公开(公告)号：EP1663183A2

公开(公告)日：2006-06-07

申请号：EP04816820.7

申请日：2004-08-23

Applicant: ABBOTT LABORATORIES

Inventor： ROSENBERG, Jöerg ,  REINHOLD, Ulrich ,  LIEPOLD, Bernd; ,  DERNDL, Gunther ,  BREITENBACH, Jörg ,  ALANI, Laman ,  GHOSH, Soumojeet

IPC: A61K31/00

CPC classification number: A61K31/425 ,  A61K9/146 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2866

Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.