公开(公告)号：CA2938547A1

公开(公告)日：2012-04-19

申请号：CA2938547

申请日：2011-10-12

Applicant: ABBVIE BAHAMAS LTD

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHEL V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  GAO YI ,  LIU DACHUN ,  PRATT JOHN K ,  ROCKWAY TODD W ,  MARING CLARENCE J ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBEL H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELIZZI MARY E ,  CARROLL WILLIAM A

IPC: C07D403/04 ,  A61K31/4184

Abstract: To provide compounds effective in inhibiting replication of Hepatitis C virus.SOLUTION: There are provided compounds having Formula I, or a pharmaceutically acceptable salt thereof, wherein X is Cto Ccarbocycle or 3- to 12-membered heterocycle; Land Lare bonds, Cto Calkylene, Cto Calkenylene or Cto Calkynylene; Lis bond or L-K-L, wherein K is bond, O, S or the like, Land Lare bonds, Cto Calkylene, Cto Calkenylene or Cto Calkynylene; A, B and D are Cto Ccarbocycle or 3- to 12-membered heterocycle; Y and Z are C(RR)N(R)-T-Ror the like, wherein R, R, Rand Rare H, halogen or the like, T is bond, Lor the like.SELECTED DRAWING: None