公开(公告)号：WO1995027475A1

公开(公告)日：1995-10-19

申请号：PCT/US1995003326

申请日：1995-03-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADJEI, Akwete, L. ,  LEE, Dennis, Y. ,  HLINAK, Anthony, J.

IPC: A61K09/00

CPC classification number: A61K9/008

Abstract: The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.

Abstract translation: 本发明提供了一种通过在气溶胶推进剂中研磨而含有固体的气溶胶药物制剂的连续研磨的方法和装置。

公开(公告)号：WO1996040089A2

公开(公告)日：1996-12-19

申请号：PCT/US1996009654

申请日：1996-06-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADJEI, Akwete, L. ,  GUPTA, Pramod, K. ,  LEE, Dennis, Y.

IPC: A61K09/72

CPC classification number: A61K9/008 ,  A61K47/44 ,  Y10S514/937

Abstract: Pharmaceutical compositions for aerosol delivery comprising (a) a medicament, (b) a non-chlorofluorocarbon propellant, and (c) a vegetable oil or a pharmaceutically acceptable derivative thereof, as well as a method for preparing such compositions in which unwanted aggregation of the medicament is prevented without the use of surfactants, protective colloids or cosolvents.

Abstract translation: 用于气雾剂输送的药物组合物，其包含（a）药物，（b）非氯氟烃推进剂和（c）植物油或其药学上可接受的衍生物，以及制备这样的组合物的方法， 在不使用表面活性剂，保护性胶体或助溶剂的情况下，可以防止药物。

公开(公告)号：WO2006135480A2

公开(公告)日：2006-12-21

申请号：PCT/US2006/013121

申请日：2006-04-07

Applicant: ABBOTT LABORATORIES ,  ZHU, Tong ,  JU, Tzuchi, R. ,  DAVILA, Claudia, M. ,  ENGH, Kevin, R. ,  GAO, Yi ,  GUSTAVSON, Linda, E. ,  JAYARAMAN, Shyamala, C. ,  LEBLOND, David ,  LEE, Dennis, Y.

Inventor： ZHU, Tong ,  JU, Tzuchi, R. ,  DAVILA, Claudia, M. ,  ENGH, Kevin, R. ,  GAO, Yi ,  GUSTAVSON, Linda, E. ,  JAYARAMAN, Shyamala, C. ,  LEBLOND, David ,  LEE, Dennis, Y.

IPC: A61K9/48 ,  A61K9/20 ,  A61K9/00 ,  A61K31/192 ,  A61K9/28 ,  A61K9/50

CPC classification number: A61K9/5026 ,  A61K9/0004 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/4808 ,  A61K31/192

Abstract: The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.

Abstract translation: 本发明涉及包含2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸中的至少一种的活性剂，2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸或缓冲的2- [4-（4-氯苯甲酰基）苯氧基] -2-甲基 - 丙酸。

公开(公告)号：EP0755245B1

公开(公告)日：2001-05-30

申请号：EP95914078.1

申请日：1995-03-14

Applicant: Abbott Laboratories

Inventor： ADJEI, Akwete, L. ,  LEE, Dennis, Y. ,  HLINAK, Anthony, J.

IPC: A61K9/00

CPC classification number: A61K9/008

Abstract: The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.

公开(公告)号：EP1868587A2

公开(公告)日：2007-12-26

申请号：EP06799902.9

申请日：2006-04-07

Applicant: Abbott Laboratories

Inventor： JU, Tzuchi, R. ,  DAVILA, Claudia, M. ,  ENGH, Kevin, R. ,  GAO, Yi ,  GUSTAVSON, Linda, E. ,  JAYARAMAN, Shyamala, C. ,  LEBLOND, David ,  LEE, Dennis, Y. ,  ZHU, Tong

IPC: A61K9/48 ,  A61K9/20 ,  A61K9/00 ,  A61K31/192 ,  A61K9/28 ,  A61K9/50

CPC classification number: A61K9/5026 ,  A61K9/0004 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/4808 ,  A61K31/192

Abstract: The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.

公开(公告)号：EP0755245A1

公开(公告)日：1997-01-29

申请号：EP95914078.0

申请日：1995-03-14

Applicant: Abbott Laboratories

Inventor： ADJEI, Akwete, L. ,  LEE, Dennis, Y. ,  HLINAK, Anthony, J.

IPC: A61J3 ,  A61K9 ,  B02B1 ,  B02B5

CPC classification number: A61K9/008

Abstract: The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.