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Patent Agency Ranking1.发明申请CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE 审中-公开作为SQUALENE SYNTHETASE和蛋白FARNESYLTRANSFERASE的抑制剂的CYCLOBUTANE衍生物
公开(公告)号：WO1995012572A1
公开(公告)日：1995-05-11
申请号：PCT/US1994012132
申请日：1994-10-20
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , BAKER, William, R. , ROCKWAY, Todd, W. , DONNER, B., Gregory , SHEN, Wang , ROSENBERG, Saul, H. , FAKHOURY, Stephen, A. , O'CONNOR, Stephen, J. , STOUT, David, M. , FUNG, Anthony, K., L. , GARVEY, David, S. , PRASAD, Rajnandan , SULLIVAN, Gerard, M.
IPC: C07C233/60
CPC classification number: C07C233/61 , C07C69/74 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C311/51 , C07C323/40 , C07C323/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D309/32 , C07D319/06 , C07D333/58
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
Abstract translation: 本发明提供式（I）化合物，除了可用于这些方法的中间体外，还可用于制备本发明化合物的方法，药物组合物和治疗由过量胆固醇或癌症引起的病症的方法或 真菌感染。
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2.发明申请CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE 审中-公开环肽衍生物及其作为蛋白质蛋白酶和平均合成酶的抑制剂
公开(公告)号：WO1995021815A1
公开(公告)日：1995-08-17
申请号：PCT/US1995001360
申请日：1995-02-01
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , STEIN, Herman, H. , BAKER, William, R. , FUNG, Anthony, K., L. , ROSENBERG, Saul, H. , ROCKWAY, Todd, W. , FAKHOURY, Stephen, A. , GARVEY, David, S. , DONNER, B., Gregory , McCLELLAN, William, J. , O'CONNOR, Stephen, J. , PRASAD, Rajnandan , SHEN, Wang , SULLIVAN, Gerard, M.
IPC: C07C233/60
CPC classification number: C07D295/135 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C323/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D211/70 , C07D217/06 , C07D277/34 , C07D307/52 , C07D307/58 , C07D307/91 , C07D317/64 , C07D333/20 , C07D333/32
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in theses processes, a pharmaceutical composition, and to methods of using such compounds.
Abstract translation: 本发明提供式（I）化合物或其药学上可接受的盐，其可用于抑制蛋白法呢基转移酶和癌基因蛋白Ras的法呢基化或抑制从头角鲨烯生产导致胆固醇生物合成的抑制， 除了可用于这些方法的中间体之外，还可以制备本发明的化合物，药物组合物以及使用这些化合物的方法。
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3.发明公开CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHETASE UND DER PROTEIN-FARNESYLTRANSFERASE。
公开(公告)号：EP0677039A1
公开(公告)日：1995-10-18
申请号：EP94931987.0
申请日：1994-10-20
Applicant: Abbott Laboratories
Inventor： BAKER, William, R. , ROCKWAY, Todd, W. , DONNER, B., Gregory , SHEN, Wang , ROSENBERG, Saul, H. , FAKHOURY, Stephen, A. , O'CONNOR, Stephen, J. , STOUT, David, M. , FUNG, Anthony, K., L. , GARVEY, David, S. , PRASAD, Rajnandan , SULLIVAN, Gerard, M.
IPC: C12N9 , A61K31 , A61P3 , A61P7 , A61P9 , A61P31 , A61P43 , C07C69 , C07C231 , C07C233 , C07C235 , C07C237 , C07C245 , C07C251 , C07C259 , C07C275 , C07C311 , C07C323 , C07C327 , C07D207 , C07D213 , C07D257 , C07D263 , C07D271 , C07D277 , C07D285 , C07D307 , C07D309 , C07D317 , C07D319 , C07D333
CPC classification number: C07C233/61 , C07C69/74 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C311/51 , C07C323/40 , C07C323/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D309/32 , C07D319/06 , C07D333/58
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
Abstract translation: 本发明提供式（I）化合物，除了可用于这些方法的中间体以外，还可用于制备本发明化合物的方法，药物组合物和治疗由过量胆固醇或癌症引起的病症的方法或 真菌感染。
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4.发明授权CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHETASE UND DER PROTEIN-FARNESYLTRANSFERASE
公开(公告)号：EP0677039B1
公开(公告)日：1999-03-10
申请号：EP94931987.5
申请日：1994-10-20
Applicant: Abbott Laboratories
Inventor： BAKER, William, R. , ROCKWAY, Todd, W. , DONNER, B., Gregory , SHEN, Wang , ROSENBERG, Saul, H. , FAKHOURY, Stephen, A. , O'CONNOR, Stephen, J. , STOUT, David, M. , FUNG, Anthony, K., L. , GARVEY, David, S. , PRASAD, Rajnandan , SULLIVAN, Gerard, M.
IPC: C07C233/60 , C07C323/40 , C07D257/04 , A61K31/16 , A61K31/41
CPC classification number: C07C233/61 , C07C69/74 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C311/51 , C07C323/40 , C07C323/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D309/32 , C07D319/06 , C07D333/58
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
Abstract translation: 本发明提供式（I）化合物，除了可用于这些方法的中间体以外，还可用于制备本发明化合物的方法，药物组合物和治疗由过量胆固醇或癌症引起的病症的方法或 真菌感染。
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5.发明公开TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS 失效三级和二级胺作为ALPHA-2拮抗剂和血清素录音抑制剂。
公开(公告)号：EP0646112A1
公开(公告)日：1995-04-05
申请号：EP93901313.0
申请日：1992-12-14
Applicant: ABBOTT LABORATORIES
Inventor： MEYER, Michael, D. , DeBERNARDIS, John, F. , PRASAD, Rajnandan , SIPPY, Kevin, B. , TIETJE, Karin, R.
IPC: C07D317 , A61K31 , A61P9 , A61P25 , A61P27 , A61P43 , C07C217 , C07D209 , C07D215 , C07D217 , C07D231 , C07D235 , C07D241 , C07D263 , C07D265 , C07D271 , C07D275 , C07D277 , C07D279 , C07D285 , C07D307 , C07D311 , C07D319 , C07D327 , C07D333 , C07D335 , C07D405 , C07D407 , C07D409 , C07D413 , C07D417
CPC classification number: C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
Abstract: The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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