公开(公告)号：WO1997016174A1

公开(公告)日：1997-05-09

申请号：PCT/US1996016794

申请日：1996-10-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALEKI-GERHARDT, Azita ,  KESKE, Ernest, R.

IPC: A61K09/16

CPC classification number: A61K9/1635 ,  A61K9/1694 ,  A61K31/7048 ,  Y10S514/952 ,  Y10S514/974

Abstract: The prevent invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

Abstract translation: 本发明提供了大环内酯类抗生素水性造粒的方法，其包括将大环内酯类抗生素与卡波姆混合; 用水润湿混合物; 并混合混合物以形成大环内酯类抗生素卡波姆颗粒。

公开(公告)号：WO1993012767A1

公开(公告)日：1993-07-08

申请号：PCT/US1992009895

申请日：1992-11-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  VAN SCOIK, Kurt, G. ,  KESKE, Ernest, R. ,  CIPOLLO, Kent, L. ,  WEIS, Jeffery, K.

IPC: A61K09/14

CPC classification number: A61K9/2886 ,  A61K9/2077 ,  A61K9/2095 ,  Y10S514/891 ,  Y10S514/96

Abstract: A tablet is prepared from a powdered mixture by compacting the powder to remove air therefrom and causing physical granulation therein to yield a compact material containing granules. The granules are liberated from the compacted material and compressed into a tablet which is then provided with a coating. The starting powder mixture contains at least one material selected from amino acids, keto acids and polypeptides. The resultant tablet may be used in the treatment of chronic renal failure.

Abstract translation: 通过粉碎粉末从其中除去空气并在其中引起物理造粒以产生含有颗粒的致密材料，从粉末混合物制备片剂。 颗粒从压实的材料中释放并压制成片剂，然后提供涂层。 起始粉末混合物含有至少一种选自氨基酸，酮酸和多肽的材料。 所得片剂可用于治疗慢性肾功能衰竭。

公开(公告)号：EP0858324B1

公开(公告)日：2003-06-04

申请号：EP96937699.5

申请日：1996-10-18

Applicant: Abbott Laboratories

Inventor： SALEKI-GERHARDT, Azita ,  KESKE, Ernest, R.

IPC: A61K9/16

CPC classification number: A61K9/1635 ,  A61K9/1694 ,  A61K31/7048 ,  Y10S514/952 ,  Y10S514/974

Abstract: The prevent invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：EP0858324A1

公开(公告)日：1998-08-19

申请号：EP96937699.0

申请日：1996-10-18

Applicant: Abbott Laboratories

Inventor： SALEKI-GERHARDT, Azita ,  KESKE, Ernest, R.

IPC: A61K9 ,  A61K31 ,  A61K47

CPC classification number: A61K9/1635 ,  A61K9/1694 ,  A61K31/7048 ,  Y10S514/952 ,  Y10S514/974

Abstract: The prevent invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.