公开(公告)号：WO1998008095A1

公开(公告)日：1998-02-26

申请号：PCT/US1997013742

申请日：1997-08-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OSTROW, David, H. ,  COHEN, Larry, M. ,  EBLE, Kim, S. ,  MANEY, Peter, J. ,  STECKEL, Eric, W. ,  RUBIN, Brian, L. ,  WITTMAN, Craig, A. ,  JOHNSON, Paul, A.

IPC: G01N33/543

CPC classification number: G01N33/54313 ,  B01J19/2415 ,  B01J2219/00069 ,  B01J2219/00177

Abstract: A process for attaching a substance, especially an organic substance, onto one or more microparticles is provided. The process involves providing a quantity of a substance to be attached onto the microparticles, as well as a quantity of microparticles. The organic substance is then directed through a first conduit (12, 206) and the microparticles are sent through a second conduit (16, 212). The first (12, 206) and second (16, 212) conduits meet at a confluence point (26, 214, 305), and it is there that the substance and the microparticles mix such that the substance attaches to, and coats the microparticles. In a preferred embodiment, there is further provided mixing means such as an in-line static mixer (22, 216, 238, 307, 317, 323, 329) for mixing together the substance and the microparticles. The coated microparticles can be utilized in all manners of immunoassay, nucleic acid assay, cell assay and therapeutic injectable applications. The microparticles herein may also be replaced with another organic substance for conjugation or attachment to the first organic substance.

Abstract translation: 提供了将物质，特别是有机物质附着到一个或多个微粒上的方法。 该方法包括提供一定量的待附着到微粒上的物质以及一定量的微粒。 然后将有机物质引导通过第一导管（12,206），并将微粒通过第二导管（16,212）送出。 第一（12,206）和第二（16,212）管道在汇合点（26,214,305）处相遇，并且在那里物质和微粒混合，使得该物质附着并涂覆微粒 。 在优选实施例中，还提供了混合装置，例如用于将物质和微粒混合在一起的在线静态混合器（22,216,238,307,317,323,329）。 涂覆的微粒可以以免疫测定，核酸测定，细胞测定和治疗注射用途的所有方式使用。 本文中的微粒也可以用另一有机物质代替，以与第一有机物质共轭或附着。

公开(公告)号：EP0923737A1

公开(公告)日：1999-06-23

申请号：EP97937110.0

申请日：1997-08-05

Applicant: Abbott Laboratories

Inventor： OSTROW, David, H. ,  COHEN, Larry, M. ,  EBLE, Kim, S. ,  MANEY, Peter, J. ,  STECKEL, Eric, W. ,  RUBIN, Brian, L. ,  WITTMAN, Craig, A. ,  JOHNSON, Paul, A.

IPC: G01N33 ,  B01J19

CPC classification number: G01N33/54313 ,  B01J19/2415 ,  B01J2219/00069 ,  B01J2219/00177

Abstract: A process for attaching a substance, especially an organic substance, onto one or more microparticles is provided. The process involves providing a quantity of a substance to be attached onto the microparticles, as well as a quantity of microparticles. The organic substance is then directed through a first conduit (12, 206) and the microparticles are sent through a second conduit (16, 212). The first (12, 206) and second (16, 212) conduits meet at a confluence point (26, 214, 305), and it is there that the substance and the microparticles mix such that the substance attaches to, and coats the microparticles. In a preferred embodiment, there is further provided mixing means such as an in-line static mixer (22, 216, 238, 307, 317, 323, 329) for mixing together the substance and the microparticles. The coated microparticles can be utilized in all manners of immunoassay, nucleic acid assay, cell assay and therapeutic injectable applications. The microparticles herein may also be replaced with another organic substance for conjugation or attachment to the first organic substance.