公开(公告)号：WO1993014199A1

公开(公告)日：1993-07-22

申请号：PCT/US1993000146

申请日：1993-01-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MARCOTTE, Patrick, A.

IPC: C12N09/48

CPC classification number: C12N9/6462 ,  A61K38/00 ,  C12Y304/21073

Abstract: The present invention provides a method of making low molecular weight urokinase-type plasminogen activator comprising cleaving high molecular weight urokinase-type plasminogen activator with the metalloproteinase pump-1. Pharmaceutical compositions and methods of thrombolysis or preventing blood clot formation using that low molecular weight urokinase-type plasminogen activator are also provided.

Abstract translation: 本发明提供一种制备低分子量尿激酶型纤溶酶原激活物的方法，其包括用金属蛋白酶泵-1切割高分子量尿激酶型纤溶酶原激活物。 还提供了使用该低分子量尿激酶型纤溶酶原激活剂溶栓或预防血块形成的药物组合物和方法。