公开(公告)号：WO1996017647A1

公开(公告)日：1996-06-13

申请号：PCT/US1995014887

申请日：1995-11-15

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CHOUDHURY, Hrishikesh ,  HELGREN, R., Hayes ,  VALENTINCIC, Charles, C.

IPC: A61M39/04

CPC classification number: A61M39/045 ,  Y10S604/905

Abstract: A valve including a substantially ridig cannula and a valve member positioned for operable communication with the cannula. The valve member is formed from a substantially resilient material, having a slit extending therethrough, and movable with respect to the cannula between a first closed position and a second open position. The slit is substantially closed by the resiliency of the material of the valve member when the valve member is positioned in the first closed position and the cannula cooperates to extend through the slit during movement of the valve member from the first closed position to the second open position to establish a fluid flow path through the cannula and the valve member. A sealing member is also provided independant from a flow of fluid within the fluid flow path to provide positive sealing of the slit when the valve member is positioned in the first closed position.

Abstract translation: 一种阀，包括一个基本上有齿的插管和一个定位成可与套管可操作连通的阀件。 阀构件由基本上弹性的材料形成，其具有穿过其延伸的狭缝，并且可相对于套管在第一关闭位置和第二打开位置之间移动。 当阀构件位于第一关闭位置时，狭缝基本上被阀构件的材料的弹性封闭，并且套管在阀构件从第一关闭位置运动到第二开口期间协同作用以延伸通过狭缝 以建立穿过套管和阀构件的流体流动路径。 当阀构件位于第一关闭位置时，也可以独立于流体流动路径内的流体流提供密封构件以提供狭缝的正密封。

公开(公告)号：WO1995017873A1

公开(公告)日：1995-07-06

申请号：PCT/US1994013438

申请日：1994-11-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FREDERICK, Waren, P. ,  HELGREN, R., Hayes ,  KRUGER, Robert, J. ,  LARKIN, Mark, E.

IPC: A61J01/00

CPC classification number: A61J1/1406 ,  A61J1/10 ,  A61J2205/20 ,  A61M39/045

Abstract: This invention pertains to a reseal member made of a soft elastomeric material used for sealing a fluid access port. The reseal member is inserted into the fluid access port and prevents fluids from passing therethrough. The reseal member is provided with a slit or recess, or both, that allows a user to exert minimal force to insert a blunt cannula into the reseal member to create a passage to pass fluids through the reseal member. Upon withdrawal of the blunt cannula, the reseal forms a generally fluid-tight seal so that fluids cannot pass through the reseal.

Abstract translation: 本发明涉及由用于密封流体通道的软弹性体材料制成的再密封构件。 重新密封构件插入到流体通道中并防止流体从中流过。 重新密封构件设置有狭缝或凹部或两者，其允许使用者施加最小的力以将钝头插管插入到再密封构件中，以产生通过流体通过重新密封构件的通道。 在拔出钝头套管后，再密封形成一个通常是流体密封的密封，使得流体不能通过重新密封。

公开(公告)号：WO1996003961A1

公开(公告)日：1996-02-15

申请号：PCT/US1995009074

申请日：1995-07-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HELGREN, R., Hayes ,  VALENTINCIC, Charles, C.

IPC: A61J01/00

CPC classification number: A61J1/1406 ,  B26D3/08 ,  B26D7/14 ,  B26F1/0084 ,  Y10T83/0252 ,  Y10T83/05 ,  Y10T83/0524 ,  Y10T83/323 ,  Y10T83/343 ,  Y10T83/9314

Abstract: A reseal (40) with a partially perforated membrane (108) is provided along with a method and apparatus for making such a reseal (40). In a preferred embodiment, the reseal membrane (108) is subjected to a tensile force, and a cutting edge of a lance (90) is advanced partially into the reseal membrane (108). More than one partial perforation can be provided in special configurations. Apparatus for providing a reseal membrane (108) with such a partial perforation includes a clamp assembly for clamping a periphery of the reseal, an anvil (80) for engaging one side of the reseal membrane (108), positioning mechanisms for effecting relative movement between the anvil (80) and clamp assembly to stretch the membrane (108), a lance (90) defining a cutting edge and a mounting structure for holding the lance adjacent the other side of the reseal (40), and a drive system for effecting relative movement between the lance (90) on the one hand and the anvil (80), clamping assembly, and reseal (40) on the other hand so as to effect partial penetration of the membrane (108) with the cutting edge of the lance (90).

