公开(公告)号：WO1997037994A1

公开(公告)日：1997-10-16

申请号：PCT/US1997005122

申请日：1997-03-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MONTE, William, T. ,  JOHNSTON, Annette, A. ,  LINDBECK, Aline, C. ,  WANG, Xiu, C.

IPC: C07D487/22

CPC classification number: C07D487/22

Abstract: The present invention provides a process for the preparation of BPD 1,4-diene diester A-ring comprising reacting hematoporphyrin IX dimethyl ester with dimethyl acetylenedicarboxylate followed by purification of the product by a series of fractional crystallizations.

Abstract translation: 本发明提供了制备BPD 1,4-二烯二酯A环的方法，包括使卟啉Ⅸ二甲酯与乙炔二羧酸二甲酯反应，然后通过一系列分级结晶纯化产物。

公开(公告)号：EP0892803A1

公开(公告)日：1999-01-27

申请号：EP97917104.0

申请日：1997-03-31

Applicant: Abbott Laboratories

Inventor： MONTE, William, T. ,  JOHNSTON, Annette, A. ,  LINDBECK, Aline, C. ,  WANG, Xiu, C.

IPC: C07D487

CPC classification number: C07D487/22

Abstract: The present invention provides a process for the preparation of BPD 1,4-diene diester A-ring comprising reacting hematoporphyrin IX dimethyl ester with dimethyl acetylenedicarboxylate followed by purification of the product by a series of fractional crystallizations.