公开(公告)号：WO1993025672A1

公开(公告)日：1993-12-23

申请号：PCT/US1993005509

申请日：1993-06-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BAKER, Harold, Nordean ,  ENG, Katherine, Kit-Ming ,  GARNER, William, Darwin ,  MASSEI, Michael, Kyle ,  NECKLAWS, Elizabeth, Christine ,  OSIKOWICZ, Eugene, Walter ,  RAMP, Sally, Kay ,  TRACH, Paula

IPC: C12N09/96

CPC classification number: C07J41/0016 ,  G01N33/743 ,  Y10S435/962 ,  Y10S436/817 ,  Y10S436/825

Abstract: The present invention relates to the measurement of estradiol using competitive immunoassay methods. The inventors unexpectedly discovered that estrone and its derivatives conjugated to a label is a particularly effective tracer when used in conjunction with estradiol specific antibodies to determine estradiol levels in fluid samples. The present invention also utilizes 5 alpha -dihydrotestosterone to enhance the assay performance.

Abstract translation: 本发明涉及使用竞争性免疫测定方法测量雌二醇。 本发明人意外地发现，当与雌二醇特异性抗体结合使用以测定流体样品中的雌二醇水平时，与标记物缀合的雌酮及其衍生物是特别有效的示踪剂。 本发明还利用5α-二氢睾酮来提高测定性能。

公开(公告)号：EP0650521A1

公开(公告)日：1995-05-03

申请号：EP93914450.0

申请日：1993-06-09

Applicant: ABBOTT LABORATORIES

Inventor： BAKER, Harold, Nordean ,  ENG, Katherine, Kit-Ming ,  GARNER, William, Darwin ,  MASSEI, Michael, Kyle ,  NECKLAWS, Elizabeth, Christine ,  OSIKOWICZ, Eugene, Walter ,  RAMP, Sally, Kay ,  TRACH, Paula

IPC: G01N33 ,  C07J1 ,  C07J41 ,  C12N9

CPC classification number: C07J41/0016 ,  G01N33/743 ,  Y10S435/962 ,  Y10S436/817 ,  Y10S436/825

Abstract: The present invention relates to the measurement of estradiol using competitive immunoassay methods. The inventors unexpectedly discovered that estrone and its derivatives conjugated to a label is a particularly effective tracer when used in conjunction with estradiol specific antibodies to determine estradiol levels in fluid samples. The present invention also utilizes 5α-dihydrotestosterone to enhance the assay performance.

公开(公告)号：EP0650521B1

公开(公告)日：2001-03-07

申请号：EP93914450.7

申请日：1993-06-09

Applicant: ABBOTT LABORATORIES

Inventor： BAKER, Harold, Nordean ,  ENG, Katherine, Kit-Ming ,  GARNER, William, Darwin ,  MASSEI, Michael, Kyle ,  NECKLAWS, Elizabeth, Christine ,  OSIKOWICZ, Eugene, Walter ,  RAMP, Sally, Kay ,  TRACH, Paula

IPC: C12N9/96 ,  G01N33/536 ,  G01N33/545 ,  G01N33/548 ,  G01N33/74

CPC classification number: C07J41/0016 ,  G01N33/743 ,  Y10S435/962 ,  Y10S436/817 ,  Y10S436/825