Abstract translation: 提供具有部分穿孔的膜（108）的再密封（40）以及用于制造这种再密封（40）的方法和装置。 在一个优选实施例中，再密封膜（108）受到张力，并且喷枪（90）的切割边缘部分地进入再密封膜（108）。 可以在特殊配置中提供多于一个部分穿孔。 用于提供具有这种部分穿孔的再密封膜（108）的装置包括用于夹紧再密封周边的夹具组件，用于接合再密封膜（108）的一侧的砧座（80），用于实现重新密封膜 砧座（80）和用于拉伸膜（108）的夹具组件，限定切割边缘的喷枪（90）和用于保持喷枪邻近密封件（40）的另一侧的安装结构，以及用于实现 另一方面，一方面喷枪（90）与砧座（80），夹紧组件和再密封（40）之间的相对运动，以便使膜（108）与喷枪的切割刃部分地穿透 （90）。

公开(公告)号：WO1994022385A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003563

申请日：1994-03-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADOLF, Wayne, F. ,  HELGREN, R., Hayes ,  RENICK, James, T. ,  SZEMPRUCH, Walter, T.

IPC: A61B19/00

CPC classification number: A61J1/10 ,  A61B2050/314 ,  A61J1/05 ,  A61J1/1406 ,  A61M39/221 ,  A61M2207/00 ,  B29C59/007 ,  B29C65/02 ,  B29C65/08 ,  B29C65/18 ,  B29C65/48 ,  B29C66/001 ,  B29C66/0016 ,  B29C66/0018 ,  B29C66/112 ,  B29C66/131 ,  B29C66/24225 ,  B29C66/306 ,  B29C66/53247 ,  B29C66/7234 ,  B29L2031/7148 ,  Y10S383/906 ,  Y10S604/905 ,  B29C65/00

Abstract: The present invention relates to a sterile form, filled and sealed flexible solution container (10) and an attached port assembly (12) that allows for the sterile dispensing of the solution. In particular, the present invention relates to a sterile formed, filled and sealed flexible solution without interrupting the complete sealing of the hermetically sealed fluid container and which allows for the sterile packaging, storage and delivery of a sterile medical solution without heat degradation or oxygen permeation.

Abstract translation: 本发明涉及无菌形式，填充和密封的柔性溶液容器（10）和允许无菌分配溶液的附接端口组件（12）。 特别地，本发明涉及一种无菌的成形，填充和密封的柔性溶液，而不会中断密封的液体容器的完全密封，并且允许无菌包装，储存和递送无菌的药物溶液而不会发生热降解或氧气渗透 。

公开(公告)号：WO1992003202A2

公开(公告)日：1992-03-05

申请号：PCT/US1991005956

申请日：1991-08-20

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KRUGER, Robert, J. ,  FREDERICK, Warren, P. ,  HELGREN, R., Hayes ,  LARKIN, Mark, E. ,  MAYORAL, Joaquin ,  SCHMOLESKY, Brad, A. ,  SICZEK, Roman, W. ,  TIMMONS, Kenneth, J.

IPC: B01D0

CPC classification number: B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  A61M1/288 ,  A61M2205/3613 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24 ,  C02F1/441 ,  B01D2311/14 ,  B01D2311/165

Abstract: Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reverse osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. In one preferred embodiment, the first and second reverse osmosis assemblies are formed integrally in a side by side configuration. In an alternative embodiment, they are rolled about the core in an interleaf configuration. A method of forming a reverse osmosis device, a peritoneal dialysis treatment system and alternative treatment systems incorporating such a device as well as corresponding methods of treatment are also disclosed.

