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公开(公告)号：WO1998030574A1
公开(公告)日：1998-07-16
申请号：PCT/US1997005871
申请日：1997-04-07
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , OR, Yat, Sun , PHAN, Ly, Tam , CHU, Daniel, T. , SPINA, Kenneth, P. , HALLAS, Robert , ELLIOTT, Richard, L. , TUFANO, Michael
IPC: C07H17/00
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulas: (I); (II); (III); or (IV); wherein A, B, D and E, R , R , and Z specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.
Abstract translation: 化合物或其药学上可接受的盐和酯，其具有下式：（I）; （II）; （III）; 或（IV）; 其特征在于具有抗菌活性的A，B，D和E，R 1，R 2和Z，含有所述化合物的药物组合物，用这些组合物治疗细菌感染，以及制备化合物的方法 。
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公开(公告)号：WO1997017356A1
公开(公告)日：1997-05-15
申请号：PCT/US1996016585
申请日：1996-10-17
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , OR, Yat, Sun , PHAN, Ly, Tam , CHU, Daniel, T. , SPINA, Kenneth, P. , HALLAS, Robert , ELLIOTT, Richard, L.
IPC: C07H17/08
CPC classification number: C07H17/08
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.
Abstract translation: 式（I）的化合物或其药学上可接受的盐和酯; （II）; （III）或（IV）其中A，B，D和E，R 1，R 2和Z具体定义为具有抗菌活性，含有所述化合物的药物组合物，用这些组合物治疗抗菌感染，以及 制备化合物的方法。
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Patent Agency Ranking3.发明申请QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS 审中-公开喹诺酮类，喹诺酮类和吡虫啉类抗生素
公开(公告)号：WO1993016702A1
公开(公告)日：1993-09-02
申请号：PCT/US1993001766
申请日：1993-02-26
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , CHU, Daniel, T. , PLATTNER, Jacob, J. , HALLAS, Robert
IPC: A61K31/54
CPC classification number: C07D498/06 , C07D455/00 , C07D498/16 , C07D513/06 , Y02P20/55
Abstract: Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I) as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R is hydrogen or acarboxy-protecting group, R and R are substituents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.
Abstract translation: 公开了式（I）的喹苯并恶嗪，喹苯并噻嗪和吡啶并吖啶衍生物及其药学上可接受的盐，酯，酰胺和前药，其中R 1是氢或酰氧基保护基，R 2和R 3是取代基，A是氧，硫或碳，Z是卤素或含氮基团，X是氢，卤素或烷基，W是氢，烷基，氨基或卤素。 这些化合物具有有效的抗肿瘤活性。
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4.发明公开QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS 失效基于CHINOBENZOXAZINEN，CHINOBENZOTHIAZINEN和吡啶并吖啶抗肿瘤物质。
公开(公告)号：EP0608215A1
公开(公告)日：1994-08-03
申请号：EP91918185.0
申请日：1991-08-23
Applicant: ABBOTT LABORATORIES
Inventor： CHU, Daniel, T. , PLATTNER, Jacob, J. , HALLAS, Robert
CPC classification number: C07D455/00 , C07D513/06 , Y02P20/55
Abstract: L'invention se rapporte à de la quinobenzoxazine, des quinobenzothiazines et des dérivés de pyrido-acridine, représentés par la formule (I), ainsi qu'à leurs sels, esters, amides, et pro-médicaments pharmaceutiquement acceptables. Dans la formule (I), R1 représente hydrogène ou un groupe protecteur de carboxy, R2 et R3 représentent des substituants, A représente oxygène, soufre ou carbone, Z représente un halogène ou un groupe contenant de l'azote, X représente hydrogène, halogène ou alkyle, et W représente hydrogène, alkyle, amino ou halogène. Ces composés ont un pouvoir antinéoplastique puissant.
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公开(公告)号：EP0876388B1
公开(公告)日：2004-02-18
申请号：EP96936579.0
申请日：1996-10-17
Applicant: Abbott Laboratories
Inventor： OR, Yat, Sun , PHAN, Ly, Tam , CHU, Daniel, T. , SPINA, Kenneth, P. , HALLAS, Robert , ELLIOTT, Richard, L.
CPC classification number: C07H17/08
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公开(公告)号：EP0961776A1
公开(公告)日：1999-12-08
申请号：EP97920261.0
申请日：1997-04-07
Applicant: Abbott Laboratories
Inventor： OR, Yat, Sun , PHAN, Ly, Tam , CHU, Daniel, T. , SPINA, Kenneth, P. , HALLAS, Robert , ELLIOTT, Richard, L. , TUFANO, Michael
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulas: (I); (II); (III); or (IV); wherein A, B, D and E, R1, R2, and Z specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.
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公开(公告)号：EP0876388A1
公开(公告)日：1998-11-11
申请号：EP96936579.0
申请日：1996-10-17
Applicant: Abbott Laboratories
Inventor： OR, Yat, Sun , PHAN, Ly, Tam , CHU, Daniel, T. , SPINA, Kenneth, P. , HALLAS, Robert , ELLIOTT, Richard, L.
CPC classification number: C07H17/08
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R1, R2 and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.
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