公开(公告)号：EP1380842A3

公开(公告)日：2009-12-30

申请号：EP03021136.1

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC: G01N35/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A test sample container assembly for loading a plurality of test samples onto a test sample carousel of an automated analytical system and an automated, continuous and random access analytical system containing such test sample container assembly and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The test sample container assembly comprises (i) a housing with two parallel curved sides, said sides having the same radius of curvature as the test sample carousel, (ii) a top shelf with at least two openings for receiving test sample containers, (iii) a bottom parallel to and spaced apart from the top shelf defining with the curved surfaces therebetween a cavity, and (iv) wherein said bottom portion and said curved surfaces define a cavity therebetween wherein the at least two openings provide a predefined vertical alignment and the test sample container openings are presented in a plane parallel with the plane of the assembly shelf.

公开(公告)号：EP1450163A3

公开(公告)日：2004-09-15

申请号：EP04010902.7

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/02 ,  G01N35/10 ,  F04B53/00

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A bubble flushing aspirating and dispensing syringe having precision and volumetric accuracy, particularly for use in an automated, continuous and random access analytical system, is disclosed. The syringe comprises a piston (124) within a bore (128), the bore having seal means at a first end and a closed end (130) at a second end, wherein the piston forms an annulus (138) with the bore wall and seal means, and is capable of reciprocating therein. Fluid inlet (134) and fluid outlet (136) means are in communication with the annulus (138) and bore, the fluid inlet and fluid outlet means being located between the seal means and the bore closed end. A fluid source is in communication with the inlet means and a fluid conduit is in communication with the outlet means and an open-ended release tip. A drive means is connected to the piston for reciprocating the piston within the bore. As a result, fluid from the inlet, when connected to a fluid supply, flows through the annulus (138) around the sides of the piston and out through the fluid outlet to the open-ended tip, thereby creating a cross-flow pattern in the annulus (138) around the piston as it reciprocates in the bore to flush bubbles through the outlet.

公开(公告)号：EP1450162A2

公开(公告)日：2004-08-25

申请号：EP04010903.5

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/04

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A cartridge feeder apparatus for automated diagnostic systems is disclosed. The apparatus comprises a cartridge hopper means for receiving, storing and feeding cartridges (68) to a cartridge orientation mechanism, the cartridge orientation mechanism comprised of two opposed engageable orientation means (239) for engaging and disengaging a cartridge at each end of the cartridge. The cartridge has a funnel opening at a first end and a generally flat bottom at a second end.

Abstract translation: 公开了一种用于自动诊断系统的盒式馈送装置。 该装置包括用于将盒（68）接收，存储和馈送到盒取向机构的盒式存储器装置，盒取向机构包括两个相对的可接合定位装置（239），用于在盒的每一端处接合和分离盒。 墨盒在第一端具有漏斗开口，在第二端具有大致平坦的底部。

公开(公告)号：EP1028320A3

公开(公告)日：2001-03-14

申请号：EP00108051.4

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith B., Jane ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: The present invention relates to a method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples, comprising the following steps: introducing sample cups, reagent packs, and reaction vessels for performing said assays onto concentric carousels of a front end carousel, the reaction vessels being introduced to an outer carousel; identifying the reagent packs and sample cups; scheduling the assays; aligning the sample cups and reagent packs with a reaction vessel at a kitting station by rotating the respective carousels; kitting a unit dose disposable in a reaction vessel having multiple independent open chambers in accordance with the scheduled assay by transfer of the sample from the sample cup to a reaction vessel chamber and transfer of specific reagents to separate reaction vessel chambers from the reagent pack; transferring the kitted reaction vessel to a process carousel which is maintained under controlled environment conditions; pipetting the sample and various reagents into a reaction well of the reaction vessel, the amounts of reagent, sequencing of transfer and time spacing therebetween being predetermined by assay scheduling; incubating the pipetted sample and reagent mix; identifying and transferring the incubated mixture in the reaction well to one of at least two assay analytical stations; performing an analysis by reading the prepared reaction mixture and calibrating the reading; and recording the resulting assay reading analysis.

