公开(公告)号：WO1994026264A1

公开(公告)日：1994-11-24

申请号：PCT/US1994005341

申请日：1994-05-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DELLARIA, Joseph, F. ,  BASHA, Anwer ,  BLACK, Lawrence, A. ,  CHERNESKY, Linda, J. ,  LEE, Wendy

IPC: A61K31/335

CPC classification number: C07D405/12 ,  C07D309/12

Abstract: Compounds of structure (I), wherein W is selected from (a), and (b), where Q is oxygen or sulfur, R and R are hydrogen or alkyl, or R and R , together with the nitrogen atoms to which they are attached, define a radical of formula (II) or (III), R is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is -CH2-, oxygen, sulfur, or -NR where R is hydrogen or alkyl, L and L are selected from a valence bond, alkylene, propenylene, and propynylene, R , R , R , and R are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, -NR , where R is hydrogen or alkyl, and (c), where n = 0, 1, or 2, and R is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

Abstract translation: 其中W选自（a）和（b）中的结构（I）的化合物，其中Q是氧或硫，R 6和R 7是氢或烷基，或R 6和R 6， （II）或（III）的基团，其中R 8与它们所连接的氮原子一起定义为式（II）或（III）的基团，R 8选自氢，烷基，卤代烷基，任选取代的苯基，羟基烷基，氨基烷基，羧基烷基， （烷氧基羰基）烷基和（烷基氨基羰基）烷基; Z是-CH 2 - ，氧，硫或-NR 9，其中R 9是氢或烷基，L 1和L 2选自价键，亚烷基，亚丙烯基和亚丙炔基，R R 1，R 2，R 3和R 4独立地选自烷基，卤代烷基，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基，Y选自氧，-NR 10， 其中R 10是氢或烷基，和（c）其中n = 0,1或2，R 5是烷基，抑制白细胞三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。