公开(公告)号：WO1992013892A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000687

申请日：1992-01-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GIBADLO, Mary, S. ,  TYNER, Joan, D. ,  MIMMS, Larry, T. ,  VALLARI, David, S.

IPC: C07K15/28

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

Abstract translation: 特异性结合推定的丙型肝炎病毒（HCV）包膜区的单克隆抗体。 还提供了分泌这些单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的方法和含有这些单克隆抗体的测定试剂盒。

公开(公告)号：WO1994004922A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007287

申请日：1993-08-03

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LENNARTZ, LIESELOTTE ,  MICHEL, Gerd ,  METHTA, Smriti, U. ,  TASKAR, Suhas ,  CLEMENS, John, M. ,  MIMMS, Larry, T. ,  CHAU, Kurt, H. ,  VALLARI, David, S.

IPC: G01N33/576

CPC classification number: G01N33/5767 ,  G01N2800/52

Abstract: A means for determining the effectiveness of interferon therapy in individuals who are infected with Hepatitis C Virus (HCV) and are receiving such therapy. Monitoring the level of anti-HCV IgM and/or anti-GOR IgG provide means for establishing whether or not the infected patient is responding to interferon therapy; such monitoring is especially useful for patients diagnosed with chronic acute HCV infections.

Abstract translation: 用于确定感染丙型肝炎病毒（HCV）并正在接受此类治疗的个体中干扰素治疗的有效性的方法。 监测抗HCV IgM和/或抗GOR IgG的水平提供了确定受感染的患者是否响应干扰素治疗的手段; 这种监测对于诊断为慢性急性HCV感染的患者特别有用。

公开(公告)号：WO1993020445A1

公开(公告)日：1993-10-14

申请号：PCT/US1992002523

申请日：1992-03-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  TASKAR, Suhas ,  CLEMENS, John, M. ,  MIMMS, Larry, T. ,  CHAU, Kurt, H. ,  VALLARI, David, S.

IPC: G01N33/563

CPC classification number: G01N33/5767 ,  G01N33/54393

Abstract: An assay for determining the presence of HCV IgM in a test sample. A test sample is contacted with at least one HCV antigen, incubated to form antigen/antibody complexes, and then contacted with an indicator reagent in order to produce a detectable signal. The amount of HCV IgM present in the test sample is proportional to the signal generated. The assay also can include the step of contacting the complexes with an enhancer compound prior to the use of an indicator reagent. Also provided is a test kit useful for performing the assay of the invention.

Abstract translation: 用于确定测试样品中HCV IgM存在的测定法。 将测试样品与至少一种HCV抗原接触，孵育形成抗原/抗体复合物，然后与指示剂试剂接触以产生可检测的信号。 测试样品中存在的HCV IgM的量与产生的信号成比例。 该测定还可以包括在使用指示剂试剂之前使复合物与增强剂化合物接触的步骤。 还提供了可用于进行本发明的测定的测试试剂盒。

公开(公告)号：WO1994026904A1

公开(公告)日：1994-11-24

申请号：PCT/US1994005090

申请日：1994-05-09

Applicant: ABBOTT LABORATORIES ,  UNIVERSITY OF GLASGOW

Inventor： ABBOTT LABORATORIES ,  UNIVERSITY OF GLASGOW ,  CARMAN, William ,  DECKER, Richard, H. ,  WALLACE, Lesley ,  MIMMS, Larry, T. ,  SOLOMON, Larry, R.

IPC: C12N15/51

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2730/10122 ,  Y10S435/975 ,  Y10S436/82

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

Abstract translation: 用于各种诊断和治疗应用的突变型乙型肝炎病毒（HBV）核酸序列，使用HBV核酸序列的试剂盒，HBV免疫原性颗粒和用于产生针对HBV的抗体的方法。 还提供了从HBV核酸序列产生抗体，多克隆或单克隆抗体的方法。

公开(公告)号：WO1992008738A1

公开(公告)日：1992-05-29

申请号：PCT/US1991008273

申请日：1991-11-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEHTA, Smriti, U. ,  JOHNSON-PAEPKE, Jill ,  GEORGE, Sheela, M. ,  DESAI, Suresh, M. ,  MIMMS, Larry, T. ,  DEVARE, Sushil, G. ,  TYNER, Joan, D. ,  GIBADLO, Mary, S.

