公开(公告)号：WO2003093288A1

公开(公告)日：2003-11-13

申请号：PCT/US2003/012970

申请日：2003-04-25

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Richard, F. ,  DJURIC, Stevan, M. ,  MA, Zhenkun ,  PHAN, Ly ,  RUPP, Michael, J.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 具有式（I）的改进的药代动力学特征的抗菌化合物及其前体药物的盐，前药和盐，用于制备该方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及用于预防和治疗细菌感染的方法 公开了这些化合物。

公开(公告)号：EP1027360A2

公开(公告)日：2000-08-16

申请号：EP98941119.4

申请日：1998-09-01

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  LI, Leping ,  RUPP, Michael, J. ,  CHU, Daniel, T.

IPC: C07H17/00

CPC classification number: C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula selected from the group consisting of (I), (II), (III), (IV) and (V), compositions comprising a therapeutically eff ective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically effective amount of a compound of formulas (I)-(V).

公开(公告)号：EP1161438B1

公开(公告)日：2004-05-06

申请号：EP00913805.8

申请日：2000-03-08

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat, Sun ,  CLARK, Richard, F. ,  MA, Zhenkun ,  RUPP, Michael, J.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：EP1161438A1

公开(公告)日：2001-12-12

申请号：EP00913805.8

申请日：2000-03-08

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat, Sun ,  CLARK, Richard, F. ,  MA, Zhenkun ,  RUPP, Michael, J.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：EP1501845A1

公开(公告)日：2005-02-02

申请号：EP03721887.2

申请日：2003-04-25

Applicant: Abbott Laboratories

Inventor： CLARK, Richard, F. ,  DJURIC, Stevan, M. ,  MA, Zhenkun ,  PHAN, Ly ,  RUPP, Michael, J.

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.