公开(公告)号：EP0831330A3

公开(公告)日：1998-08-12

申请号：EP97116256.5

申请日：1997-09-18

Applicant: Abbott Laboratories

Inventor： Arnquist, David C. ,  Barnes III,Grady ,  Dunn, Chadwick M. ,  East Jr.,Richard C. ,  Fritchie, Patrick P. ,  Gardner, Gregory E. ,  Grandone, Cass J. ,  Gray, Robert C. ,  Holen, James T. ,  McCoy, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian J. ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

Abstract: Embodiments described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. A physical length of the process lane is selectively varied.

公开(公告)号：EP1443329B1

公开(公告)日：2010-09-15

申请号：EP04010960.5

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith, Jane B. ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom, Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/02 ,  G01N33/53

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

公开(公告)号：EP1450162A9

公开(公告)日：2004-12-29

申请号：EP04010903.5

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/04 ,  B65G47/14 ,  B65G47/256

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A cartridge feeder apparatus for automated diagnostic systems is disclosed. The apparatus comprises a cartridge hopper means for receiving, storing and feeding cartridges (68) to a cartridge orientation mechanism, the cartridge orientation mechanism comprised of two opposed engageable orientation means (239) for engaging and disengaging a cartridge at each end of the cartridge. The cartridge has a funnel opening at a first end and a generally flat bottom at a second end.

公开(公告)号：EP1450162A8

公开(公告)日：2004-11-10

申请号：EP04010903.5

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/04 ,  B65G47/14 ,  B65G47/256

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A cartridge feeder apparatus for automated diagnostic systems is disclosed. The apparatus comprises a cartridge hopper means for receiving, storing and feeding cartridges (68) to a cartridge orientation mechanism, the cartridge orientation mechanism comprised of two opposed engageable orientation means (239) for engaging and disengaging a cartridge at each end of the cartridge. The cartridge has a funnel opening at a first end and a generally flat bottom at a second end.

公开(公告)号：EP1380844A2

公开(公告)日：2004-01-14

申请号：EP03021138.7

申请日：1993-03-24

Applicant: Abbott Laboratories

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC: G01N35/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A heater assembly for precision temperature and delivery control of liquids and an automated, continuous and random access analytical system containing such heater assembly and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The heater assembly comprises a body having internal resistance heating means and temperature control means, said body having a cavity suitable for accommodating liquid tubing means, said liquid tubing means in communication with liquid inlet and outlet means, wherein said cavity is suitable for housing a tubing means for maintaining liquids at a predetermined temperature, and wherein said liquid outlet means is suitable for forced or gravity release of the liquids and is mounted directly above analytical means for receiving liquids.

Abstract translation: 公开了一种用于液体的精确温度和输送控制的加热器组件和包含这种加热器组件并能够同时进行多个液体样品的多次测定的自动化，连续和随机存取分析系统。 加热器组件包括具有内部电阻加热装置和温度控制装置的主体，所述主体具有适于容纳液体管道装置的空腔，所述液体管道装置与液体入口和出口装置连通，其中所述腔体适于容纳管道 用于将液体保持在预定温度的装置，并且其中所述液体出口装置适于强制或重力地释放液体，并且直接安装在用于接收液体的分析装置上方。

公开(公告)号：EP0831329B1

公开(公告)日：2002-02-27

申请号：EP97114411.8

申请日：1997-08-20

Applicant: Abbott Laboratories

Inventor： Arnquist, David C. ,  Barnes, Grady, III ,  Button, Richard D. ,  Dunn, Chadwick M. ,  East, Richard C., Jr. ,  Fritchie, Patrick P. ,  Galitz, Charles M. ,  Grandone, Cass J. ,  Gardner, Gregory E. ,  Gray, Robert C. ,  Holen, James T. ,  Luoma, Robert P., II ,  McCory, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian John ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T. ,  Toth, Julius J.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467