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Patent Agency Ranking1.发明申请METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES 审中-公开制备纯化3-甲基-5-（1-烷基-2（S） - 吡咯烷酮）的方法ISOXAZOLES
公开(公告)号：WO1995007277A1
公开(公告)日：1995-03-16
申请号：PCT/US1994009734
申请日：1994-08-30
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , LIN, Nan-Horng , HE, Yun , ELLIOTT, Richard, L. , CHORGHADE, Mukund, S. , WITTENBERGER, Steven, J. , BUNNELLE, William, H. , NARAYANAN, Bikshandar, A. , SINGAM, Pulla, R. , ESCH, Thomas, K., J. , BEER, Dieter, O. , WITZIG, Christian, C. , HERZIG, Thomas, C. , RAO, Alla, V., Rama
IPC: C07D413/04
CPC classification number: C07D413/04
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
Abstract translation: 以高产率制备对映异构纯的3-甲基-5-（1-（C 1 -C 3 - 烷基）-2-吡咯烷基）异恶唑的新方法，其中将受保护的吡咯烷或2-氧代 - 吡咯烷起始原料与 合适的有机阴离子和所得的β-酮肟中间体被环化和脱水，以及可用于其制备的中间体。
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公开(公告)号：WO1998025917A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022791
申请日：1997-12-12
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , OLIVER-SHAFFER, Patricia, A. , NARAYANAN, Bikshandarkoil, A. , RESEK, James, E. , SINGAM, Pulla, R.
IPC: C07D317/60
CPC classification number: C07D405/04 , C07D317/60
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
Abstract translation: 本发明涉及产生具有增强的立体选择性的硝基酮非对映异构体的不对称迈克尔加成反应。
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3.发明授权
公开(公告)号：EP0946537B1
公开(公告)日：2005-05-04
申请号：EP97951641.6
申请日：1997-12-12
Applicant: Abbott Laboratories
Inventor： OLIVER-SHAFFER, Patricia, A. , NARAYANAN, Bikshandarkoil, A. , RESEK, James, E. , SINGAM, Pulla, R.
IPC: C07D317/60 , C07D405/04
CPC classification number: C07D405/04 , C07D317/60
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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4.发明公开PROCESS FOR REDUCTION OF (2R)-4-OXOAZETIDINONE-2-CARBOXYLIC ACID 审中-公开一种用于减少（2R）-4- OXOAZETIDINON -2-羧酸
公开(公告)号：EP1187809A1
公开(公告)日：2002-03-20
申请号：EP00939603.7
申请日：2000-06-06
Applicant: ABBOTT LABORATORIES
Inventor： RESEK, James, E. , PAREKH, Shyamal, I. , SINGAM, Pulla, R. , PATEL, Hermant, H. , CAIN, Michael, H. , NARAYANAN, Bikshandarkoil, A.
IPC: C07D205/04
CPC classification number: C07D205/04
Abstract: The present invention relates to a process for the reduction of an azetidinone-carboxylic acid to an azetidine-alcohol.
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5.发明公开
公开(公告)号：EP0946537A1
公开(公告)日：1999-10-06
申请号：EP97951641.0
申请日：1997-12-12
Applicant: Abbott Laboratories
Inventor： OLIVER-SHAFFER, Patricia, A. , NARAYANAN, Bikshandarkoil, A. , RESEK, James, E. , SINGAM, Pulla, R.
CPC classification number: C07D405/04 , C07D317/60
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
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