公开(公告)号：WO1998002447A1

公开(公告)日：1998-01-22

申请号：PCT/US1997011064

申请日：1997-06-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HOCHLOWSKI, Jill, E. ,  JACKSON, Marianna ,  McALPINE, James, B. ,  RASMUSSEN, Ronald, R.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Antimicrobial compounds having formula (I) wherein R and R are independently selected from the group consisting of hydrogen and C1-to-C4 alkanoyl; R and R are selected from the group consisting of (a) R is hydrogen and R is hydroxy, (b) R is hydroxy and R is hydrogen, (c) R and R taken together are =0; or selected from the group consisting of hydrogen and hydroxy; and R and R are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R and R must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.

Abstract translation: 式（I）的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1 -C 4烷酰基; R 3和R 4选自（a）R 3是氢和R 4是羟基，（b）R 3是羟基，R 4是氢， （c）R 3和R 4一起为= 0; 或选自氢和羟基; R 5和R 6独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含这些化合物的药物组合物，通过其施用治疗细菌感染的方法和制备所述化合物的方法。

公开(公告)号：WO1993021770A1

公开(公告)日：1993-11-11

申请号：PCT/US1993003617

申请日：1993-04-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BRILL, Gregory, M. ,  BURRES, Neal, S. ,  CHEN, Randal, H. ,  HUMPHREY, Patrick, E. ,  McALPINE, James, B. ,  RASMUSSEN, Ronald, R.

IPC: A01N43/16

CPC classification number: C12R1/80 ,  C07C69/732 ,  C07D311/92 ,  C12P7/62 ,  C12P17/06

Abstract: Novel compounds having structural formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein one of R and R is hydrogen and the other is -CH=CHCOOH, X is >CH-, and Y is -O-; or, alternatively, the bond between X and Y is not present, X is -CH2-, and Y is -OH, as well as methods for their use, pharmaceutical compositions containing the same, and a process for their preparation via fermentation.

Abstract translation: 具有结构式（I）的新型化合物及其药学上可接受的盐和前药，其中R 1和R 2之一是氢，另一个是-CH = CHCOOH，X是> CH-，Y是-O - ; 或者，X和Y之间的键不存在，X是-CH 2 - ，Y是-OH，以及它们的使用方法，含有它们的药物组合物，以及通过发酵制备的方法。

公开(公告)号：WO1991007975A1

公开(公告)日：1991-06-13

申请号：PCT/US1990006929

申请日：1990-11-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DEVIDAS, Prem ,  RASMUSSEN, Ronald, R.

IPC: A61K31/745

CPC classification number: A01N43/90

Abstract: New trichothecene compositions are disclosed along with their use in methods of inhibiting nematode infection of plants.

公开(公告)号：EP0923594B1

公开(公告)日：2002-10-02

申请号：EP97931411.9

申请日：1997-06-24

Applicant: Abbott Laboratories

Inventor： HOCHLOWSKI, Jill, E. ,  JACKSON, Marianna ,  McALPINE, James, B. ,  RASMUSSEN, Ronald, R.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Antimicrobial compounds having formula (I) wherein R and R are independently selected from the group consisting of hydrogen and C1-to-C4 alkanoyl; R and R are selected from the group consisting of (a) R is hydrogen and R is hydroxy, (b) R is hydroxy and R is hydrogen, (c) R and R taken together are =0; or selected from the group consisting of hydrogen and hydroxy; and R and R are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R and R must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.

Abstract translation: 具有式（I）的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1 -C 4烷酰基; R 3和R 4选自（a）R 3为氢且R 4为羟基，（b）R 3为羟基且R 4为氢， （c）R 3和R 4一起为= 0; 或选自由氢和羟基组成的组; 并且R 5和R 6独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含此类化合物的药物组合物，通过其施用来治疗细菌感染的方法以及制备所述化合物的方法。

公开(公告)号：EP0923594A1

公开(公告)日：1999-06-23

申请号：EP97931411.0

申请日：1997-06-24

Applicant: Abbott Laboratories

Inventor： HOCHLOWSKI, Jill, E. ,  JACKSON, Marianna ,  McALPINE, James, B. ,  RASMUSSEN, Ronald, R.

IPC: C12P17 ,  A61K31 ,  A61P31 ,  C07H17 ,  C12R1

CPC classification number: C07H17/08

Abstract: Antimicrobial compounds having formula (I) wherein R?1 and R2¿ are independently selected from the group consisting of hydrogen and C¿1?-to-C4 alkanoyl; R?3 and R4¿ are selected from the group consisting of (a) R3 is hydrogen and R4 is hydroxy, (b) R3 is hydroxy and R4 is hydrogen, (c) R?3 and R4¿ taken together are =0; or selected from the group consisting of hydrogen and hydroxy; and R?5 and R6¿ are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R?5 and R6¿ must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.

Abstract translation: 具有式（I）的抗微生物化合物，其中R 1和R 2独立地选自氢和C 1〜C 4 - 链烷酰基; R 3和R 4选自（a）R 3是氢和R 4是羟基，（b）R 3是羟基和R 4是氢，（c）R 3和R 4'合起来是= 0; 或选自由氢和羟基组成的组; R 5和R 6'独立地选自氢，溴和氯，条件是R 5和R 6中的至少一个必须是溴。 还公开了包含此类化合物的药物组合物，通过其施用来治疗细菌感染的方法以及制备所述化合物的方法。