Abstract translation: 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于从源通过水的入口的壳体，用于使净化水从壳体通过的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二反渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 在一个优选实施例中，第一和第二反渗透组件以并排构造一体地形成。 在替代实施例中，它们以插页配置围绕核心滚动。 还公开了形成反渗透装置的方法，腹膜透析治疗系统以及包含这种装置的替代治疗系统以及相应的治疗方法。

公开(公告)号：EP0737058A1

公开(公告)日：1996-10-16

申请号：EP95902647.0

申请日：1994-11-18

Applicant: Abbott Laboratories

Inventor： FREDERICK, Waren, P. ,  HELGREN, R., Hayes ,  KRUGER, Robert, J. ,  LARKIN, Mark, E.

IPC: A61J1 ,  A61M39

CPC classification number: A61J1/1406 ,  A61J1/10 ,  A61J2205/20 ,  A61M39/045

Abstract: This invention pertains to a reseal member made of a soft elastomeric material used for sealing a fluid access port. The reseal member is inserted into the fluid access port and prevents fluids from passing therethrough. The reseal member is provided with a slit or recess, or both, that allows a user to exert minimal force to insert a blunt cannula into the reseal member to create a passage to pass fluids through the reseal member. Upon withdrawal of the blunt cannula, the reseal forms a generally fluid-tight seal so that fluids cannot pass through the reseal.

公开(公告)号：EP0796122A1

公开(公告)日：1997-09-24

申请号：EP95941405.0

申请日：1995-11-15

Applicant: Abbott Laboratories

Inventor： CHOUDHURY, Hrishikesh ,  HELGREN, R., Hayes ,  VALENTINCIC, Charles, C.

IPC: A61M39

CPC classification number: A61M39/045 ,  Y10S604/905

Abstract: A valve including a substantially ridig cannula and a valve member positioned for operable communication with the cannula. The valve member is formed from a substantially resilient material, having a slit extending therethrough, and movable with respect to the cannula between a first closed position and a second open position. The slit is substantially closed by the resiliency of the material of the valve member when the valve member is positioned in the first closed position and the cannula cooperates to extend through the slit during movement of the valve member from the first closed position to the second open position to establish a fluid flow path through the cannula and the valve member. A sealing member is also provided independant from a flow of fluid within the fluid flow path to provide positive sealing of the slit when the valve member is positioned in the first closed position.

公开(公告)号：EP0773776A1

公开(公告)日：1997-05-21

申请号：EP95927271.0

申请日：1995-07-19

Applicant: Abbott Laboratories

Inventor： HELGREN, R., Hayes ,  VALENTINCIC, Charles, C.

IPC: A61J1 ,  B26D3 ,  B26D7 ,  B26F1

CPC classification number: A61J1/1406 ,  B26D3/08 ,  B26D7/14 ,  B26F1/0084 ,  Y10T83/0252 ,  Y10T83/05 ,  Y10T83/0524 ,  Y10T83/323 ,  Y10T83/343 ,  Y10T83/9314

Abstract: A reseal (40) with a partially perforated membrane (108) is provided along with a method and apparatus for making such a reseal (40). In a preferred embodiment, the reseal membrane (108) is subjected to a tensile force, and a cutting edge of a lance (90) is advanced partially into the reseal membrane (108). More than one partial perforation can be provided in special configurations. Apparatus for providing a reseal membrane (108) with such a partial perforation includes a clamp assembly for clamping a periphery of the reseal, an anvil (80) for engaging one side of the reseal membrane (108), positioning mechanisms for effecting relative movement between the anvil (80) and clamp assembly to stretch the membrane (108), a lance (90) defining a cutting edge and a mounting structure for holding the lance adjacent the other side of the reseal (40), and a drive system for effecting relative movement between the lance (90) on the one hand and the anvil (80), clamping assembly, and reseal (40) on the other hand so as to effect partial penetration of the membrane (108) with the cutting edge of the lance (90).

