公开(公告)号：WO1997027486A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001074

申请日：1997-01-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HACKETT, John, R., Jr. ,  HOFF, Jane, A. ,  OSTROW, David, H. ,  GOLDEN, Alan, M.

IPC: G01N33/96

CPC classification number: G01N33/6857 ,  G01N33/6854 ,  G01N33/96

Abstract: The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.

Abstract translation: 本发明涉及特异性结合预定配体的试剂的使用，含有一个或多个抗体恒定区表位，并且具有特异性和亲和性。 试剂可以连续生产，用于制造用于定性或定量测量所需配体特异性抗体的诊断试剂盒（标准）和/或对照。 例如，本发明包括重组小鼠 - 人嵌合抗体，其可用作测定人抗体的测定和试剂盒中的校准物（标准品）和/或阳性对照。 可以使用任何物种来产生嵌合抗体，并且可以检测任何相应种类的抗体的存在。

公开(公告)号：EP1018019B1

公开(公告)日：2003-08-20

申请号：EP97903076.4

申请日：1997-01-17

Applicant: Abbott Laboratories

Inventor： HACKETT, John, R., Jr. ,  HOFF, Jane, A. ,  OSTROW, David, H. ,  GOLDEN, Alan, M.

IPC: G01N33/96 ,  G01N33/68

CPC classification number: G01N33/6857 ,  G01N33/6854 ,  G01N33/96

Abstract: The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.

公开(公告)号：EP1018019A1

公开(公告)日：2000-07-12

申请号：EP97903076.4

申请日：1997-01-17

Applicant: Abbott Laboratories

Inventor： HACKETT, John, R., Jr. ,  HOFF, Jane, A. ,  OSTROW, David, H. ,  GOLDEN, Alan, M.

IPC: G01N33/96 ,  G01N33/68

CPC classification number: G01N33/6857 ,  G01N33/6854 ,  G01N33/96

Abstract: The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.