公开(公告)号：WO2005100377A1

公开(公告)日：2005-10-27

申请号：PCT/US2005/014019

申请日：2005-04-06

Applicant: ABBOTT LABORATORIES ,  ZHAO, Chen ,  SUN, Minghua ,  COWART, Marlon, D. ,  BENNANI, Youssef, L.

Inventor： ZHAO, Chen ,  SUN, Minghua ,  COWART, Marlon, D. ,  BENNANI, Youssef, L.

IPC: C07J71/00

CPC classification number: C07J71/0042

Abstract: Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.

Abstract translation: 氮杂环绕组胺胺受体配体，包含这些化合物的药物组合物和使用这些化合物和组合物的方法在本文中描述。

公开(公告)号：WO1992017176A1

公开(公告)日：1992-10-15

申请号：PCT/US1992002120

申请日：1992-03-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SHAM, Hing, L. ,  KEMPF, Dale, J. ,  NORBECK, Daniel, W. ,  ZHAO, Chen

IPC: A61K31/44

CPC classification number: C07D213/30 ,  A61K38/00 ,  C07C33/46 ,  C07C43/164 ,  C07C43/1742 ,  C07C43/2055 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/315 ,  C07C45/004 ,  C07C45/29 ,  C07C45/567 ,  C07C45/59 ,  C07C45/62 ,  C07C45/673 ,  C07C45/74 ,  C07C53/134 ,  C07C69/34 ,  C07C69/65 ,  C07C69/732 ,  C07C211/27 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C217/48 ,  C07C229/08 ,  C07C229/26 ,  C07C229/34 ,  C07C233/36 ,  C07C233/40 ,  C07C235/10 ,  C07C235/12 ,  C07C235/34 ,  C07C235/78 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/10 ,  C07C239/18 ,  C07C239/20 ,  C07C247/10 ,  C07C251/40 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/16 ,  C07C275/24 ,  C07C311/03 ,  C07C311/13 ,  C07C311/18 ,  C07C317/10 ,  C07C317/28 ,  C07C317/44 ,  C07C323/12 ,  C07C323/25 ,  C07C381/00 ,  C07D207/08 ,  C07D207/24 ,  C07D209/42 ,  C07D211/62 ,  C07D213/40 ,  C07D213/42 ,  C07D213/56 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D215/16 ,  C07D217/16 ,  C07D217/26 ,  C07D231/12 ,  C07D233/56 ,  C07D233/84 ,  C07D239/38 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/36 ,  C07D277/42 ,  C07D277/56 ,  C07D295/088 ,  C07D295/15 ,  C07D295/155 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D303/04 ,  C07D303/22 ,  C07D303/36 ,  C07D303/48 ,  C07D417/12 ,  C07D487/04 ,  C07F9/3241 ,  C07F9/5333 ,  C07K5/021 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/06191 ,  C07C49/233 ,  C07C49/255 ,  C07C49/215 ,  C07C49/245 ,  C07C49/223 ,  C07C49/235

Abstract: Compounds are disclosed which are retroviral protease inhibitors. Also disclosed are methods of using the compounds and compositions for inhibiting a retroviral protease and for treating an HIV infection.

Abstract translation: 公开了作为逆转录病毒蛋白酶抑制剂的化合物。 还公开了使用化合物和组合物抑制逆转录病毒蛋白酶和治疗HIV感染的方法。

公开(公告)号：WO2008060767A3

公开(公告)日：2008-05-22

申请号：PCT/US2007/080133

申请日：2007-10-02

Applicant: ABBOTT LABORATORIES ,  ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

Inventor： ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

IPC: C07D491/04 ,  C07D493/04 ,  C07H17/04

Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

公开(公告)号：WO2008060766A2

公开(公告)日：2008-05-22

申请号：PCT/US2007/080132

申请日：2007-10-02

Applicant: ABBOTT LABORATORIES ,  COWART, Marlon D ,  ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D

Inventor： ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D

CPC classification number: A61K31/506 ,  A61K31/417 ,  A61K31/496 ,  A61K45/06

Abstract: This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.

