公开(公告)号：WO1992013275A1

公开(公告)日：1992-08-06

申请号：PCT/US1992000604

申请日：1992-01-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GILBERT, Adrienne, L. ,  STEWART, James, L. ,  KIDD, Sarah, L. ,  DAWSON, George, J. ,  PYLE, Stephen, W.

IPC: G01N33/537

CPC classification number: G01N33/5306 ,  G01N33/5767

Abstract: An improved method for detecting antibodies is disclosed. The method involves the steps of a) mixing the specimen with a diluent comprising superoxide dismutase, and b) contacting the diluted specimen with at least one recombinant antigen expressed as a fusion protein with superoxide dismutase.

Abstract translation: 公开了一种用于检测抗体的改进方法。 该方法包括以下步骤：a）将样品与包含超氧化物歧化酶的稀释剂混合，以及b）将稀释的样品与表达为融合蛋白的至少一种重组抗原与超氧化物歧化酶接触。

公开(公告)号：WO2004070387A1

公开(公告)日：2004-08-19

申请号：PCT/US2004/003076

申请日：2004-02-03

Applicant: ABBOTT LABORATORIES

Inventor： SHAH, Dinesh, O. ,  CHENG, Yu ,  STEWART, James, L.

IPC: G01N33/576

CPC classification number: G01N33/5767

Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Such methods may be carried out in the presence of a diluent comprising a reductant or lacking a reductant. Furthermore, the performance of such methods may be maximized by altering such variables as the nature of the antigen coated on the solid phase, temperature application and time.

Abstract translation: 本发明涉及同时检测丙型肝炎病毒（HCV）抗原以及响应于HCV抗原产生的抗体的方法。 这种方法可以在包含还原剂或不含还原剂的稀释剂的存在下进行。 此外，通过改变诸如在固相上涂覆的抗原的性质，温度施用和时间等变量，可以使这些方法的性能最大化。

公开(公告)号：EP1590671A1

公开(公告)日：2005-11-02

申请号：EP04707764.9

申请日：2004-02-03

Applicant: ABBOTT LABORATORIES

Inventor： SHAH, Dinesh, O. ,  CHENG, Yu ,  STEWART, James, L.

IPC: G01N33/576

CPC classification number: G01N33/5767

Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Such methods may be carried out in the presence of a diluent comprising a reductant or lacking a reductant. Furthermore, the performance of such methods may be maximized by altering such variables as the nature of the antigen coated on the solid phase, temperature application and time.

公开(公告)号：EP0568639A1

公开(公告)日：1993-11-10

申请号：EP92905916.0

申请日：1992-01-24

Applicant: ABBOTT LABORATORIES

Inventor： GILBERT, Adrienne, L. ,  STEWART, James, L. ,  KIDD, Sarah, L. ,  DAWSON, George, J. ,  PYLE, Stephen, W.

IPC: C12Q1 ,  G01N33

CPC classification number: G01N33/5306 ,  G01N33/5767

Abstract: Procédé amélioré de détection d'anticorps. Le procédé comprend les étapes consistant a) à mélanger l'échantillon avec un diluant comprenant une superoxyde-dismutase, et b) à mettre en contact l'échantillon dilué avec au moins un antigène recombiné exprimé sous la forme d'une protéine de fusion avec la superoxyde-dismutase.