公开(公告)号：EP0737058B1

公开(公告)日：1999-02-24

申请号：EP95902647.7

申请日：1994-11-18

Applicant: Abbott Laboratories

Inventor： FREDERICK, Waren, P. ,  HELGREN, R., Hayes ,  KRUGER, Robert, J. ,  LARKIN, Mark, E.

IPC: A61J1/00 ,  A61J1/05 ,  A61M39/04

CPC classification number: A61J1/1406 ,  A61J1/10 ,  A61J2205/20 ,  A61M39/045

Abstract: This invention pertains to a reseal member made of a soft elastomeric material used for sealing a fluid access port. The reseal member is inserted into the fluid access port and prevents fluids from passing therethrough. The reseal member is provided with a slit or recess, or both, that allows a user to exert minimal force to insert a blunt cannula into the reseal member to create a passage to pass fluids through the reseal member. Upon withdrawal of the blunt cannula, the reseal forms a generally fluid-tight seal so that fluids cannot pass through the reseal.

公开(公告)号：EP0544839A1

公开(公告)日：1993-06-09

申请号：EP91920741.0

申请日：1991-08-20

Applicant: ABBOTT LABORATORIES

Inventor： KRUGER, Robert, J. ,  FREDERICK, Warren, P. ,  HELGREN, R., Hayes ,  LARKIN, Mark, E. ,  MAYORAL, Joaquin ,  SCHMOLESKY, Brad, A. ,  SICZEK, Roman, W. ,  TIMMONS, Kenneth, J. 1988 Green Bay Road

IPC: A61M1 ,  B01D61 ,  B01D63 ,  C02F1

CPC classification number: B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  A61M1/288 ,  A61M2205/3613 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24 ,  C02F1/441 ,  B01D2311/14 ,  B01D2311/165

Abstract: Formulation et système de diffusion d'un produit médical qui comprend un dispositif d'osmose inversée servant à purifier l'eau provenant d'une source et comportant un boîtier pourvu d'une entrée pour la circulation de l'eau provenant de la source, une première sortie pour la circulation de l'eau purifiée provenant du boîtier et une deuxième sortie pour la circulation de l'eau usée restant après purification. Un premier ensemble multicouches d'osmose inversée est situé à l'intérieur du boîtier, en communication fluidique avec l'entrée, dans le but de purifier au moins une première partie de l'eau provenant de la source. On peut placer des substances chimiques de traitement d'eau dans un noyau autour duquel s'enroule le premier ensemble multicouches d'osmose inversée. Les substances chimiques de traitement sont en communication fluidique avec le premier ensemble multicouches d'osmose inversée pour recevoir la première partie d'eau purifiée et en supprimer au moins les contaminants chimiques. Un deuxième ensemble multicouches d'osmose inversée s'enroule également sur le noyau et se trouve en communication fluidique avec les substances chimiques de traitement d'eau pour recevoir l'eau purifiée chimiquement pour en purifier au moins une deuxième partie. Le deuxième ensemble multicouches d'osmose inversée est en communication fluidique avec la première sortie pour permettre la circulation de la deuxième partie d'eau purifiée à travers ladite sortie. Selon un mode de réalisation préféré, le premier et le deuxième ensembles d'osmose inversée sont solidaires en position contiguë. Selon un autre mode de réalisation, ils s'enroulent autour du noyau en position intercalée. L'invention décrit également un procédé de construction d'un dispositif d'osmose inversée, un système de dialyse péritonéale et des systèmes de traitement alternatifs intégrant ledit dispositif ainsi que des procédés de traitement correspondants.

Abstract translation: 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于从源通过水的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的芯中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 还公开了形成反渗透装置的方法，腹膜透析治疗系统和包含这种装置的替代治疗系统以及相应的治疗方法。