公开(公告)号：WO1992007088A1

公开(公告)日：1992-04-30

申请号：PCT/US1991007629

申请日：1991-10-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALDIVAR, Louis, Jr. ,  ENGLAND, Barbara, J.

IPC: C12Q01/54

CPC classification number: G01N33/96 ,  G01N33/72 ,  G01N2333/675 ,  G01N2496/80 ,  Y10S435/801 ,  Y10T436/146666

Abstract: A stabilized anoxic diagnostic reagent solution comprising an oxygen labile reagent, glucose oxidase, glucose, a hydrogen donor, sterile membrane fragments derived from bacteria having membranes containing an oxygen transfer system, and a reagent binding agent. The stabilized reagent has at least six months storage stability at 2-8 DEG C and open vial stability of at least three weeks.

Abstract translation: 一种稳定的缺氧诊断试剂溶液，其包含氧不稳定试剂，葡萄糖氧化酶，葡萄糖，氢供体，衍生自具有含氧转移系统的膜的细菌的无菌膜片段和试剂结合剂。 稳定的试剂在2-8℃具有至少六个月的储存稳定性，并且开瓶至少三周的稳定性。

公开(公告)号：WO1995017252A1

公开(公告)日：1995-06-29

申请号：PCT/US1994013559

申请日：1994-11-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALDIVAR, Louis, Jr. ,  RUTNARAK, Sangvorn

IPC: B01L03/00

CPC classification number: B01L3/502715 ,  B01L3/0275 ,  B01L2400/0406 ,  G01N15/12 ,  G01N15/1218

Abstract: Methods of using a disposable reagent pack (10) with an analytical instrument to analyze a blood sample are provided. According to one embodiment, a disposable reagent pack (10) comprising a sample well (120), a lysing solution well (28, 118), and a red blood cell analytic sample well (22, 112) is used. A blood sample is placed into the sample well (120) and the red blood cell analytic sample well (22, 112). Fluid is selectively transferred between the sample well (120) and the lysing solution well (118). Both the lysing solution well (28, 118) and the red blood cell analytic sample well (22, 112) are simultaneously presented to the analytical instrument for analysis.

Abstract translation: 提供了使用一次性试剂包（10）与分析仪器分析血液样品的方法。 根据一个实施例，使用包括样品阱（120），裂解溶液阱（28,118）和红细胞分析样品阱（22,112）的一次性试剂包（10）。 将血液样品放入样品孔（120）和红细胞分析样品（22,112）中。 流体在样品阱（120）和裂解溶液阱（118）之间选择性转移。 裂解溶液（28,118）和红细胞分析样品孔（22,112）均同时呈现给分析仪器进行分析。

公开(公告)号：EP0541729B1

公开(公告)日：1996-12-27

申请号：EP91919544.6

申请日：1991-10-18

Applicant: ABBOTT LABORATORIES

Inventor： SALDIVAR, Louis, Jr. ,  ENGLAND, Barbara, J.

IPC: C12Q1/54 ,  G01N33/00 ,  G01N33/96

CPC classification number: G01N33/96 ,  G01N33/72 ,  G01N2333/675 ,  G01N2496/80 ,  Y10S435/801 ,  Y10T436/146666

Abstract: A stabilized anoxic diagnostic reagent solution comprising an oxygen labile reagent, glucose oxidase, glucose, a hydrogen donor, sterile membrane fragments derived from bacteria having membranes containing an oxygen transfer system, and a reagent binding agent. The stabilized reagent has at least six months storage stability at 2-8 °C and open vial stability of at least three weeks.

公开(公告)号：EP0541729A1

公开(公告)日：1993-05-19

申请号：EP91919544.0

申请日：1991-10-18

Applicant: ABBOTT LABORATORIES

Inventor： SALDIVAR, Louis, Jr. ,  ENGLAND, Barbara, J.

IPC: G01N33

CPC classification number: G01N33/96 ,  G01N33/72 ,  G01N2333/675 ,  G01N2496/80 ,  Y10S435/801 ,  Y10T436/146666

Abstract: Réactif de diagnostic anoxique stabilisé en solution comprenant un réactif labile à l'oxygène, de l'oxydase de glucose, du glucose, un donneur d'hydrogène, des fragments de membranes stériles dérivés de bactéries ayant des membranes contenant un système de transfert d'oxygène, ainsi qu'un agent de liaison de réactif. Le réactif stabilisé peut être stocké de manière stable pendant au moins six mois entre 2 et 8 °C et il présente une stabilité d'au moins trois semaines dans une fiole ouverte.