Abstract translation: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。

公开(公告)号：WO2007100990A3

公开(公告)日：2007-09-07

申请号：PCT/US2007/062329

申请日：2007-02-16

Applicant: ABBOTT LABORATORIES ,  COWART, Marlon, D. ,  ZHAO, Chen ,  SUN, Minghua ,  BLACK, Lawrence, A. ,  ZHENG, Guo Zhu ,  GREGG, Robert, J. ,  ZHANG, Geoff, G.Z. ,  SHEIKH, Ahmad, Y. ,  LOU, Xiaochun ,  HENRY, Rodger, F. ,  BARNES, David, M. ,  KOLACZKOWSKI, Lawrence ,  HAIGHT, Anthony, R. ,  CHANG, Sou-Jen ,  WITTENBERGER, Steven, J. ,  FICKES, Michael, G.

Inventor： COWART, Marlon, D. ,  ZHAO, Chen ,  SUN, Minghua ,  BLACK, Lawrence, A. ,  ZHENG, Guo Zhu ,  GREGG, Robert, J. ,  ZHANG, Geoff, G.Z. ,  SHEIKH, Ahmad, Y. ,  LOU, Xiaochun ,  HENRY, Rodger, F. ,  BARNES, David, M. ,  KOLACZKOWSKI, Lawrence ,  HAIGHT, Anthony, R. ,  CHANG, Sou-Jen ,  WITTENBERGER, Steven, J. ,  FICKES, Michael, G.

IPC: C07D487/04 ,  A61K31/407

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives or a pharmaceutically acceptable salt, ester, amide, prodrug, or radiolabeled form thereof, wherein R 1 is alkyl, C 3 -C 5 cycloalkyl. or (C 3 -C 5 cycloalkyl)methyl; R 2a , R 2b , R 2c , R 2d , R 2e , and R 2f each are independently hydrogen, methyl, or fluoromethyl; R 3a , R 3b , R 3c , and R 3d each are independently hydrogen, alkyl, fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile, with the proviso that when one or more of R 3a , R 3b , R 3c , and R 3d are alkyl, then at least one of R 3a , R 3b , R 3c , and R 3d is fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile; L 1 is a bond, oxygen, sulfur, carbonyl, alkylene,. alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, NR 4 , -C(=O) NR 4 -, or -NR4C(=O)-; R 4 is hydrogen or alkyl; Cy 1 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; Z is a substituent R 6 or a group represented by -L 3 -Cy 3 ; R 6 is hydrogen, acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkyl, fiuoroalkoxy, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, alkylthio, amino, NHR 7 , NR 7 R 8 , -N(R 7 )C(=O)R 9 , -C(=O)NR 7 R 8 , or N(R 7 )SO 2 (R 10 ); L 3 is a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, NR 11 , -C(=O) NR 11 -, or -NR 11 C(=O)-;Cy 3 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; R 7 , R 8 , R 9 , R 10 , and R 11 at each occurrence are independently hydrogen,C 1-4 alkyl, C 3 -C 4 cycloalkyl, or a (C 3 -C 4 cycloalkyl)amine; are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：WO1995011224A1

公开(公告)日：1995-04-27

申请号：PCT/US1994010852

申请日：1994-09-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC: C07C225/16

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

Abstract translation: 公开了可用于制备基本上纯的式（3）化合物的中间体和方法，其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ），其中R a和R b独立地选自氢 ，低级烷基和苯基，Rc，Rd和Re独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; 和（ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7 a OC（O） - 其中R 7a为低级烷基或苄基; 或R 6和R 7与它们所键合的氮原子一起是（a）或（b），其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基，并且R 8是氢或 -C（O）R“其中R”是低级烷基，烷氧基，苄氧基或苯基，其中苯环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

公开(公告)号：WO1994014436A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012326

申请日：1993-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KEMPF, Dale, J. ,  NORBECK, Daniel, W. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  SOWIN, Thomas, J. ,  RENO, Daniel, S. ,  HAIGHT, Anthony, R. ,  COOPER, Arthur, J.

