公开(公告)号：WO1996040937A2

公开(公告)日：1996-12-19

申请号：PCT/US1996008097

申请日：1996-05-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  COWART, Marlon, D. ,  HALBERT, Donald, N. ,  KERWIN, James, F., Jr. ,  MCNALLY, Teresa

IPC: C12N15/54

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides an isolated and purified polynucleotide that encodes mammalian adenosine kinase, and to an isolated and purified adenosine kinase polypeptide. Human recombinant adenosine kinase and methods of using adenosine kinase polypeptides are also provided. Methods of making recombinant adenosine kinase using those polynucleotides and host cells transformed with those polynucleotides are also provided.

Abstract translation: 本发明提供了分离和纯化的多核苷酸，其编码哺乳动物腺苷激酶，以及分离和纯化的腺苷激酶多肽。 还提供了人重组腺苷激酶和使用腺苷激酶多肽的方法。 还提供了使用那些多核苷酸和用这些多核苷酸转化的宿主细胞制备重组腺苷激酶的方法。

公开(公告)号：WO2004080287A2

公开(公告)日：2004-09-23

申请号：PCT/US2004/007177

申请日：2004-03-10

Applicant: ABBOTT LABORATORIES

Inventor： FESIK, Stephen, W. ,  HALBERT, Donald, N. ,  METZGER, Randy, E. ,  MCDOWELL, Jeffrey, A. ,  SCHURDAK, Mark, E. ,  MORGAN-LAPPE, Susan, E. ,  SARTHY, Aparna, V.

IPC: A61B

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y207/01037 ,  C12Y207/04008 ,  C12Y207/11022

Abstract: A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia.

Abstract translation: 一种杀死癌细胞的方法，包括抑制选自CDK8，STK33，PRKCM，PRKACA，ACVR1B，CDK5R1，CDC42BPB，MPP6和CDC42BPA的基因的功能; 包含其抑制剂的药物组合物和检测细胞增生的方法。

公开(公告)号：EP0866867A2

公开(公告)日：1998-09-30

申请号：EP96917875.0

申请日：1996-05-31

Applicant: Abbott Laboratories

Inventor： COWART, Marlon, D. ,  HALBERT, Donald, N. ,  KERWIN, James, F., Jr. ,  MCNALLY, Teresa

IPC: C12N15 ,  C12N1 ,  C12N5 ,  C12N9 ,  A61K38 ,  C12R1

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides an isolated and purified polynucleotide that encodes mammalian adenosine kinase, and to an isolated and purified adenosine kinase polypeptide. Human recombinant adenosine kinase and methods of using adenosine kinase polypeptides are also provided. Methods of making recombinant adenosine kinase using those polynucleotides and host cells transformed with those polynucleotides are also provided.