/14 , A61K31/4709 , A61P25/28 , A61P25/00
CPC classification number: C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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8.发明授权BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS 有权WITH环状取代的单环替代物双环的取代的胺
公开(公告)号：EP1751149B1
公开(公告)日：2012-06-06
申请号：EP05743943.2
申请日：2005-04-29
Applicant: Abbott Laboratories
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D401/08 , C07D417/14 , C07D401/04 , C07D417/04 , C07D413/04 , C07D409/14 , C07D215/12 , C07D401/14 , A61K31/4709 , A61P25/28 , A61P25/00 , C07D413/14
CPC classification number: C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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9.发明公开THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF 有权THIAZOLYLIDINHARNSTOFF-和酰胺衍生物和用于及其使用方法
公开(公告)号：EP2245020A2
公开(公告)日：2010-11-03
申请号：EP08866836.3
申请日：2008-12-19
Applicant: Abbott Laboratories
Inventor： FAGHIH, Ramin , GFESSER, Gregory, A. , MORTELL, Kathleen, H. , GOPALAKRISHNAN, Murali
IPC: C07D277/02 , C07D277/50 , A61P25/00
CPC classification number: C07D277/18 , C07D401/02 , C07D417/02 , C07D417/14
Abstract: The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
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10.发明公开NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS 审中-公开胺衍生物作为组胺-3受体配体和它们的治疗应用
公开(公告)号：EP1370546A2
公开(公告)日：2003-12-17
申请号：EP02715079.6
申请日：2002-03-11
Applicant: Abbott Laboratories
Inventor： COWART, Marlon, D. , BENNANI, Youssef, L. , FAGHIH, Ramin , GFESSER, Gregory, A. , BLACK, Lawrence, A.
IPC: C07D307/79 , C07D307/81 , C07D333/54 , C07D405/06 , C07D405/04 , C07D409/04 , C07D407/04 , C07D417/04 , A61K31/343 , A61K31/4427 , A61P9/00 , A61P11/06 , A61P25/00 , C07D413/04 , C07D409/10 , C07D521/00 , C07D491/10 , C07D491/08
CPC classification number: C07D307/79 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/81 , C07D333/54 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/04 , C07D491/08 , C07D491/10
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
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