公开(公告)号：WO2005012273A2

公开(公告)日：2005-02-10

申请号：PCT/US2004/024758

申请日：2004-07-30

Applicant: ABBOTT LABORATORIES ,  ROBBINS, Timothy, A. ,  ZHU, Helen ,  SHAO, Jun

Inventor： ROBBINS, Timothy, A. ,  ZHU, Helen ,  SHAO, Jun

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

Abstract translation: 本发明涉及制备取代噻唑的方法。 取代的噻唑，2-（4-羟基苯基）-4-甲基-1,3-噻唑-5-羧酸乙酯，也称为TEI-6720，可用于治疗痛风和高尿酸血症。 该化合物属于一类抑制黄嘌呤氧化酶并因此阻断尿酸生产的取代噻唑类。

公开(公告)号：EP1651624A2

公开(公告)日：2006-05-03

申请号：EP04779726.1

申请日：2004-07-30

Applicant: ABBOTT LABORATORIES

Inventor： ROBBINS, Timothy, A. ,  ZHU, Helen ,  SHAO, Jun

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.