IPC: A61K31/425

CPC classification number: C07D413/12 ,  A61K31/425 ,  A61K31/427 ,  A61K31/70 ,  A61K38/00 ,  A61K45/06 ,  C07C33/46 ,  C07C43/164 ,  C07C43/1742 ,  C07C43/2055 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/315 ,  C07C45/004 ,  C07C45/29 ,  C07C45/567 ,  C07C45/62 ,  C07C45/673 ,  C07C45/74 ,  C07C53/134 ,  C07C69/34 ,  C07C69/65 ,  C07C69/732 ,  C07C211/27 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C229/08 ,  C07C229/26 ,  C07C229/34 ,  C07C233/36 ,  C07C233/40 ,  C07C235/10 ,  C07C235/12 ,  C07C235/34 ,  C07C235/78 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/10 ,  C07C239/18 ,  C07C239/20 ,  C07C247/10 ,  C07C251/40 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/16 ,  C07C275/24 ,  C07C311/03 ,  C07C311/13 ,  C07C311/18 ,  C07C317/10 ,  C07C317/28 ,  C07C317/44 ,  C07C323/12 ,  C07C323/25 ,  C07C381/00 ,  C07D213/26 ,  C07D213/30 ,  C07D213/34 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D235/14 ,  C07D235/16 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D277/56 ,  C07D295/13 ,  C07D295/205 ,  C07D295/215 ,  C07D303/36 ,  C07D307/42 ,  C07D333/16 ,  C07D401/12 ,  C07D417/12 ,  C07K5/06026 ,  C07K5/06078 ,  A61K31/00 ,  A61K2300/00 ,  C07C49/233 ,  C07C49/255 ,  C07C49/215 ,  C07C49/245 ,  C07C49/235 ,  C07C49/223

Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed.

Abstract translation: 公开了式（A）的逆转录病毒蛋白酶抑制化合物。

公开(公告)号：WO2009123967A1

公开(公告)日：2009-10-08

申请号：PCT/US2009/038775

申请日：2009-03-30

Applicant: ABBOTT LABORATORIES ,  LIU, Huaqing ,  DRIZIN, Irene ,  KOENIG, John, R. ,  COWART, Marlon, D. ,  ZHAO, Chen ,  WAKEFIELD, Brian, D. ,  BLACK, Lawrence, A. ,  ALTENBACH, Robert, J.

Inventor： LIU, Huaqing ,  DRIZIN, Irene ,  KOENIG, John, R. ,  COWART, Marlon, D. ,  ZHAO, Chen ,  WAKEFIELD, Brian, D. ,  BLACK, Lawrence, A. ,  ALTENBACH, Robert, J.

IPC: C07D239/84 ,  C07D403/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K31/517 ,  A61P11/06

CPC classification number: C07D401/04 ,  C07D239/70 ,  C07D239/84 ,  C07D239/88 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

Abstract translation: 本文描述了大环嘧啶化合物，包含这些化合物的组合物，制备化合物的方法，以及使用这些化合物和组合物治疗和预防疾病，病症和病症进展的方法。

公开(公告)号：WO2009085945A1

公开(公告)日：2009-07-09

申请号：PCT/US2008/087413

申请日：2008-12-18

Applicant: ABBOTT LABORATORIES ,  BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

Inventor： BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

IPC: A61K31/423 ,  A61K31/428 ,  C07D413/14 ,  C07D417/14 ,  A61P25/00 ,  A61P3/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。

公开(公告)号：WO2007038074A1

公开(公告)日：2007-04-05

申请号：PCT/US2006/036422

申请日：2006-09-19

Applicant: ABBOTT LABORATORIES ,  COWART, Marlon, D. ,  SUN, Minghua ,  ZHAO, Chen ,  ZHENG, Guo Zhu

Inventor： COWART, Marlon, D. ,  SUN, Minghua ,  ZHAO, Chen ,  ZHENG, Guo Zhu

IPC: C07D417/04 ,  C07D417/08 ,  C07D417/12 ,  C07D277/64 ,  C07D487/04 ,  A61K31/428 ,  A61K51/04 ,  A61P9/10

CPC classification number: C07D277/64 ,  C07D417/04 ,  C07D417/08 ,  C07D417/12 ,  C07D487/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。