公开(公告)号：WO1996037495A1

公开(公告)日：1996-11-28

申请号：PCT/US1996006813

申请日：1996-05-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CHU, Daniel, T. ,  LI, Qun ,  RAYE, Kathleen

IPC: C07D491/16

CPC classification number: C07D491/16

Abstract: Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine compounds having formula (I), wherein A is sulfur or oxygen; R is selected from the group consisting of hydroxy, protected-hydroxy, C1-C6-alkoxy, halo, amino, C1-C6-alkylamino, hydroxy-C1-C6-alkylamino, bicyclic nitrogen-containing heterocycle, nitrogen-containing aromatic heterocycle, and nitrogen-containing heterocycle; R is selected from the group consisting of hydrogen, halo, C1-C6-alkyl, or halo-C1-C6-alkyl; R is selected from the group consisting of hydrogen, C1-C6-alkyl or C5-C7-cycloalkyl; and R and R are independently selected from the group consisting of hydrogen, C1-C6-alkyl or C1-C6-alkoxyl, having utility as intermediates or having antibacterial or antineoplastic activity.

Abstract translation: 苯并[5.6]吡喃并[2,3,4-ij]喹嗪和具有式（I）的苯并[5,6]噻喃并[2,3,4-ij]喹嗪化合物，其中A是硫或氧; R 1选自羟基，被保护的羟基，C 1 -C 6 - 烷氧基，卤素，氨基，C 1 -C 6烷基氨基，羟基-C 1 -C 6 - 烷基氨基，双环含氮杂环，含氮 芳族杂环和含氮杂环; R 2选自氢，卤素，C 1 -C 6 - 烷基或卤代-C 1 -C 6 - 烷基; R 3选自氢，C 1 -C 6 - 烷基或C 5 -C 7 - 环烷基; R 4和R 5独立地选自氢，C 1 -C 6烷基或C 1 -C 6烷氧基，其可用作中间体或具有抗细菌或抗肿瘤活性。