公开(公告)号：WO1993020446A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002920

申请日：1993-03-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PARSONS, Robert, G. ,  KOWAL, Robert ,  YUE, Vincent, T.

IPC: G01N33/573

CPC classification number: G01N33/53 ,  G01N33/54306 ,  G01N33/556 ,  G01N33/586 ,  Y10S435/807 ,  Y10S435/973 ,  Y10S436/816 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S436/901

Abstract: The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte immunoassay methods. Reagents, devices, and kits using the anti-hapten antibodies are also disclosed. The present invention also relates to dyed erythrocytes, preferably fixed, which are coated with antibodies. Also disclosed is the use of these dyed erythrocytes in agglutination assays to detect and measure the presence of an analyte in a sample. The analyte can be a hapten, an antigen, or an antibody. Also included are agglutination assays, compositions and kits using these dyed and coated erythrocytes.

公开(公告)号：WO1995015498A1

公开(公告)日：1995-06-08

申请号：PCT/US1994013390

申请日：1994-11-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PARSONS, Robert, G. ,  KOWAL, Robert

IPC: G01N33/543

CPC classification number: G01N33/53 ,  G01N33/54306 ,  G01N33/556 ,  G01N33/586 ,  Y10S436/807 ,  Y10S436/816 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S436/901

Abstract: The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte immunoassay methods. Reagents, devices, and kits using the anti-hapten antibodies are also disclosed. The present invention also relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of a dual antibody format. The present invention also relates to dyed erythrocytes, preferably fixed, which are coated with antibodies. Also disclosed is the use of these dyed erythrocytes in agglutination assays to detect and measure the presence of an analyte in a sample. The analyte can be a hapten, an antigen, or an antibody. Also included are agglutination assays, compositions and kits using these dyed and coated erythrocytes.

Abstract translation: 本发明涉及通过通用抗半抗原抗体检测和测量样品中分析物的量的免疫测定方法。 还公开了多分析物免疫测定方法。 还公开了使用抗半抗原抗体的试剂，装置和试剂盒。 本发明还涉及通过双抗体形式检测和测量样品中分析物的量的免疫测定方法。 本发明还涉及用抗体包被的染色的红细胞，优选固定的。 还公开了这些染色的红细胞在凝集测定中用于检测和测量样品中分析物的存在的用途。 分析物可以是半抗原，抗原或抗体。 还包括使用这些染色和包被的红细胞的凝集测定法，组合物和试剂盒。

公开(公告)号：EP0731917A1

公开(公告)日：1996-09-18

申请号：EP95902631.0

申请日：1994-11-18

Applicant: Abbott Laboratories

Inventor： PARSONS, Robert, G. ,  KOWAL, Robert

IPC: G01N33

CPC classification number: G01N33/53 ,  G01N33/54306 ,  G01N33/556 ,  G01N33/586 ,  Y10S436/807 ,  Y10S436/816 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S436/901

Abstract: The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte immunoassay methods. Reagents, devices, and kits using the anti-hapten antibodies are also disclosed. The present invention also relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of a dual antibody format. The present invention also relates to dyed erythrocytes, preferably fixed, which are coated with antibodies. Also disclosed is the use of these dyed erythrocytes in agglutination assays to detect and measure the presence of an analyte in a sample. The analyte can be a hapten, an antigen, or an antibody. Also included are agglutination assays, compositions and kits using these dyed and coated erythrocytes.

公开(公告)号：EP0634019A1

公开(公告)日：1995-01-18

申请号：EP93908643.0

申请日：1993-03-29

Applicant: ABBOTT LABORATORIES

Inventor： PARSONS, Robert, G. ,  KOWAL, Robert ,  YUE, Vincent, T.

IPC: G01N33

CPC classification number: G01N33/53 ,  G01N33/54306 ,  G01N33/556 ,  G01N33/586 ,  Y10S435/807 ,  Y10S435/973 ,  Y10S436/816 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S436/901

Abstract: The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte immunoassay methods. Reagents, devices, and kits using the anti-hapten antibodies are also disclosed. The present invention also relates to dyed erythrocytes, preferably fixed, which are coated with antibodies. Also disclosed is the use of these dyed erythrocytes in agglutination assays to detect and measure the presence of an analyte in a sample. The analyte can be a hapten, an antigen, or an antibody. Also included are agglutination assays, compositions and kits using these dyed and coated erythrocytes.

Abstract translation: 本发明涉及利用通用抗半抗原抗体来检测和测量样品中分析物的量的免疫测定方法。 还公开了多分析物免疫测定方法。 还公开了使用抗半抗原抗体的试剂，装置和试剂盒。 本发明还涉及用抗体包被的染色红细胞，优选固定的红细胞。 还公开了这些染色的红细胞在凝集测定中用于检测和测量样品中分析物的存在。 分析物可以是半抗原，抗原或抗体。 还包括使用这些染色和涂布的红细胞的凝集测定，组合物和试剂盒。