IPC: C07K15/00

CPC classification number: C07K16/109

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

Abstract translation: 特异性结合丙型肝炎病毒C-100蛋白，丙型肝炎病毒33C蛋白和Hepatits C病毒CORE蛋白的单克隆抗体，以及产生这些单克隆抗体的杂交瘤。 还提供了使用这些单克隆抗体和含有这些抗体的测定试剂盒的方法。

公开(公告)号：EP0656116A1

公开(公告)日：1995-06-07

申请号：EP93919871.0

申请日：1993-08-03

Applicant: ABBOTT LABORATORIES

Inventor： LENNARTZ, LIESELOTTE ,  MICHEL, Gerd ,  METHTA, Smriti, U. ,  TASKAR, Suhas ,  CLEMENS, John, M. ,  MIMMS, Larry, T. ,  CHAU, Kurt, H. ,  VALLARI, David, S.

IPC: A61K39 ,  C12N15 ,  C12Q1 ,  G01N33

CPC classification number: G01N33/5767 ,  G01N2800/52

Abstract: A means for determining the effectiveness of interferon therapy in individuals who are infected with Hepatitis C Virus (HCV) and are receiving such therapy. Monitoring the level of anti-HCV IgM and/or anti-GOR IgG provide means for establishing whether or not the infected patient is responding to interferon therapy; such monitoring is especially useful for patients diagnosed with chronic acute HCV infections.

公开(公告)号：EP0556320A1

公开(公告)日：1993-08-25

申请号：EP92900907.0

申请日：1991-11-07

Applicant: ABBOTT LABORATORIES

Inventor： MEHTA, Smriti, U. ,  JOHNSON-PAEPKE, Jill ,  GEORGE, Sheela, M. ,  DESAI, Suresh, M. ,  MIMMS, Larry, T. ,  DEVARE, Sushil, G. ,  TYNER, Joan, D. ,  GIBADLO, Mary, S.

IPC: C12N5 ,  C07K16 ,  C12N15 ,  C12P21 ,  G01N33 ,  C12R1

CPC classification number: C07K16/109

Abstract: Anticorps monoclonaux se liant spécifiquement à la protéine C-100 du virus de l'hépatite C, à la protéine 33-C du virus de l'hépatite C ainsi qu'à la protéine core (noyau) du virus de l'hépatite C, et hybridomes produisant ces anticorps monoclonaux. L'invention concerne également des procédés d'utilisation de ces anticorps monoclonaux ainsi que des matériels de dosage contenant ces anticorps.

公开(公告)号：EP0569537A1

公开(公告)日：1993-11-18

申请号：EP92906219.0

申请日：1992-01-30

Applicant: ABBOTT LABORATORIES

Inventor： GIBADLO, Mary, S. ,  TYNER, Joan, D. ,  MIMMS, Larry, T. ,  VALLARI, David, S.

IPC: C12N5 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21 ,  G01N33 ,  A61K39 ,  C12R1

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

Abstract: L'invention se rapporte à des anticorps monoclonaux qui se lient spécifiquement aux régions d'enveloppe putatives du virus de l'hépatite C (VHC). L'invention décrit également des lignées cellulaires d'hybridomes qui sécrètent ces anticorps monoclonaux, des procédés d'utilisation de ces anticorps monoclonaux, et des kits d'analyse les contenant.

公开(公告)号：EP0556320B1

公开(公告)日：1999-03-24

申请号：EP92900907.4

申请日：1991-11-07

Applicant: ABBOTT LABORATORIES

Inventor： MEHTA, Smriti, U. ,  JOHNSON-PAEPKE, Jill ,  GEORGE, Sheela, M. ,  DESAI, Suresh, M. ,  MIMMS, Larry, T. ,  DEVARE, Sushil, G. ,  TYNER, Joan, D. ,  GIBADLO, Mary, S.

IPC: C12P21/08 ,  C12N5/20 ,  G01N33/53

CPC classification number: C07K16/109

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：EP0569537B1

公开(公告)日：1998-06-17

申请号：EP92906219.8

申请日：1992-01-30

Applicant: ABBOTT LABORATORIES

Inventor： GIBADLO, Mary, S. ,  TYNER, Joan, D. ,  MIMMS, Larry, T. ,  VALLARI, David, S.

IPC: C12P21/08 ,  C12N5/20 ,  G01N33/53

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.